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A balanced carbohydrate: protein diet in the management of Parkinson's disease.
Neurology 1991; 41(8):1295-7Neur

Abstract

Although restricting dietary protein is a proposed adjunct to treating Parkinson's disease (PD), the effect of carbohydrate consumption is unknown. We measured plasma levodopa and large neutral amino acid (LNAA) levels in nine PD patients treated with carbidopa/levodopa and different isocaloric meals containing high protein-low carbohydrate, low protein-high carbohydrate, and balanced 5:1 carbohydrate:protein mixtures. We found that levodopa levels increased significantly regardless of the type of diet, but that plasma LNAA levels varied less and motor performance was superior after the balanced diet than after the other two meals. We conclude that PD patients can consume nutritionally adequate meals and still maintain a stable plasma levodopa:LNAA ratio.

Authors+Show Affiliations

Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1866021

Citation

Berry, E M., et al. "A Balanced Carbohydrate: Protein Diet in the Management of Parkinson's Disease." Neurology, vol. 41, no. 8, 1991, pp. 1295-7.
Berry EM, Growdon JH, Wurtman JJ, et al. A balanced carbohydrate: protein diet in the management of Parkinson's disease. Neurology. 1991;41(8):1295-7.
Berry, E. M., Growdon, J. H., Wurtman, J. J., Caballero, B., & Wurtman, R. J. (1991). A balanced carbohydrate: protein diet in the management of Parkinson's disease. Neurology, 41(8), pp. 1295-7.
Berry EM, et al. A Balanced Carbohydrate: Protein Diet in the Management of Parkinson's Disease. Neurology. 1991;41(8):1295-7. PubMed PMID: 1866021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A balanced carbohydrate: protein diet in the management of Parkinson's disease. AU - Berry,E M, AU - Growdon,J H, AU - Wurtman,J J, AU - Caballero,B, AU - Wurtman,R J, PY - 1991/8/1/pubmed PY - 1991/8/1/medline PY - 1991/8/1/entrez SP - 1295 EP - 7 JF - Neurology JO - Neurology VL - 41 IS - 8 N2 - Although restricting dietary protein is a proposed adjunct to treating Parkinson's disease (PD), the effect of carbohydrate consumption is unknown. We measured plasma levodopa and large neutral amino acid (LNAA) levels in nine PD patients treated with carbidopa/levodopa and different isocaloric meals containing high protein-low carbohydrate, low protein-high carbohydrate, and balanced 5:1 carbohydrate:protein mixtures. We found that levodopa levels increased significantly regardless of the type of diet, but that plasma LNAA levels varied less and motor performance was superior after the balanced diet than after the other two meals. We conclude that PD patients can consume nutritionally adequate meals and still maintain a stable plasma levodopa:LNAA ratio. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/1866021/full_citation L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=1866021.ui DB - PRIME DP - Unbound Medicine ER -