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Assessment of dietary nutrients that influence perception of intra-oesophageal acid reflux events in patients with gastro-oesophageal reflux disease.

Abstract

BACKGROUND

Gastro-oesophageal reflux disease symptoms are most commonly reported postprandially, suggesting that some diet components are likely to induce symptoms more than others.

AIMS

To determine which of the various dietary nutrients is a strong predictive factor for symptom generation in association with an acid reflux event.

METHODS

Subjects with typical heartburn symptoms were evaluated by the gastro-oesophageal reflux disease Symptom Checklist, demographics questionnaire, upper endoscopy and pH testing. During the pH study, patients completed a detailed 24-h dietary intake record. This included time of meals, description of food components and the amount and type of food preparation.

RESULTS

Fifty gastro-oesophageal reflux disease patients completed all stages of the study. A total of 112 (78%) symptoms were considered as sensed reflux event. Body mass index did not correlate with having perceived reflux. Patients who consumed more cholesterol, saturated fatty acids and had more percentage calories from fat were significantly more likely to experience a perceived reflux event. Regression analysis and beta-coefficient were specifically significant for cholesterol.

CONCLUSION

Of all dietary nutrients, cholesterol enhances the most the perception of intra-oesophageal acid reflux events in patients with gastro-oesophageal reflux disease.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Section of Gastroenterology, The Neuro-Enteric Clinical Research Group, Southern Arizona VA Health Care System, AZ 85723-0001, USA.

    , , , , , ,

    Source

    Alimentary pharmacology & therapeutics 25:1 2007 Jan 01 pg 93-101

    MeSH

    Adult
    Aged
    Body Mass Index
    Diet
    Female
    Gastroesophageal Reflux
    Humans
    Male
    Middle Aged
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17229224

    Citation

    Shapiro, M, et al. "Assessment of Dietary Nutrients That Influence Perception of Intra-oesophageal Acid Reflux Events in Patients With Gastro-oesophageal Reflux Disease." Alimentary Pharmacology & Therapeutics, vol. 25, no. 1, 2007, pp. 93-101.
    Shapiro M, Green C, Bautista JM, et al. Assessment of dietary nutrients that influence perception of intra-oesophageal acid reflux events in patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2007;25(1):93-101.
    Shapiro, M., Green, C., Bautista, J. M., Dekel, R., Risner-Adler, S., Whitacre, R., ... Fass, R. (2007). Assessment of dietary nutrients that influence perception of intra-oesophageal acid reflux events in patients with gastro-oesophageal reflux disease. Alimentary Pharmacology & Therapeutics, 25(1), pp. 93-101.
    Shapiro M, et al. Assessment of Dietary Nutrients That Influence Perception of Intra-oesophageal Acid Reflux Events in Patients With Gastro-oesophageal Reflux Disease. Aliment Pharmacol Ther. 2007 Jan 1;25(1):93-101. PubMed PMID: 17229224.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Assessment of dietary nutrients that influence perception of intra-oesophageal acid reflux events in patients with gastro-oesophageal reflux disease. AU - Shapiro,M, AU - Green,C, AU - Bautista,J M, AU - Dekel,R, AU - Risner-Adler,S, AU - Whitacre,R, AU - Graver,E, AU - Fass,R, PY - 2007/1/19/pubmed PY - 2007/6/30/medline PY - 2007/1/19/entrez SP - 93 EP - 101 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 25 IS - 1 N2 - BACKGROUND: Gastro-oesophageal reflux disease symptoms are most commonly reported postprandially, suggesting that some diet components are likely to induce symptoms more than others. AIMS: To determine which of the various dietary nutrients is a strong predictive factor for symptom generation in association with an acid reflux event. METHODS: Subjects with typical heartburn symptoms were evaluated by the gastro-oesophageal reflux disease Symptom Checklist, demographics questionnaire, upper endoscopy and pH testing. During the pH study, patients completed a detailed 24-h dietary intake record. This included time of meals, description of food components and the amount and type of food preparation. RESULTS: Fifty gastro-oesophageal reflux disease patients completed all stages of the study. A total of 112 (78%) symptoms were considered as sensed reflux event. Body mass index did not correlate with having perceived reflux. Patients who consumed more cholesterol, saturated fatty acids and had more percentage calories from fat were significantly more likely to experience a perceived reflux event. Regression analysis and beta-coefficient were specifically significant for cholesterol. CONCLUSION: Of all dietary nutrients, cholesterol enhances the most the perception of intra-oesophageal acid reflux events in patients with gastro-oesophageal reflux disease. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/17229224/full_citation L2 - https://doi.org/10.1111/j.1365-2036.2006.03170.x DB - PRIME DP - Unbound Medicine ER -