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Association of physical activity with development of uterine leiomyoma.

Abstract

The relation between physical activity and uterine leiomyomata (fibroids) has received little study, but exercise is protective for breast cancer, another hormonally mediated tumor. Participants in this study were randomly selected members of a health plan based in Washington, DC, aged 35-49 years (734 African Americans, 455 Whites) enrolled between 1996 and 1999. Fibroid status was based on ultrasound screening. Physical activity was based on detailed interview questions. Logistic regression with adjustment for body mass index and other risk factors showed that women in the highest category of physical activity were significantly less likely to have fibroids (odds ratio = 0.6, 95% confidence interval = 0.4, 0.9 for the highest vs. the lowest category (equivalent to approximately > or =7 hours/week vs <2 hours/week)). There was a dose-response pattern; a significant trend was seen for both African-American and White women. A multistate Bayesian analysis indicated that exercise was associated with tumor onset more strongly than with tumor growth. When data for women who reported major fibroid-related symptoms were excluded, results remained essentially unchanged, suggesting that the observed association could not be attributed to reverse causation (fibroids preventing exercise). The authors concluded that regular exercise might help women prevent fibroids.

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  • Authors+Show Affiliations

    ,

    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. baird@niehs.nih.gov

    , , ,

    Source

    American journal of epidemiology 165:2 2007 Jan 15 pg 157-63

    MeSH

    Adolescent
    Adult
    African Americans
    Body Mass Index
    District of Columbia
    European Continental Ancestry Group
    Female
    Humans
    Incidence
    Leiomyoma
    Middle Aged
    Motor Activity
    Prognosis
    Retrospective Studies
    Risk Factors
    Surveys and Questionnaires
    Ultrasonography
    Uterine Neoplasms

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    17090618

    Citation

    Baird, Donna Day, et al. "Association of Physical Activity With Development of Uterine Leiomyoma." American Journal of Epidemiology, vol. 165, no. 2, 2007, pp. 157-63.
    Baird DD, Dunson DB, Hill MC, et al. Association of physical activity with development of uterine leiomyoma. Am J Epidemiol. 2007;165(2):157-63.
    Baird, D. D., Dunson, D. B., Hill, M. C., Cousins, D., & Schectman, J. M. (2007). Association of physical activity with development of uterine leiomyoma. American Journal of Epidemiology, 165(2), pp. 157-63.
    Baird DD, et al. Association of Physical Activity With Development of Uterine Leiomyoma. Am J Epidemiol. 2007 Jan 15;165(2):157-63. PubMed PMID: 17090618.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association of physical activity with development of uterine leiomyoma. AU - Baird,Donna Day, AU - Dunson,David B, AU - Hill,Michael C, AU - Cousins,Deborah, AU - Schectman,Joel M, Y1 - 2006/11/07/ PY - 2006/11/9/pubmed PY - 2007/2/16/medline PY - 2006/11/9/entrez SP - 157 EP - 63 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 165 IS - 2 N2 - The relation between physical activity and uterine leiomyomata (fibroids) has received little study, but exercise is protective for breast cancer, another hormonally mediated tumor. Participants in this study were randomly selected members of a health plan based in Washington, DC, aged 35-49 years (734 African Americans, 455 Whites) enrolled between 1996 and 1999. Fibroid status was based on ultrasound screening. Physical activity was based on detailed interview questions. Logistic regression with adjustment for body mass index and other risk factors showed that women in the highest category of physical activity were significantly less likely to have fibroids (odds ratio = 0.6, 95% confidence interval = 0.4, 0.9 for the highest vs. the lowest category (equivalent to approximately > or =7 hours/week vs <2 hours/week)). There was a dose-response pattern; a significant trend was seen for both African-American and White women. A multistate Bayesian analysis indicated that exercise was associated with tumor onset more strongly than with tumor growth. When data for women who reported major fibroid-related symptoms were excluded, results remained essentially unchanged, suggesting that the observed association could not be attributed to reverse causation (fibroids preventing exercise). The authors concluded that regular exercise might help women prevent fibroids. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/17090618/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwj363 DB - PRIME DP - Unbound Medicine ER -