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Onion and garlic intake and the odds of benign prostatic hyperplasia.

Abstract

OBJECTIVE

To analyze the relationship between onion and garlic intake and benign prostatic hyperplasia (BPH), using data from a multicenter case-control study conducted in Italy.

METHODS

A multicenter case-control study of 1369 patients with BPH and 1451 controls, admitted to the same hospitals for a wide spectrum of acute, non-neoplastic conditions, was conducted in Italy between 1991 and 2002. Information was collected by trained interviewers using a validated and reproducible food frequency questionnaire. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were obtained after allowance for recognized confounding factors and energy intake.

RESULTS

Compared with nonusers, the multivariate ORs for the highest category of onion and garlic intake were 0.41 (95% CI 0.24 to 0.72) and 0.72 (95% CI 0.57 to 0.91), respectively. The combined OR for frequent users versus nonusers of both onion and garlic was 0.65 (95% CI 0.49 to 0.86). The inverse relationships were consistent across age strata.

CONCLUSIONS

This uniquely large data set from European populations showed an inverse association between allium vegetable consumption and BPH.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

    , , , , , , ,

    Source

    Urology 70:4 2007 Oct pg 672-6

    MeSH

    Aged
    Case-Control Studies
    Diet
    Garlic
    Humans
    Male
    Middle Aged
    Odds Ratio
    Onions
    Prostatic Hyperplasia

    Pub Type(s)

    Journal Article
    Multicenter Study

    Language

    eng

    PubMed ID

    17991535

    Citation

    Galeone, Carlotta, et al. "Onion and Garlic Intake and the Odds of Benign Prostatic Hyperplasia." Urology, vol. 70, no. 4, 2007, pp. 672-6.
    Galeone C, Pelucchi C, Talamini R, et al. Onion and garlic intake and the odds of benign prostatic hyperplasia. Urology. 2007;70(4):672-6.
    Galeone, C., Pelucchi, C., Talamini, R., Negri, E., Dal Maso, L., Montella, M., ... La Vecchia, C. (2007). Onion and garlic intake and the odds of benign prostatic hyperplasia. Urology, 70(4), pp. 672-6.
    Galeone C, et al. Onion and Garlic Intake and the Odds of Benign Prostatic Hyperplasia. Urology. 2007;70(4):672-6. PubMed PMID: 17991535.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Onion and garlic intake and the odds of benign prostatic hyperplasia. AU - Galeone,Carlotta, AU - Pelucchi,Claudio, AU - Talamini,Renato, AU - Negri,Eva, AU - Dal Maso,Luigino, AU - Montella,Maurizio, AU - Ramazzotti,Valerio, AU - Franceschi,Silvia, AU - La Vecchia,Carlo, PY - 2006/11/29/received PY - 2007/04/16/revised PY - 2007/06/26/accepted PY - 2007/11/10/pubmed PY - 2007/12/15/medline PY - 2007/11/10/entrez SP - 672 EP - 6 JF - Urology JO - Urology VL - 70 IS - 4 N2 - OBJECTIVE: To analyze the relationship between onion and garlic intake and benign prostatic hyperplasia (BPH), using data from a multicenter case-control study conducted in Italy. METHODS: A multicenter case-control study of 1369 patients with BPH and 1451 controls, admitted to the same hospitals for a wide spectrum of acute, non-neoplastic conditions, was conducted in Italy between 1991 and 2002. Information was collected by trained interviewers using a validated and reproducible food frequency questionnaire. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were obtained after allowance for recognized confounding factors and energy intake. RESULTS: Compared with nonusers, the multivariate ORs for the highest category of onion and garlic intake were 0.41 (95% CI 0.24 to 0.72) and 0.72 (95% CI 0.57 to 0.91), respectively. The combined OR for frequent users versus nonusers of both onion and garlic was 0.65 (95% CI 0.49 to 0.86). The inverse relationships were consistent across age strata. CONCLUSIONS: This uniquely large data set from European populations showed an inverse association between allium vegetable consumption and BPH. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/17991535/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(07)01778-5 DB - PRIME DP - Unbound Medicine ER -