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Time trends of gastroesophageal reflux disease: a systematic review.

Abstract

There is a perception that the prevalence of gastroesophageal reflux disease (GERD) is increasing, but few studies have directly tackled this issue. By using a systematic approach, this review aimed to assess objectively whether the prevalence of GERD is changing with time. First, population-based studies that reported the prevalence of at least weekly heartburn and/or acid regurgitation were subjected to a time-trend analysis with a Poisson regression model. Second, population-based studies reporting the prevalence of GERD symptoms at 2 time points in the same source population were reviewed. Third, longitudinal studies that charted the prevalence of GERD symptoms and esophagitis in primary and secondary care were examined. The Poisson model revealed a significant (P < .0001) trend for an increase in the prevalence of reflux symptoms in the general population over time. Separately, significant increases with time were found for North America (P = .0005) and Europe (P < .0001) but not Asia (P = .49). Studies of the same source population over time indicated an increase in the prevalence of GERD in the U.S., Singapore, and China but not Sweden. An increase in the prevalence of GERD or esophagitis was found in the majority of longitudinal studies. There is evidence that the prevalence of GERD has increased during the past 2 decades. If this trend continues, it could contribute to the rapidly increasing incidence of more serious complications associated with GERD, such as esophageal adenocarcinoma, as well as costs to healthcare systems and employers.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    Gastroenterology and Health Services Research Sections, Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA. hasheme@bcm.tmc.edu

    Source

    MeSH

    Esophagitis, Peptic
    Gastroesophageal Reflux
    Global Health
    Heartburn
    Humans
    Poisson Distribution
    Prevalence
    Research Design

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    17142109

    Citation

    El-Serag, Hashem B.. "Time Trends of Gastroesophageal Reflux Disease: a Systematic Review." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 5, no. 1, 2007, pp. 17-26.
    El-Serag HB. Time trends of gastroesophageal reflux disease: a systematic review. Clin Gastroenterol Hepatol. 2007;5(1):17-26.
    El-Serag, H. B. (2007). Time trends of gastroesophageal reflux disease: a systematic review. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 5(1), pp. 17-26.
    El-Serag HB. Time Trends of Gastroesophageal Reflux Disease: a Systematic Review. Clin Gastroenterol Hepatol. 2007;5(1):17-26. PubMed PMID: 17142109.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Time trends of gastroesophageal reflux disease: a systematic review. A1 - El-Serag,Hashem B, Y1 - 2006/12/04/ PY - 2006/12/5/pubmed PY - 2007/4/4/medline PY - 2006/12/5/entrez SP - 17 EP - 26 JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin. Gastroenterol. Hepatol. VL - 5 IS - 1 N2 - There is a perception that the prevalence of gastroesophageal reflux disease (GERD) is increasing, but few studies have directly tackled this issue. By using a systematic approach, this review aimed to assess objectively whether the prevalence of GERD is changing with time. First, population-based studies that reported the prevalence of at least weekly heartburn and/or acid regurgitation were subjected to a time-trend analysis with a Poisson regression model. Second, population-based studies reporting the prevalence of GERD symptoms at 2 time points in the same source population were reviewed. Third, longitudinal studies that charted the prevalence of GERD symptoms and esophagitis in primary and secondary care were examined. The Poisson model revealed a significant (P < .0001) trend for an increase in the prevalence of reflux symptoms in the general population over time. Separately, significant increases with time were found for North America (P = .0005) and Europe (P < .0001) but not Asia (P = .49). Studies of the same source population over time indicated an increase in the prevalence of GERD in the U.S., Singapore, and China but not Sweden. An increase in the prevalence of GERD or esophagitis was found in the majority of longitudinal studies. There is evidence that the prevalence of GERD has increased during the past 2 decades. If this trend continues, it could contribute to the rapidly increasing incidence of more serious complications associated with GERD, such as esophageal adenocarcinoma, as well as costs to healthcare systems and employers. SN - 1542-7714 UR - https://www.unboundmedicine.com/medline/citation/17142109/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-3565(06)00944-X DB - PRIME DP - Unbound Medicine ER -