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Dietary patterns, the Alternate Healthy Eating Index and plasma sex hormone concentrations in postmenopausal women.
Int J Cancer 2007; 121(4):803-9IJ

Abstract

To evaluate the association between overall diet and sex hormones concentrations, we collected blood from 578 postmenopausal women ages 43 and 69 years in 1989 or 1990. Food intake was measured in 1990 via a food frequency questionnaire. We calculated the Alternate Healthy Eating Index (AHEI), and dietary patterns were identified by factor analysis. The cross-sectional association between diet and estrogens, sex hormone binding globulin (SHBG) were evaluated with linear regression and adjusted for energy and other potential confounders. We found a higher AHEI score was associated with lower concentrations of estradiol, free estradiol, and higher concentrations of SHBG. The prudent pattern, with higher intakes of fruits, vegetables, and whole grains, was not associated with any sex hormones. The Western pattern, which represents higher intakes of red and processed meats, refined grains, sweets and desserts, was associated with a higher level of estradiol and lower concentrations of SHBG. Further adjustment for BMI attenuated these results except for free estradiol (5th vs. 1st quintile = 0.09 vs. 0.11 pg/mL, p for trend = 0.03). In addition, the AHEI was inversely associated with estradiol among those with BMI > 25, and Western pattern with SHBG among those with BMI < 25. In conclusion, we observed inverse associations between the AHEI score and several estrogens, and it was positively associated with plasma levels of SHBG. In contrast, the Western pattern was positively associated with estrogen levels and inversely with SHBG. However, these associations appeared to be largely accounted for by BMI.

Authors+Show Affiliations

Department of Nutrition, Simmons College, Boston, MA 02115, USA. fung@simmons.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17455249

Citation

Fung, Teresa T., et al. "Dietary Patterns, the Alternate Healthy Eating Index and Plasma Sex Hormone Concentrations in Postmenopausal Women." International Journal of Cancer, vol. 121, no. 4, 2007, pp. 803-9.
Fung TT, Hu FB, Barbieri RL, et al. Dietary patterns, the Alternate Healthy Eating Index and plasma sex hormone concentrations in postmenopausal women. Int J Cancer. 2007;121(4):803-9.
Fung, T. T., Hu, F. B., Barbieri, R. L., Willett, W. C., & Hankinson, S. E. (2007). Dietary patterns, the Alternate Healthy Eating Index and plasma sex hormone concentrations in postmenopausal women. International Journal of Cancer, 121(4), pp. 803-9.
Fung TT, et al. Dietary Patterns, the Alternate Healthy Eating Index and Plasma Sex Hormone Concentrations in Postmenopausal Women. Int J Cancer. 2007 Aug 15;121(4):803-9. PubMed PMID: 17455249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary patterns, the Alternate Healthy Eating Index and plasma sex hormone concentrations in postmenopausal women. AU - Fung,Teresa T, AU - Hu,Frank B, AU - Barbieri,Robert L, AU - Willett,Walter C, AU - Hankinson,Susan E, PY - 2007/4/25/pubmed PY - 2007/9/13/medline PY - 2007/4/25/entrez SP - 803 EP - 9 JF - International journal of cancer JO - Int. J. Cancer VL - 121 IS - 4 N2 - To evaluate the association between overall diet and sex hormones concentrations, we collected blood from 578 postmenopausal women ages 43 and 69 years in 1989 or 1990. Food intake was measured in 1990 via a food frequency questionnaire. We calculated the Alternate Healthy Eating Index (AHEI), and dietary patterns were identified by factor analysis. The cross-sectional association between diet and estrogens, sex hormone binding globulin (SHBG) were evaluated with linear regression and adjusted for energy and other potential confounders. We found a higher AHEI score was associated with lower concentrations of estradiol, free estradiol, and higher concentrations of SHBG. The prudent pattern, with higher intakes of fruits, vegetables, and whole grains, was not associated with any sex hormones. The Western pattern, which represents higher intakes of red and processed meats, refined grains, sweets and desserts, was associated with a higher level of estradiol and lower concentrations of SHBG. Further adjustment for BMI attenuated these results except for free estradiol (5th vs. 1st quintile = 0.09 vs. 0.11 pg/mL, p for trend = 0.03). In addition, the AHEI was inversely associated with estradiol among those with BMI > 25, and Western pattern with SHBG among those with BMI < 25. In conclusion, we observed inverse associations between the AHEI score and several estrogens, and it was positively associated with plasma levels of SHBG. In contrast, the Western pattern was positively associated with estrogen levels and inversely with SHBG. However, these associations appeared to be largely accounted for by BMI. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/17455249/full_citation L2 - https://doi.org/10.1002/ijc.22728 DB - PRIME DP - Unbound Medicine ER -