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Alcohol consumption and the risk of age-related macular degeneration: a systematic review and meta-analysis.

Abstract

PURPOSE

To review systematically the evidence currently available on alcohol consumption and the risk of age-related macular degeneration (AMD).

DESIGN

Systematic review and meta-analysis of observational studies.

METHODS

Seven databases were searched systematically with no limits on the year or language of publication for prospective cohort studies. References identified from pertinent reviews and articles also were retrieved. Two reviewers independently searched the above databases and selected the studies using prespecified standardized criteria. These criteria included appropriate adjustment for age and smoking in the analysis. Of the 441 studies identified initially, five cohort studies met the selection criteria. Data extraction and study quality evaluation were performed independently by two reviewers and results were pooled quantitatively using meta-analytic methods.

RESULTS

The five cohort studies included 136,946 people, among whom AMD developed in 1923 (1,513 early and 410 late). Pooled results showed that heavy alcohol consumption was associated with an increased risk of early AMD (pooled odds ratio, 1.47; 95% confidence interval, 1.10 to 1.95), whereas the association between heavy alcohol consumption and risk of late AMD was inconclusive. There were insufficient data to evaluate a dose-response association between alcohol consumption and AMD or the association between moderate alcohol consumption and AMD.

CONCLUSIONS

Heavy alcohol consumption (more than three standard drinks per day) is associated with an increased risk of early AMD. Although this association seems to be independent of smoking, residual confounding effects from smoking cannot be excluded completely.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Centre for Eye Research Australia, The University of Melbourne, Victoria, Australia.

    , , ,

    Source

    American journal of ophthalmology 145:4 2008 Apr pg 707-715

    MeSH

    Alcohol Drinking
    Databases, Factual
    Humans
    Macular Degeneration
    Odds Ratio
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    18242575

    Citation

    Chong, Elaine W-T, et al. "Alcohol Consumption and the Risk of Age-related Macular Degeneration: a Systematic Review and Meta-analysis." American Journal of Ophthalmology, vol. 145, no. 4, 2008, pp. 707-715.
    Chong EW, Kreis AJ, Wong TY, et al. Alcohol consumption and the risk of age-related macular degeneration: a systematic review and meta-analysis. Am J Ophthalmol. 2008;145(4):707-715.
    Chong, E. W., Kreis, A. J., Wong, T. Y., Simpson, J. A., & Guymer, R. H. (2008). Alcohol consumption and the risk of age-related macular degeneration: a systematic review and meta-analysis. American Journal of Ophthalmology, 145(4), pp. 707-715. doi:10.1016/j.ajo.2007.12.005.
    Chong EW, et al. Alcohol Consumption and the Risk of Age-related Macular Degeneration: a Systematic Review and Meta-analysis. Am J Ophthalmol. 2008;145(4):707-715. PubMed PMID: 18242575.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol consumption and the risk of age-related macular degeneration: a systematic review and meta-analysis. AU - Chong,Elaine W-T, AU - Kreis,Andreas J, AU - Wong,Tien Y, AU - Simpson,Julie A, AU - Guymer,Robyn H, Y1 - 2008/02/01/ PY - 2007/06/10/received PY - 2007/12/03/revised PY - 2007/12/05/accepted PY - 2008/2/5/pubmed PY - 2008/5/30/medline PY - 2008/2/5/entrez SP - 707 EP - 715 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 145 IS - 4 N2 - PURPOSE: To review systematically the evidence currently available on alcohol consumption and the risk of age-related macular degeneration (AMD). DESIGN: Systematic review and meta-analysis of observational studies. METHODS: Seven databases were searched systematically with no limits on the year or language of publication for prospective cohort studies. References identified from pertinent reviews and articles also were retrieved. Two reviewers independently searched the above databases and selected the studies using prespecified standardized criteria. These criteria included appropriate adjustment for age and smoking in the analysis. Of the 441 studies identified initially, five cohort studies met the selection criteria. Data extraction and study quality evaluation were performed independently by two reviewers and results were pooled quantitatively using meta-analytic methods. RESULTS: The five cohort studies included 136,946 people, among whom AMD developed in 1923 (1,513 early and 410 late). Pooled results showed that heavy alcohol consumption was associated with an increased risk of early AMD (pooled odds ratio, 1.47; 95% confidence interval, 1.10 to 1.95), whereas the association between heavy alcohol consumption and risk of late AMD was inconclusive. There were insufficient data to evaluate a dose-response association between alcohol consumption and AMD or the association between moderate alcohol consumption and AMD. CONCLUSIONS: Heavy alcohol consumption (more than three standard drinks per day) is associated with an increased risk of early AMD. Although this association seems to be independent of smoking, residual confounding effects from smoking cannot be excluded completely. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/18242575/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(07)01013-6 DB - PRIME DP - Unbound Medicine ER -