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Nutritional status determinants and cognition in the elderly.
Arch Gerontol Geriatr 2007; 44 Suppl 1:143-53AG

Abstract

It is possible to identify risks or protective factors against dementia. Increased levels of homocysteine (HCY) and vitamin B deficiency, obesity and central adiposity in midlife are independent risk factors for the development of dementia. High dietary intake of antioxidants and omega-3 fatty acids lower the risk of Alzheimer disease (AD). The supplementation with single nutrients, like vitamin B, omega-3-polyunsaturated fatty acids (PUFA) or antioxidants is generally not effective in lowering the risk of dementia or in slowing the progression of the disease. It is probably necessary that these nutrients are part of a healthy diet (with at least five portions of fruit and vegetables per day and one portion of fish per week) during the lite where other factors interact with them as it happens in the Mediterranean diet. Nutritional strategies for modifying the clinical course of cognitive failure should consider the use of nutritional screening tools in the multidimensional geriatric evaluation. Moreover, the diet, oral supplementation, caregiver education could be important factors to prevent or treat weight loss and its consequences in AD while the use of artificial nutrition in demented patients may have questionable benefits.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Donini LM
    Istituto di Scienza dell'Alimentazione, Universita dà Roma La Sapienza, Pie Aldo Moro, Roma, Italy. Lorenzomaria.Donini@uniroma1.it
    De Felice MR
    No affiliation info available
    Cannella C
    No affiliation info available

    MeSH

    AgedAged, 80 and overAntioxidantsAvitaminosisCognition DisordersComorbidityHumansHyperhomocysteinemiaMass ScreeningNutritional StatusObesityPrevalenceWeight Lossbeta-Thalassemia

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17317448

    Citation

    Donini, L M., et al. "Nutritional Status Determinants and Cognition in the Elderly." Archives of Gerontology and Geriatrics, vol. 44 Suppl 1, 2007, pp. 143-53.
    Donini LM, De Felice MR, Cannella C. Nutritional status determinants and cognition in the elderly. Arch Gerontol Geriatr. 2007;44 Suppl 1:143-53.
    Donini, L. M., De Felice, M. R., & Cannella, C. (2007). Nutritional status determinants and cognition in the elderly. Archives of Gerontology and Geriatrics, 44 Suppl 1, pp. 143-53.
    Donini LM, De Felice MR, Cannella C. Nutritional Status Determinants and Cognition in the Elderly. Arch Gerontol Geriatr. 2007;44 Suppl 1:143-53. PubMed PMID: 17317448.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Nutritional status determinants and cognition in the elderly. AU - Donini,L M, AU - De Felice,M R, AU - Cannella,C, PY - 2007/2/24/pubmed PY - 2007/5/19/medline PY - 2007/2/24/entrez SP - 143 EP - 53 JF - Archives of gerontology and geriatrics JO - Arch Gerontol Geriatr VL - 44 Suppl 1 N2 - It is possible to identify risks or protective factors against dementia. Increased levels of homocysteine (HCY) and vitamin B deficiency, obesity and central adiposity in midlife are independent risk factors for the development of dementia. High dietary intake of antioxidants and omega-3 fatty acids lower the risk of Alzheimer disease (AD). The supplementation with single nutrients, like vitamin B, omega-3-polyunsaturated fatty acids (PUFA) or antioxidants is generally not effective in lowering the risk of dementia or in slowing the progression of the disease. It is probably necessary that these nutrients are part of a healthy diet (with at least five portions of fruit and vegetables per day and one portion of fish per week) during the lite where other factors interact with them as it happens in the Mediterranean diet. Nutritional strategies for modifying the clinical course of cognitive failure should consider the use of nutritional screening tools in the multidimensional geriatric evaluation. Moreover, the diet, oral supplementation, caregiver education could be important factors to prevent or treat weight loss and its consequences in AD while the use of artificial nutrition in demented patients may have questionable benefits. SN - 0167-4943 UR - https://www.unboundmedicine.com/medline/citation/17317448/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-4943(07)00023-4 DB - PRIME DP - Unbound Medicine ER -