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Italian Society of Hematology practice guidelines for the management of iron overload in thalassemia major and related disorders.
Haematologica 2008; 93(5):741-52H

Abstract

New measures of iron accumulation in liver and heart (superconducting quantum inference device and magnetic resonance imaging), and oral iron chelators (deferiprone and deferasirox) are available for managing iron overload in thalassemia major. To assure appropriate use of these new health technologies, the Italian Society of Hematology appointed a panel of experts to produce clinical practice-guidelines for the management of iron overload in thalassemia major and related disorders. The analytical hierarchy process, a technique for multicriteria decision analysis, was applied to relevant key questions in order to identify the alternative strategies, generate explicit criteria for their evaluation, and check how well the alternatives fulfilled the criteria. The result of a comprehensive systematic review of articles released from 1990 to 2007 was used as a source of scientific evidence to compare the decisional options pairwise, and select the final recommendation. Every step in the model was developed from questionnaires and group discussion. The resulting recommendations advise about which examination to carry out in order to plan iron chelation therapy, when to start iron chelation, which iron chelator to choose in regularly transfused patients, how to monitor iron chelation therapy, and when and how to switch standard therapy.

Authors+Show Affiliations

Hematology Department and BMT Unit, Cancer Center "Armando Businco", viale Edward Jenner, 09121 Cagliari, Italy. emnang@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18413891

Citation

Angelucci, Emanuele, et al. "Italian Society of Hematology Practice Guidelines for the Management of Iron Overload in Thalassemia Major and Related Disorders." Haematologica, vol. 93, no. 5, 2008, pp. 741-52.
Angelucci E, Barosi G, Camaschella C, et al. Italian Society of Hematology practice guidelines for the management of iron overload in thalassemia major and related disorders. Haematologica. 2008;93(5):741-52.
Angelucci, E., Barosi, G., Camaschella, C., Cappellini, M. D., Cazzola, M., Galanello, R., ... Tura, S. (2008). Italian Society of Hematology practice guidelines for the management of iron overload in thalassemia major and related disorders. Haematologica, 93(5), pp. 741-52. doi:10.3324/haematol.12413.
Angelucci E, et al. Italian Society of Hematology Practice Guidelines for the Management of Iron Overload in Thalassemia Major and Related Disorders. Haematologica. 2008;93(5):741-52. PubMed PMID: 18413891.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Italian Society of Hematology practice guidelines for the management of iron overload in thalassemia major and related disorders. AU - Angelucci,Emanuele, AU - Barosi,Giovanni, AU - Camaschella,Clara, AU - Cappellini,Maria Domenica, AU - Cazzola,Mario, AU - Galanello,Renzo, AU - Marchetti,Monia, AU - Piga,Antonio, AU - Tura,Sante, Y1 - 2008/04/15/ PY - 2008/4/17/pubmed PY - 2008/9/25/medline PY - 2008/4/17/entrez SP - 741 EP - 52 JF - Haematologica JO - Haematologica VL - 93 IS - 5 N2 - New measures of iron accumulation in liver and heart (superconducting quantum inference device and magnetic resonance imaging), and oral iron chelators (deferiprone and deferasirox) are available for managing iron overload in thalassemia major. To assure appropriate use of these new health technologies, the Italian Society of Hematology appointed a panel of experts to produce clinical practice-guidelines for the management of iron overload in thalassemia major and related disorders. The analytical hierarchy process, a technique for multicriteria decision analysis, was applied to relevant key questions in order to identify the alternative strategies, generate explicit criteria for their evaluation, and check how well the alternatives fulfilled the criteria. The result of a comprehensive systematic review of articles released from 1990 to 2007 was used as a source of scientific evidence to compare the decisional options pairwise, and select the final recommendation. Every step in the model was developed from questionnaires and group discussion. The resulting recommendations advise about which examination to carry out in order to plan iron chelation therapy, when to start iron chelation, which iron chelator to choose in regularly transfused patients, how to monitor iron chelation therapy, and when and how to switch standard therapy. SN - 1592-8721 UR - https://www.unboundmedicine.com/medline/citation/18413891/full_citation L2 - http://www.haematologica.org/cgi/pmidlookup?view=long&pmid=18413891 DB - PRIME DP - Unbound Medicine ER -