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Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies.
Am J Respir Crit Care Med 2007; 175(7):661-6AJ

Abstract

RATIONALE

Although obesity has been implicated as an asthma risk factor, there is heterogeneity in the published literature regarding its role in asthma incidence, particularly in men.

OBJECTIVES

To quantify the relationship between categories of body mass index (BMI) and incident asthma in adults and to evaluate the impact of sex on this relationship.

METHODS

Online bibliographic databases were searched for prospective studies evaluating BMI and incident asthma in adults. Independent observers extracted data regarding annualized asthma incidence from studies meeting predetermined criteria, within defined categories of normal weight (BMI < 25), overweight (BMI, 25-29.9), and obesity (BMI >or= 30). Data were analyzed by inverse-variance-weighted, random-effects meta-analysis. Stratified analysis between BMI categories and within sex was performed.

RESULTS

Seven studies (n=333,102 subjects) met inclusion criteria. Compared with normal weight, overweight and obesity (BMI >or= 25) conferred increased odds of incident asthma, with an odds ratio (OR) of 1.51 (95% confidence interval [CI], 1.27-1.80). A dose-response effect of elevated BMI on asthma incidence was observed; the OR for incident asthma for normal-weight versus overweight subjects was 1.38 (95% CI, 1.17-1.62) and was further elevated for normal weight versus obesity (OR, 1.92; 95% CI, 1.43-2.59; p<0.0001 for the trend). A similar increase in the OR of incident asthma due to overweight and obesity was observed in men (OR, 1.46; 95% CI, 1.05-2.02) and women (OR, 1.68; 95% CI, 1.45-1.94; p=0.232 for the comparison).

CONCLUSIONS

Overweight and obesity are associated with a dose-dependent increase in the odds of incident asthma in men and women, suggesting asthma incidence could be reduced by interventions targeting overweight and obesity.

Authors+Show Affiliations

Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, J220, Denver, CO 80206, USA.No affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

17234901

Citation

Beuther, David A., and E Rand Sutherland. "Overweight, Obesity, and Incident Asthma: a Meta-analysis of Prospective Epidemiologic Studies." American Journal of Respiratory and Critical Care Medicine, vol. 175, no. 7, 2007, pp. 661-6.
Beuther DA, Sutherland ER. Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med. 2007;175(7):661-6.
Beuther, D. A., & Sutherland, E. R. (2007). Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. American Journal of Respiratory and Critical Care Medicine, 175(7), pp. 661-6.
Beuther DA, Sutherland ER. Overweight, Obesity, and Incident Asthma: a Meta-analysis of Prospective Epidemiologic Studies. Am J Respir Crit Care Med. 2007 Apr 1;175(7):661-6. PubMed PMID: 17234901.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. AU - Beuther,David A, AU - Sutherland,E Rand, Y1 - 2007/01/18/ PY - 2007/1/20/pubmed PY - 2007/5/16/medline PY - 2007/1/20/entrez SP - 661 EP - 6 JF - American journal of respiratory and critical care medicine JO - Am. J. Respir. Crit. Care Med. VL - 175 IS - 7 N2 - RATIONALE: Although obesity has been implicated as an asthma risk factor, there is heterogeneity in the published literature regarding its role in asthma incidence, particularly in men. OBJECTIVES: To quantify the relationship between categories of body mass index (BMI) and incident asthma in adults and to evaluate the impact of sex on this relationship. METHODS: Online bibliographic databases were searched for prospective studies evaluating BMI and incident asthma in adults. Independent observers extracted data regarding annualized asthma incidence from studies meeting predetermined criteria, within defined categories of normal weight (BMI < 25), overweight (BMI, 25-29.9), and obesity (BMI >or= 30). Data were analyzed by inverse-variance-weighted, random-effects meta-analysis. Stratified analysis between BMI categories and within sex was performed. RESULTS: Seven studies (n=333,102 subjects) met inclusion criteria. Compared with normal weight, overweight and obesity (BMI >or= 25) conferred increased odds of incident asthma, with an odds ratio (OR) of 1.51 (95% confidence interval [CI], 1.27-1.80). A dose-response effect of elevated BMI on asthma incidence was observed; the OR for incident asthma for normal-weight versus overweight subjects was 1.38 (95% CI, 1.17-1.62) and was further elevated for normal weight versus obesity (OR, 1.92; 95% CI, 1.43-2.59; p<0.0001 for the trend). A similar increase in the OR of incident asthma due to overweight and obesity was observed in men (OR, 1.46; 95% CI, 1.05-2.02) and women (OR, 1.68; 95% CI, 1.45-1.94; p=0.232 for the comparison). CONCLUSIONS: Overweight and obesity are associated with a dose-dependent increase in the odds of incident asthma in men and women, suggesting asthma incidence could be reduced by interventions targeting overweight and obesity. SN - 1073-449X UR - https://www.unboundmedicine.com/medline/citation/17234901/full_citation L2 - http://www.atsjournals.org/doi/full/10.1164/rccm.200611-1717OC?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -