Tags

Type your tag names separated by a space and hit enter

The cholesterol paradox is flawed; cholesterol must be lowered in dialysis patients.
Semin Dial 2007 Nov-Dec; 20(6):504-9SD

Abstract

In the general population, elevated cholesterol is associated with cardiovascular disease and mortality and lowering cholesterol is associated with improved outcomes. This reflects the predominance of isolated atherosclerotic coronary disease in the general population. In patients with renal disease, however, the relationship between serum lipids and cardiovascular outcomes is much less clear and even reversed. In our opinion, the relationship between cholesterol and coronary disease is obscured by high levels of co-morbid disease, malnutrition, inflammation, atypical dyslipidemia and the fact that myocardial infarction is not the typical presentation of cardiovascular disease in patients with renal disease. Thus, cholesterol lowering will still be effective in patients with chronic kidney diseases.

Authors+Show Affiliations

BHF Cardiovascular Research Centre, University of Glasgow, and Renal Transplant Unit, Western Infirmary, Glasgow, United Kingdom.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17991195

Citation

Wan, Ray K., et al. "The Cholesterol Paradox Is Flawed; Cholesterol Must Be Lowered in Dialysis Patients." Seminars in Dialysis, vol. 20, no. 6, 2007, pp. 504-9.
Wan RK, Mark PB, Jardine AG. The cholesterol paradox is flawed; cholesterol must be lowered in dialysis patients. Semin Dial. 2007;20(6):504-9.
Wan, R. K., Mark, P. B., & Jardine, A. G. (2007). The cholesterol paradox is flawed; cholesterol must be lowered in dialysis patients. Seminars in Dialysis, 20(6), pp. 504-9.
Wan RK, Mark PB, Jardine AG. The Cholesterol Paradox Is Flawed; Cholesterol Must Be Lowered in Dialysis Patients. Semin Dial. 2007;20(6):504-9. PubMed PMID: 17991195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cholesterol paradox is flawed; cholesterol must be lowered in dialysis patients. AU - Wan,Ray K, AU - Mark,Patrick B, AU - Jardine,Alan G, PY - 2007/11/10/pubmed PY - 2008/2/2/medline PY - 2007/11/10/entrez SP - 504 EP - 9 JF - Seminars in dialysis JO - Semin Dial VL - 20 IS - 6 N2 - In the general population, elevated cholesterol is associated with cardiovascular disease and mortality and lowering cholesterol is associated with improved outcomes. This reflects the predominance of isolated atherosclerotic coronary disease in the general population. In patients with renal disease, however, the relationship between serum lipids and cardiovascular outcomes is much less clear and even reversed. In our opinion, the relationship between cholesterol and coronary disease is obscured by high levels of co-morbid disease, malnutrition, inflammation, atypical dyslipidemia and the fact that myocardial infarction is not the typical presentation of cardiovascular disease in patients with renal disease. Thus, cholesterol lowering will still be effective in patients with chronic kidney diseases. SN - 0894-0959 UR - https://www.unboundmedicine.com/medline/citation/17991195/full_citation L2 - https://doi.org/10.1111/j.1525-139X.2007.00359.x DB - PRIME DP - Unbound Medicine ER -