Type your tag names separated by a space and hit enter

Relationship between obesity and uterine leiomyomata.

Abstract

Obesity is associated with many comorbid disease states including neoplasia. The increased risk of developing endometrial cancer is thought to be due to the higher level of circulating estrogens in obese women. Uterine leiomyomata (fibroids) are also thought to be influenced by estrogens. To determine whether patients presenting with symptomatic uterine fibroids were more obese than the general population, we retrospectively reviewed the hospital records of 144 women who underwent either hysterectomy or myomectomy for uterine fibroids. Obesity was defined as preoperative weight greater than 120% of desirable body weight (DBW) for the patient's height. In our investigation, 51% of the study population were obese. Moreover, 16% were severely obese (defined as greater than 150% DBW). When compared with the general population of women in the United States matched for height and age, the study population was significantly heavier. (p less than 0.0002). Patient age, parity, menopausal status, and degree of obesity did not correlate with the number of fibroids within the uterus. Fibroid size was significantly larger in nulliparous women (p less than 0.005). These results suggest that symptomatic uterine fibroids may be another comorbid disease state associated with obesity.

Authors+Show Affiliations

,

Nutrition Support Service, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215.

, , ,

Source

MeSH

Adult
Body Weight
Female
Humans
Hysterectomy
Leiomyoma
Menopause
Middle Aged
Obesity
Retrospective Studies
Uterine Neoplasms

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1802214

Citation

Shikora, S A., et al. "Relationship Between Obesity and Uterine Leiomyomata." Nutrition (Burbank, Los Angeles County, Calif.), vol. 7, no. 4, 1991, pp. 251-5.
Shikora SA, Niloff JM, Bistrian BR, et al. Relationship between obesity and uterine leiomyomata. Nutrition. 1991;7(4):251-5.
Shikora, S. A., Niloff, J. M., Bistrian, B. R., Forse, R. A., & Blackburn, G. L. (1991). Relationship between obesity and uterine leiomyomata. Nutrition (Burbank, Los Angeles County, Calif.), 7(4), pp. 251-5.
Shikora SA, et al. Relationship Between Obesity and Uterine Leiomyomata. Nutrition. 1991;7(4):251-5. PubMed PMID: 1802214.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between obesity and uterine leiomyomata. AU - Shikora,S A, AU - Niloff,J M, AU - Bistrian,B R, AU - Forse,R A, AU - Blackburn,G L, PY - 1991/7/1/pubmed PY - 1991/7/1/medline PY - 1991/7/1/entrez SP - 251 EP - 5 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 7 IS - 4 N2 - Obesity is associated with many comorbid disease states including neoplasia. The increased risk of developing endometrial cancer is thought to be due to the higher level of circulating estrogens in obese women. Uterine leiomyomata (fibroids) are also thought to be influenced by estrogens. To determine whether patients presenting with symptomatic uterine fibroids were more obese than the general population, we retrospectively reviewed the hospital records of 144 women who underwent either hysterectomy or myomectomy for uterine fibroids. Obesity was defined as preoperative weight greater than 120% of desirable body weight (DBW) for the patient's height. In our investigation, 51% of the study population were obese. Moreover, 16% were severely obese (defined as greater than 150% DBW). When compared with the general population of women in the United States matched for height and age, the study population was significantly heavier. (p less than 0.0002). Patient age, parity, menopausal status, and degree of obesity did not correlate with the number of fibroids within the uterus. Fibroid size was significantly larger in nulliparous women (p less than 0.005). These results suggest that symptomatic uterine fibroids may be another comorbid disease state associated with obesity. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/1802214/full_citation L2 - http://www.diseaseinfosearch.org/result/9028 DB - PRIME DP - Unbound Medicine ER -