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Body mass index and diverticular disease: a 28-year follow-up study in men.

Abstract

PURPOSE

Diverticular disease increased steadily concomitant with elevated rates of overweight and obesity during the 20th century. Therefore, the objective of this study was to investigate whether overweight and obesity in midlife predict future diverticular disease in men.

METHODS

This was a prospective cohort study of a general population of men living in Göteborg, Sweden. A community-based sample of 7,494 men, investigated when aged 47 to 55 years, were followed from baseline in 1970 to 1973 for a maximum of 28 years. Hospitalization with a discharge diagnosis of diverticular disease according to the Swedish hospital discharge register was measured.

RESULTS

Totally, 112 men (1.5 percent) were hospitalized with diverticular disease. A relationship between body mass index and diverticular disease was demonstrated; men with a body mass index between 20 and 22.5 kg/m2 had the lowest risk. After adjustment for covariates, the risk increased linearly in men who had a body mass index of 22.5 to 25 (multiple-adjusted hazard ratio, 2.3; 95 percent confidence interval, 0.9-6; 25-27.5 (hazard ratio, 3 (1.2-7.6)), 27.5-30 (hazard ratio 3.2, (1.2-8.6)), and 30 or greater (hazard ratio 4.4, (1.6-12.3)) kg/m2 (P for linear trend = 0.004). Men with a body mass index of < or =20 kg/m2 had a nonsignificantly elevated risk (hazard ratio, 3 (0.7-12.5)). Smoking (hazard ratio, 1.6 (1.1-2.3) and diastolic blood pressure (hazard ratio, 1.02 (1.01-1.04) per mmHg) also were independently related to risk of diverticular disease.

CONCLUSIONS

In a large community-based sample of middle-aged men, overweight and obesity were strongly linked to future severe diverticular disease leading to hospitalization.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Surgery, Sahlgrenska University Hospital/Ostra, SE-416 85, Göteborg, Sweden. anders.rosemar@vgregion.se

    ,

    Source

    Diseases of the colon and rectum 51:4 2008 Apr pg 450-5

    MeSH

    Body Mass Index
    Confidence Intervals
    Disease Progression
    Diverticulum
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Obesity
    Prevalence
    Prognosis
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Severity of Illness Index
    Survival Rate
    Sweden
    Time Factors

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18157570

    Citation

    Rosemar, Anders, et al. "Body Mass Index and Diverticular Disease: a 28-year Follow-up Study in Men." Diseases of the Colon and Rectum, vol. 51, no. 4, 2008, pp. 450-5.
    Rosemar A, Angerås U, Rosengren A. Body mass index and diverticular disease: a 28-year follow-up study in men. Dis Colon Rectum. 2008;51(4):450-5.
    Rosemar, A., Angerås, U., & Rosengren, A. (2008). Body mass index and diverticular disease: a 28-year follow-up study in men. Diseases of the Colon and Rectum, 51(4), pp. 450-5.
    Rosemar A, Angerås U, Rosengren A. Body Mass Index and Diverticular Disease: a 28-year Follow-up Study in Men. Dis Colon Rectum. 2008;51(4):450-5. PubMed PMID: 18157570.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Body mass index and diverticular disease: a 28-year follow-up study in men. AU - Rosemar,Anders, AU - Angerås,Ulf, AU - Rosengren,Annika, Y1 - 2007/12/22/ PY - 2007/04/02/received PY - 2007/09/16/accepted PY - 2007/08/10/revised PY - 2007/12/25/pubmed PY - 2008/5/30/medline PY - 2007/12/25/entrez SP - 450 EP - 5 JF - Diseases of the colon and rectum JO - Dis. Colon Rectum VL - 51 IS - 4 N2 - PURPOSE: Diverticular disease increased steadily concomitant with elevated rates of overweight and obesity during the 20th century. Therefore, the objective of this study was to investigate whether overweight and obesity in midlife predict future diverticular disease in men. METHODS: This was a prospective cohort study of a general population of men living in Göteborg, Sweden. A community-based sample of 7,494 men, investigated when aged 47 to 55 years, were followed from baseline in 1970 to 1973 for a maximum of 28 years. Hospitalization with a discharge diagnosis of diverticular disease according to the Swedish hospital discharge register was measured. RESULTS: Totally, 112 men (1.5 percent) were hospitalized with diverticular disease. A relationship between body mass index and diverticular disease was demonstrated; men with a body mass index between 20 and 22.5 kg/m2 had the lowest risk. After adjustment for covariates, the risk increased linearly in men who had a body mass index of 22.5 to 25 (multiple-adjusted hazard ratio, 2.3; 95 percent confidence interval, 0.9-6; 25-27.5 (hazard ratio, 3 (1.2-7.6)), 27.5-30 (hazard ratio 3.2, (1.2-8.6)), and 30 or greater (hazard ratio 4.4, (1.6-12.3)) kg/m2 (P for linear trend = 0.004). Men with a body mass index of < or =20 kg/m2 had a nonsignificantly elevated risk (hazard ratio, 3 (0.7-12.5)). Smoking (hazard ratio, 1.6 (1.1-2.3) and diastolic blood pressure (hazard ratio, 1.02 (1.01-1.04) per mmHg) also were independently related to risk of diverticular disease. CONCLUSIONS: In a large community-based sample of middle-aged men, overweight and obesity were strongly linked to future severe diverticular disease leading to hospitalization. SN - 0012-3706 UR - https://www.unboundmedicine.com/medline/citation/18157570/full_citation L2 - http://link.springer.com/article/10.1007/s10350-007-9172-5 DB - PRIME DP - Unbound Medicine ER -