Tags

Type your tag names separated by a space and hit enter

Red ginseng for treating erectile dysfunction: a systematic review.

Abstract

AIMS

Korean red ginseng (unskinned Panax ginseng before it is steamed or otherwise heated and subsequently dried) is one of the most widely used herbal remedies. This systematic review evaluates the current evidence for the effectiveness of red ginseng for treating erectile dysfunction.

METHODS

Systematic searches were conducted on 20 electronic databases without language restrictions. Hand-searches included conference proceedings and our files. All randomized clinical studies (RCT) of red ginseng as a treatment of erectile dysfunction were considered for inclusion. Methodological quality was assessed using the Jadad score.

RESULTS

Seven RCTs met all the inclusion criteria. Their methodological quality was low on average. Six of the included RCTs compared the therapeutic efficacy of red ginseng with placebo. The meta-analysis of these data showed a significant effect (n = 349, risk ratio, 2.40; 95% CI of 1.65, 3.51, p < 0.00001, heterogeneity: tau(2) = 0.05, chi(2) = 6.42, p = 0.27, I(2) = 22%). Subgroup analyses also showed beneficial effects of red ginseng in psychogenic erectile dysfunction (n = 135, risk ratio, 2.05; 95% CI of 1.33, 3.16, p = 0.001, heterogeneity: chi(2) = 0.08, p = 0.96, I(2) = 0%).

CONCLUSIONS

Collectively these RCTs provide suggestive evidence for the effectiveness of red ginseng in the treatment of erectile dysfunction. However, the total number of RCTs included in the analysis, the total sample size and the methodological quality of the primary studies were too low to draw definitive conclusions. Thus more rigorous studies are necessary.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Korea Food Research Institute, Sungnam, South Korea.

    , , ,

    Source

    MeSH

    Adult
    Aged
    Blood Flow Velocity
    Complementary Therapies
    Dose-Response Relationship, Drug
    Erectile Dysfunction
    Humans
    Male
    Middle Aged
    Panax
    Penile Erection
    Phytotherapy
    Plant Extracts
    Randomized Controlled Trials as Topic
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    18754850

    Citation

    Jang, Dai-Ja, et al. "Red Ginseng for Treating Erectile Dysfunction: a Systematic Review." British Journal of Clinical Pharmacology, vol. 66, no. 4, 2008, pp. 444-50.
    Jang DJ, Lee MS, Shin BC, et al. Red ginseng for treating erectile dysfunction: a systematic review. Br J Clin Pharmacol. 2008;66(4):444-50.
    Jang, D. J., Lee, M. S., Shin, B. C., Lee, Y. C., & Ernst, E. (2008). Red ginseng for treating erectile dysfunction: a systematic review. British Journal of Clinical Pharmacology, 66(4), pp. 444-50. doi:10.1111/j.1365-2125.2008.03236.x.
    Jang DJ, et al. Red Ginseng for Treating Erectile Dysfunction: a Systematic Review. Br J Clin Pharmacol. 2008;66(4):444-50. PubMed PMID: 18754850.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Red ginseng for treating erectile dysfunction: a systematic review. AU - Jang,Dai-Ja, AU - Lee,Myeong Soo, AU - Shin,Byung-Cheul, AU - Lee,Young-Cheoul, AU - Ernst,Edzard, Y1 - 2008/06/09/ PY - 2008/8/30/pubmed PY - 2008/12/17/medline PY - 2008/8/30/entrez SP - 444 EP - 50 JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 66 IS - 4 N2 - AIMS: Korean red ginseng (unskinned Panax ginseng before it is steamed or otherwise heated and subsequently dried) is one of the most widely used herbal remedies. This systematic review evaluates the current evidence for the effectiveness of red ginseng for treating erectile dysfunction. METHODS: Systematic searches were conducted on 20 electronic databases without language restrictions. Hand-searches included conference proceedings and our files. All randomized clinical studies (RCT) of red ginseng as a treatment of erectile dysfunction were considered for inclusion. Methodological quality was assessed using the Jadad score. RESULTS: Seven RCTs met all the inclusion criteria. Their methodological quality was low on average. Six of the included RCTs compared the therapeutic efficacy of red ginseng with placebo. The meta-analysis of these data showed a significant effect (n = 349, risk ratio, 2.40; 95% CI of 1.65, 3.51, p < 0.00001, heterogeneity: tau(2) = 0.05, chi(2) = 6.42, p = 0.27, I(2) = 22%). Subgroup analyses also showed beneficial effects of red ginseng in psychogenic erectile dysfunction (n = 135, risk ratio, 2.05; 95% CI of 1.33, 3.16, p = 0.001, heterogeneity: chi(2) = 0.08, p = 0.96, I(2) = 0%). CONCLUSIONS: Collectively these RCTs provide suggestive evidence for the effectiveness of red ginseng in the treatment of erectile dysfunction. However, the total number of RCTs included in the analysis, the total sample size and the methodological quality of the primary studies were too low to draw definitive conclusions. Thus more rigorous studies are necessary. SN - 1365-2125 UR - https://www.unboundmedicine.com/medline/citation/18754850/full_citation L2 - https://doi.org/10.1111/j.1365-2125.2008.03236.x DB - PRIME DP - Unbound Medicine ER -