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Corticosteroids are not present in a traditional Chinese medicine formulation for atopic dermatitis in children.

Abstract

INTRODUCTION

Traditional Chinese medicine (TCM) has been used as an alternative in treating children with atopic dermatitis (AD) but its efficacy and potential side effects are debatable. We recently used a TCM capsule (PentaHerbs) on 9 children and observed significant reductions in clinical scores of disease severity. However, there have been concerns that the therapeutic effects of many forms of TCM are due to the presence of corticosteroids. The purpose of this study was to evaluate if common corticosteroids are present in PentaHerbs capsules.

MATERIALS AND METHODS

PentaHerbs powder was analysed with thin-layer chromatography, infra-red spectrophotometry and liquid chromatography mass spectrometry.

RESULTS

Hydrocortisone, prednisolone, fludrocortisone and dexamethasone were not detected in the PentaHerbs capsules.

CONCLUSION

Corticosteroids are not present in the 5 familiar herbs that were earlier shown to have efficacy on AD.

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  • Authors+Show Affiliations

    ,

    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China. ehon@cuhk.edu.hk

    , , , , ,

    Source

    MeSH

    Child
    Chromatography, Thin Layer
    Dermatitis, Atopic
    Drug Combinations
    Drugs, Chinese Herbal
    Glucocorticoids
    Humans
    Mass Spectrometry
    Pilot Projects
    Spectrophotometry, Infrared

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17160188

    Citation

    Hon, Kam Lun E., et al. "Corticosteroids Are Not Present in a Traditional Chinese Medicine Formulation for Atopic Dermatitis in Children." Annals of the Academy of Medicine, Singapore, vol. 35, no. 11, 2006, pp. 759-63.
    Hon KL, Lee VW, Leung TF, et al. Corticosteroids are not present in a traditional Chinese medicine formulation for atopic dermatitis in children. Ann Acad Med Singap. 2006;35(11):759-63.
    Hon, K. L., Lee, V. W., Leung, T. F., Lee, K. K., Chan, A. K., Fok, T. F., & Leung, P. C. (2006). Corticosteroids are not present in a traditional Chinese medicine formulation for atopic dermatitis in children. Annals of the Academy of Medicine, Singapore, 35(11), pp. 759-63.
    Hon KL, et al. Corticosteroids Are Not Present in a Traditional Chinese Medicine Formulation for Atopic Dermatitis in Children. Ann Acad Med Singap. 2006;35(11):759-63. PubMed PMID: 17160188.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Corticosteroids are not present in a traditional Chinese medicine formulation for atopic dermatitis in children. AU - Hon,Kam Lun E, AU - Lee,Vivian W Y, AU - Leung,Ting-Fan, AU - Lee,Kenneth K C, AU - Chan,Andrew K W, AU - Fok,Tai-Fai, AU - Leung,Ping-Chung, PY - 2006/12/13/pubmed PY - 2007/3/14/medline PY - 2006/12/13/entrez SP - 759 EP - 63 JF - Annals of the Academy of Medicine, Singapore JO - Ann. Acad. Med. Singap. VL - 35 IS - 11 N2 - INTRODUCTION: Traditional Chinese medicine (TCM) has been used as an alternative in treating children with atopic dermatitis (AD) but its efficacy and potential side effects are debatable. We recently used a TCM capsule (PentaHerbs) on 9 children and observed significant reductions in clinical scores of disease severity. However, there have been concerns that the therapeutic effects of many forms of TCM are due to the presence of corticosteroids. The purpose of this study was to evaluate if common corticosteroids are present in PentaHerbs capsules. MATERIALS AND METHODS: PentaHerbs powder was analysed with thin-layer chromatography, infra-red spectrophotometry and liquid chromatography mass spectrometry. RESULTS: Hydrocortisone, prednisolone, fludrocortisone and dexamethasone were not detected in the PentaHerbs capsules. CONCLUSION: Corticosteroids are not present in the 5 familiar herbs that were earlier shown to have efficacy on AD. SN - 0304-4602 UR - https://www.unboundmedicine.com/medline/citation/17160188/full_citation L2 - http://www.annals.edu.sg/pdf/35VolNo11Nov2006/V35N11p759.pdf DB - PRIME DP - Unbound Medicine ER -