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Specific formulation of Camellia sinensis prevents cold and flu symptoms and enhances gamma,delta T cell function: a randomized, double-blind, placebo-controlled study.
J Am Coll Nutr. 2007 Oct; 26(5):445-52.JA

Abstract

OBJECTIVE

Determine if a specific formulation of Camellia sinensis (CSF) can prevent illness and symptoms due to cold and flu, and enhance gammadelta T cell function

DESIGN

Randomized, double-blind, placebo-controlled study.

SUBJECTS

Healthy adults 18-70 years old.

INTERVENTION

Proprietary formulation of Camellia sinensis (green tea) capsules, or a placebo, twice a day, for 3 months.

MEASURES OF OUTCOME

As assessed by daily symptom logs, percentage of subjects experiencing cold and flu symptoms, number of days subjects experienced symptoms, and percentage of subjects seeking medical treatment. Mean in vivo and ex vivo proliferative and interferon gamma responses of subjects' peripheral blood mononuclear cells to gammadelta T cell antigen stimulation.

RESULTS

Among subjects taking CSF there were 32.1% fewer subjects with symptoms (P = 0.035), 22.9% fewer overall illnesses of at least 2 days duration (P = 0.092), and 35.6% fewer symptom days (P < 0.002), compared to subjects taking placebo. gammadelta T cells from subjects taking CSF proliferated 28% more (P = 0.017) and secreted 26% more IFN-gamma (P = 0.046) in response to gammadelta T cell antigens, as compared to gammadelta T cells from subjects taking placebo. CSF was well-tolerated.

CONCLUSIONS

This proprietary formulation of CSF is a safe and effective dietary supplement for preventing cold and flu symptoms, and for enhancing gammadelta T cell function.

Links

Publisher Full Text

Authors+Show Affiliations

Rowe CA
Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida 32611, USA.
Nantz MP
No affiliation info available
Bukowski JF
No affiliation info available
Percival SS
No affiliation info available

MeSH

AdultAgedCamellia sinensisCommon ColdDietary SupplementsDouble-Blind MethodFemaleFlow CytometryHumansImmunity, CellularInfluenza, HumanInterferon-gammaLymphocyte ActivationMaleMiddle AgedPhytotherapySeverity of Illness IndexT-LymphocytesTime FactorsTreatment Outcome

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17914132

Citation

Rowe, Cheryl A., et al. "Specific Formulation of Camellia Sinensis Prevents Cold and Flu Symptoms and Enhances Gamma,delta T Cell Function: a Randomized, Double-blind, Placebo-controlled Study." Journal of the American College of Nutrition, vol. 26, no. 5, 2007, pp. 445-52.
Rowe CA, Nantz MP, Bukowski JF, et al. Specific formulation of Camellia sinensis prevents cold and flu symptoms and enhances gamma,delta T cell function: a randomized, double-blind, placebo-controlled study. J Am Coll Nutr. 2007;26(5):445-52.
Rowe, C. A., Nantz, M. P., Bukowski, J. F., & Percival, S. S. (2007). Specific formulation of Camellia sinensis prevents cold and flu symptoms and enhances gamma,delta T cell function: a randomized, double-blind, placebo-controlled study. Journal of the American College of Nutrition, 26(5), 445-52.
Rowe CA, et al. Specific Formulation of Camellia Sinensis Prevents Cold and Flu Symptoms and Enhances Gamma,delta T Cell Function: a Randomized, Double-blind, Placebo-controlled Study. J Am Coll Nutr. 2007;26(5):445-52. PubMed PMID: 17914132.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Specific formulation of Camellia sinensis prevents cold and flu symptoms and enhances gamma,delta T cell function: a randomized, double-blind, placebo-controlled study. AU - Rowe,Cheryl A, AU - Nantz,Meri P, AU - Bukowski,Jack F, AU - Percival,Susan S, PY - 2007/10/5/pubmed PY - 2007/12/7/medline PY - 2007/10/5/entrez SP - 445 EP - 52 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 26 IS - 5 N2 - OBJECTIVE: Determine if a specific formulation of Camellia sinensis (CSF) can prevent illness and symptoms due to cold and flu, and enhance gammadelta T cell function DESIGN: Randomized, double-blind, placebo-controlled study. SUBJECTS: Healthy adults 18-70 years old. INTERVENTION: Proprietary formulation of Camellia sinensis (green tea) capsules, or a placebo, twice a day, for 3 months. MEASURES OF OUTCOME: As assessed by daily symptom logs, percentage of subjects experiencing cold and flu symptoms, number of days subjects experienced symptoms, and percentage of subjects seeking medical treatment. Mean in vivo and ex vivo proliferative and interferon gamma responses of subjects' peripheral blood mononuclear cells to gammadelta T cell antigen stimulation. RESULTS: Among subjects taking CSF there were 32.1% fewer subjects with symptoms (P = 0.035), 22.9% fewer overall illnesses of at least 2 days duration (P = 0.092), and 35.6% fewer symptom days (P < 0.002), compared to subjects taking placebo. gammadelta T cells from subjects taking CSF proliferated 28% more (P = 0.017) and secreted 26% more IFN-gamma (P = 0.046) in response to gammadelta T cell antigens, as compared to gammadelta T cells from subjects taking placebo. CSF was well-tolerated. CONCLUSIONS: This proprietary formulation of CSF is a safe and effective dietary supplement for preventing cold and flu symptoms, and for enhancing gammadelta T cell function. SN - 0731-5724 UR - https://www.unboundmedicine.com/medline/citation/17914132/full_citation L2 - https://www.tandfonline.com/doi/full/10.1080/07315724.2007.10719634 DB - PRIME DP - Unbound Medicine ER -
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