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Metabolic syndrome components in relation to risk of cataract extraction: a prospective cohort study of women.

Abstract

OBJECTIVE

To investigate the association between metabolic syndrome and some of its components with the incidence of cataract extraction.

DESIGN

Population-based prospective cohort study.

PARTICIPANTS

A total of 35,369 women, participating in the Swedish Mammography Cohort, aged 49 to 83 years, who completed a self-administered questionnaire about anthropometric measurements and lifestyle factors in 1997.

METHODS

The women were followed from September of 1997 to October of 2005. The cohort was matched with registers of cataract extraction in the study area.

MAIN OUTCOME MEASURES

Incident surgical extraction of age-related cataract.

RESULTS

We identified 4508 incident cases of cataract extractions during 98 months of follow-up. In multivariate analysis, women with a waist circumference >or=80 cm had an 8% increased risk of cataract extraction (rate ratio [RR], 1.08; 95% confidence interval [CI], 0.99-1.17). Women with diabetes had a 43% increased risk of cataract extraction (RR, 1.43; 95% CI, 1.10-1.86), and hypertension was associated with a 12% increased risk (RR, 1.12; 95% CI, 0.99-1.26). Women with all 3 components of the metabolic syndrome (waist >or=80 cm, diabetes, and hypertension) had a 68% increased risk of cataract extraction (RR, 1.68; 95% CI, 1.40-2.02) compared with women without any of these components. Among women aged less than 65 years at baseline with all 3 components of metabolic syndrome, the risk of cataract extraction was approximately 3-fold more (RR, 2.80; CI, 1.94-4.03).

CONCLUSIONS

Metabolic syndrome and its components, abdominal adiposity, diabetes, and hypertension, seem to be associated with an increased risk for cataract extraction, especially among women aged less than 65 years.

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  • Authors+Show Affiliations

    ,

    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. birgitta.ejdervik.lindblad@swipnet.se

    , ,

    Source

    Ophthalmology 115:10 2008 Oct pg 1687-92

    MeSH

    Abdominal Fat
    Adiposity
    Aged
    Aged, 80 and over
    Anthropometry
    Cataract
    Cataract Extraction
    Cohort Studies
    Diabetes Complications
    Female
    Follow-Up Studies
    Humans
    Hypertension
    Incidence
    Metabolic Syndrome
    Middle Aged
    Prospective Studies
    Surveys and Questionnaires
    Sweden
    Women's Health

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18538408

    Citation

    Lindblad, Birgitta Ejdervik, et al. "Metabolic Syndrome Components in Relation to Risk of Cataract Extraction: a Prospective Cohort Study of Women." Ophthalmology, vol. 115, no. 10, 2008, pp. 1687-92.
    Lindblad BE, Håkansson N, Philipson B, et al. Metabolic syndrome components in relation to risk of cataract extraction: a prospective cohort study of women. Ophthalmology. 2008;115(10):1687-92.
    Lindblad, B. E., Håkansson, N., Philipson, B., & Wolk, A. (2008). Metabolic syndrome components in relation to risk of cataract extraction: a prospective cohort study of women. Ophthalmology, 115(10), pp. 1687-92. doi:10.1016/j.ophtha.2008.04.004.
    Lindblad BE, et al. Metabolic Syndrome Components in Relation to Risk of Cataract Extraction: a Prospective Cohort Study of Women. Ophthalmology. 2008;115(10):1687-92. PubMed PMID: 18538408.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Metabolic syndrome components in relation to risk of cataract extraction: a prospective cohort study of women. AU - Lindblad,Birgitta Ejdervik, AU - Håkansson,Niclas, AU - Philipson,Bo, AU - Wolk,Alicja, Y1 - 2008/06/05/ PY - 2007/12/28/received PY - 2008/04/01/revised PY - 2008/04/03/accepted PY - 2008/6/10/pubmed PY - 2008/10/31/medline PY - 2008/6/10/entrez SP - 1687 EP - 92 JF - Ophthalmology JO - Ophthalmology VL - 115 IS - 10 N2 - OBJECTIVE: To investigate the association between metabolic syndrome and some of its components with the incidence of cataract extraction. DESIGN: Population-based prospective cohort study. PARTICIPANTS: A total of 35,369 women, participating in the Swedish Mammography Cohort, aged 49 to 83 years, who completed a self-administered questionnaire about anthropometric measurements and lifestyle factors in 1997. METHODS: The women were followed from September of 1997 to October of 2005. The cohort was matched with registers of cataract extraction in the study area. MAIN OUTCOME MEASURES: Incident surgical extraction of age-related cataract. RESULTS: We identified 4508 incident cases of cataract extractions during 98 months of follow-up. In multivariate analysis, women with a waist circumference >or=80 cm had an 8% increased risk of cataract extraction (rate ratio [RR], 1.08; 95% confidence interval [CI], 0.99-1.17). Women with diabetes had a 43% increased risk of cataract extraction (RR, 1.43; 95% CI, 1.10-1.86), and hypertension was associated with a 12% increased risk (RR, 1.12; 95% CI, 0.99-1.26). Women with all 3 components of the metabolic syndrome (waist >or=80 cm, diabetes, and hypertension) had a 68% increased risk of cataract extraction (RR, 1.68; 95% CI, 1.40-2.02) compared with women without any of these components. Among women aged less than 65 years at baseline with all 3 components of metabolic syndrome, the risk of cataract extraction was approximately 3-fold more (RR, 2.80; CI, 1.94-4.03). CONCLUSIONS: Metabolic syndrome and its components, abdominal adiposity, diabetes, and hypertension, seem to be associated with an increased risk for cataract extraction, especially among women aged less than 65 years. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/18538408/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(08)00313-8 DB - PRIME DP - Unbound Medicine ER -