Tags

Type your tag names separated by a space and hit enter

Vitamin D and prevention of breast cancer: pooled analysis.

Abstract

BACKGROUND

Inadequate photosynthesis or oral intake of Vitamin D are associated with high incidence and mortality rates of breast cancer in ecological and observational studies, but the dose-response relationship in individuals has not been adequately studied.

METHODS

A literature search for all studies that reported risk by of breast cancer by quantiles of 25(OH)D identified two studies with 1760 individuals. Data were pooled to assess the dose-response association between serum 25(OH)D and risk of breast cancer.

RESULTS

The medians of the pooled quintiles of serum 25(OH)D were 6, 18, 29, 37 and 48 ng/ml. Pooled odds ratios for breast cancer from lowest to highest quintile, were 1.00, 0.90, 0.70, 0.70 and 0.50 (p trend<0.001). According to the pooled analysis, individuals with serum 25(OH)D of approximately 52 ng/ml had 50% lower risk of breast cancer than those with serum <13 ng/ml. This serum level corresponds to intake of 4000 IU/day. This exceeds the National Academy of Sciences upper limit of 2000 IU/day. A 25(OH)D level of 52 ng/ml could be maintained by intake of 2000 IU/day and, when appropriate, about 12 min/day in the sun, equivalent to oral intake of 3000 IU of Vitamin D(3).

CONCLUSIONS

Intake of 2000 IU/day of Vitamin D(3), and, when possible, very moderate exposure to sunlight, could raise serum 25(OH)D to 52 ng/ml, a level associated with reduction by 50% in incidence of breast cancer, according to observational studies.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Family and Preventive Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. cgarland@ucsd.edu

    , , , , , , ,

    Source

    MeSH

    Administration, Oral
    Breast Neoplasms
    Humans
    Risk Factors
    Vitamin D

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17368188

    Citation

    Garland, Cedric F., et al. "Vitamin D and Prevention of Breast Cancer: Pooled Analysis." The Journal of Steroid Biochemistry and Molecular Biology, vol. 103, no. 3-5, 2007, pp. 708-11.
    Garland CF, Gorham ED, Mohr SB, et al. Vitamin D and prevention of breast cancer: pooled analysis. J Steroid Biochem Mol Biol. 2007;103(3-5):708-11.
    Garland, C. F., Gorham, E. D., Mohr, S. B., Grant, W. B., Giovannucci, E. L., Lipkin, M., ... Garland, F. C. (2007). Vitamin D and prevention of breast cancer: pooled analysis. The Journal of Steroid Biochemistry and Molecular Biology, 103(3-5), pp. 708-11.
    Garland CF, et al. Vitamin D and Prevention of Breast Cancer: Pooled Analysis. J Steroid Biochem Mol Biol. 2007;103(3-5):708-11. PubMed PMID: 17368188.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin D and prevention of breast cancer: pooled analysis. AU - Garland,Cedric F, AU - Gorham,Edward D, AU - Mohr,Sharif B, AU - Grant,William B, AU - Giovannucci,Edward L, AU - Lipkin,Martin, AU - Newmark,Harold, AU - Holick,Michael F, AU - Garland,Frank C, PY - 2007/3/21/pubmed PY - 2007/5/12/medline PY - 2007/3/21/entrez SP - 708 EP - 11 JF - The Journal of steroid biochemistry and molecular biology JO - J. Steroid Biochem. Mol. Biol. VL - 103 IS - 3-5 N2 - BACKGROUND: Inadequate photosynthesis or oral intake of Vitamin D are associated with high incidence and mortality rates of breast cancer in ecological and observational studies, but the dose-response relationship in individuals has not been adequately studied. METHODS: A literature search for all studies that reported risk by of breast cancer by quantiles of 25(OH)D identified two studies with 1760 individuals. Data were pooled to assess the dose-response association between serum 25(OH)D and risk of breast cancer. RESULTS: The medians of the pooled quintiles of serum 25(OH)D were 6, 18, 29, 37 and 48 ng/ml. Pooled odds ratios for breast cancer from lowest to highest quintile, were 1.00, 0.90, 0.70, 0.70 and 0.50 (p trend<0.001). According to the pooled analysis, individuals with serum 25(OH)D of approximately 52 ng/ml had 50% lower risk of breast cancer than those with serum <13 ng/ml. This serum level corresponds to intake of 4000 IU/day. This exceeds the National Academy of Sciences upper limit of 2000 IU/day. A 25(OH)D level of 52 ng/ml could be maintained by intake of 2000 IU/day and, when appropriate, about 12 min/day in the sun, equivalent to oral intake of 3000 IU of Vitamin D(3). CONCLUSIONS: Intake of 2000 IU/day of Vitamin D(3), and, when possible, very moderate exposure to sunlight, could raise serum 25(OH)D to 52 ng/ml, a level associated with reduction by 50% in incidence of breast cancer, according to observational studies. SN - 0960-0760 UR - https://www.unboundmedicine.com/medline/citation/17368188/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-0760(06)00391-8 DB - PRIME DP - Unbound Medicine ER -