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A balanced carbohydrate: protein diet in the management of Parkinson's disease.

Abstract

Although restricting dietary protein is a proposed adjunct to treating Parkinson's disease (PD), the effect of carbohydrate consumption is unknown. We measured plasma levodopa and large neutral amino acid (LNAA) levels in nine PD patients treated with carbidopa/levodopa and different isocaloric meals containing high protein-low carbohydrate, low protein-high carbohydrate, and balanced 5:1 carbohydrate:protein mixtures. We found that levodopa levels increased significantly regardless of the type of diet, but that plasma LNAA levels varied less and motor performance was superior after the balanced diet than after the other two meals. We conclude that PD patients can consume nutritionally adequate meals and still maintain a stable plasma levodopa:LNAA ratio.

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  • Authors+Show Affiliations

    ,

    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge.

    , , ,

    Source

    Neurology 41:8 1991 Aug pg 1295-7

    MeSH

    Amino Acids
    Dietary Carbohydrates
    Dietary Proteins
    Humans
    Levodopa
    Middle Aged
    Movement
    Parkinson Disease
    Self Concept

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    1866021

    Citation

    TY - JOUR T1 - A balanced carbohydrate: protein diet in the management of Parkinson's disease. AU - Berry,E M, AU - Growdon,J H, AU - Wurtman,J J, AU - Caballero,B, AU - Wurtman,R J, PY - 1991/8/1/pubmed PY - 1991/8/1/medline PY - 1991/8/1/entrez SP - 1295 EP - 7 JF - Neurology JO - Neurology VL - 41 IS - 8 N2 - Although restricting dietary protein is a proposed adjunct to treating Parkinson's disease (PD), the effect of carbohydrate consumption is unknown. We measured plasma levodopa and large neutral amino acid (LNAA) levels in nine PD patients treated with carbidopa/levodopa and different isocaloric meals containing high protein-low carbohydrate, low protein-high carbohydrate, and balanced 5:1 carbohydrate:protein mixtures. We found that levodopa levels increased significantly regardless of the type of diet, but that plasma LNAA levels varied less and motor performance was superior after the balanced diet than after the other two meals. We conclude that PD patients can consume nutritionally adequate meals and still maintain a stable plasma levodopa:LNAA ratio. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/1866021/full_citation L2 - http://find.galegroup.com/openurl/openurl?url_ver=Z39.88-2004&url_ctx_fmt=info:ofi/fmt:kev:mtx:ctx&req_dat=info:sid/gale:ugnid:&res_id=info:sid/gale:AONE&ctx_enc=info:ofi:enc:UTF-8&rft_val_fmt=info:ofi/fmt:kev:mtx:&rft.spage=1295&rft.volume=41&rft.issue=8&rft.issn=0028-3878&rft.date=1991 ER -