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Time trends of gastroesophageal reflux disease: a systematic review.
Clin Gastroenterol Hepatol 2007; 5(1):17-26CG

Abstract

There is a perception that the prevalence of gastroesophageal reflux disease (GERD) is increasing, but few studies have directly tackled this issue. By using a systematic approach, this review aimed to assess objectively whether the prevalence of GERD is changing with time. First, population-based studies that reported the prevalence of at least weekly heartburn and/or acid regurgitation were subjected to a time-trend analysis with a Poisson regression model. Second, population-based studies reporting the prevalence of GERD symptoms at 2 time points in the same source population were reviewed. Third, longitudinal studies that charted the prevalence of GERD symptoms and esophagitis in primary and secondary care were examined. The Poisson model revealed a significant (P < .0001) trend for an increase in the prevalence of reflux symptoms in the general population over time. Separately, significant increases with time were found for North America (P = .0005) and Europe (P < .0001) but not Asia (P = .49). Studies of the same source population over time indicated an increase in the prevalence of GERD in the U.S., Singapore, and China but not Sweden. An increase in the prevalence of GERD or esophagitis was found in the majority of longitudinal studies. There is evidence that the prevalence of GERD has increased during the past 2 decades. If this trend continues, it could contribute to the rapidly increasing incidence of more serious complications associated with GERD, such as esophageal adenocarcinoma, as well as costs to healthcare systems and employers.

Authors+Show Affiliations

Gastroenterology and Health Services Research Sections, Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA. hasheme@bcm.tmc.edu

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Systematic Review

Language

eng

PubMed ID

17142109

Citation

El-Serag, Hashem B.. "Time Trends of Gastroesophageal Reflux Disease: a Systematic Review." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 5, no. 1, 2007, pp. 17-26.
El-Serag HB. Time trends of gastroesophageal reflux disease: a systematic review. Clin Gastroenterol Hepatol. 2007;5(1):17-26.
El-Serag, H. B. (2007). Time trends of gastroesophageal reflux disease: a systematic review. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 5(1), pp. 17-26.
El-Serag HB. Time Trends of Gastroesophageal Reflux Disease: a Systematic Review. Clin Gastroenterol Hepatol. 2007;5(1):17-26. PubMed PMID: 17142109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Time trends of gastroesophageal reflux disease: a systematic review. A1 - El-Serag,Hashem B, Y1 - 2006/12/04/ PY - 2006/12/5/pubmed PY - 2007/4/4/medline PY - 2006/12/5/entrez SP - 17 EP - 26 JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin. Gastroenterol. Hepatol. VL - 5 IS - 1 N2 - There is a perception that the prevalence of gastroesophageal reflux disease (GERD) is increasing, but few studies have directly tackled this issue. By using a systematic approach, this review aimed to assess objectively whether the prevalence of GERD is changing with time. First, population-based studies that reported the prevalence of at least weekly heartburn and/or acid regurgitation were subjected to a time-trend analysis with a Poisson regression model. Second, population-based studies reporting the prevalence of GERD symptoms at 2 time points in the same source population were reviewed. Third, longitudinal studies that charted the prevalence of GERD symptoms and esophagitis in primary and secondary care were examined. The Poisson model revealed a significant (P < .0001) trend for an increase in the prevalence of reflux symptoms in the general population over time. Separately, significant increases with time were found for North America (P = .0005) and Europe (P < .0001) but not Asia (P = .49). Studies of the same source population over time indicated an increase in the prevalence of GERD in the U.S., Singapore, and China but not Sweden. An increase in the prevalence of GERD or esophagitis was found in the majority of longitudinal studies. There is evidence that the prevalence of GERD has increased during the past 2 decades. If this trend continues, it could contribute to the rapidly increasing incidence of more serious complications associated with GERD, such as esophageal adenocarcinoma, as well as costs to healthcare systems and employers. SN - 1542-7714 UR - https://www.unboundmedicine.com/medline/citation/17142109/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-3565(06)00944-X DB - PRIME DP - Unbound Medicine ER -