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Obesity increases the risks of diverticulitis and diverticular bleeding.

Abstract

BACKGROUND & AIMS

Studies of obesity and diverticular complications are limited. We assessed the relationship between body mass index (BMI), waist circumference, and waist-to-hip ratio and diverticulitis and diverticular bleeding.

METHODS

A prospective cohort study of 47,228 male health professionals (40-75 years old) who were free of diverticular disease in 1986 (baseline) was performed. Men reporting newly diagnosed diverticular disease on biennial follow-up questionnaires were sent supplemental questionnaires. Weight was recorded every 2 years, and data on waist and hip circumferences were collected in 1987.

RESULTS

We documented 801 incident cases of diverticulitis and 383 incident cases of diverticular bleeding during 18 years of follow-up. After adjustment for other risk factors, men with a BMI >or= 30 kg/m(2) had a relative risk (RR) of 1.78 (95% confidence interval [CI], 1.08-2.94) for diverticulitis and 3.19 (95% CI, 1.45-7.00) for diverticular bleeding compared with men with a BMI of <21 kg/m(2). Men in the highest quintile of waist circumference, compared with those in the lowest, had a multivariable RR of 1.56 (95% CI, 1.18-2.07) for diverticulitis and 1.96 (95% CI, 1.30-2.97) for diverticular bleeding. Waist-to-hip ratio was also associated with the risk of diverticular complications when the highest and lowest quintiles were compared, with a multivariable RR of 1.62 (95% CI, 1.23-2.14) for diverticulitis and 1.91 (95% CI, 1.26-2.90) for diverticular bleeding. Adjustment for BMI did not change the associations seen for waist-to-hip ratio.

CONCLUSIONS

In this large prospective cohort, BMI, waist circumference, and waist-to-hip ratio significantly increased the risks of diverticulitis and diverticular bleeding.

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  • Authors+Show Affiliations

    ,

    University of Washington School of Medicine, Seattle, Washington, USA. lisas@medicine.washington.edu

    , , ,

    Source

    Gastroenterology 136:1 2009 Jan pg 115-122.e1

    MeSH

    Adult
    Aged
    Body Mass Index
    Cohort Studies
    Diverticulitis
    Gastrointestinal Hemorrhage
    Humans
    Male
    Middle Aged
    Obesity
    Prospective Studies
    Waist Circumference
    Waist-Hip Ratio

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    18996378

    Citation

    Strate, Lisa L., et al. "Obesity Increases the Risks of Diverticulitis and Diverticular Bleeding." Gastroenterology, vol. 136, no. 1, 2009, pp. 115-122.e1.
    Strate LL, Liu YL, Aldoori WH, et al. Obesity increases the risks of diverticulitis and diverticular bleeding. Gastroenterology. 2009;136(1):115-122.e1.
    Strate, L. L., Liu, Y. L., Aldoori, W. H., Syngal, S., & Giovannucci, E. L. (2009). Obesity increases the risks of diverticulitis and diverticular bleeding. Gastroenterology, 136(1), pp. 115-122.e1. doi:10.1053/j.gastro.2008.09.025.
    Strate LL, et al. Obesity Increases the Risks of Diverticulitis and Diverticular Bleeding. Gastroenterology. 2009;136(1):115-122.e1. PubMed PMID: 18996378.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Obesity increases the risks of diverticulitis and diverticular bleeding. AU - Strate,Lisa L, AU - Liu,Yan L, AU - Aldoori,Walid H, AU - Syngal,Sapna, AU - Giovannucci,Edward L, Y1 - 2008/09/25/ PY - 2008/02/15/received PY - 2008/09/13/revised PY - 2008/09/18/accepted PY - 2008/11/11/pubmed PY - 2009/2/13/medline PY - 2008/11/11/entrez SP - 115 EP - 122.e1 JF - Gastroenterology JO - Gastroenterology VL - 136 IS - 1 N2 - BACKGROUND & AIMS: Studies of obesity and diverticular complications are limited. We assessed the relationship between body mass index (BMI), waist circumference, and waist-to-hip ratio and diverticulitis and diverticular bleeding. METHODS: A prospective cohort study of 47,228 male health professionals (40-75 years old) who were free of diverticular disease in 1986 (baseline) was performed. Men reporting newly diagnosed diverticular disease on biennial follow-up questionnaires were sent supplemental questionnaires. Weight was recorded every 2 years, and data on waist and hip circumferences were collected in 1987. RESULTS: We documented 801 incident cases of diverticulitis and 383 incident cases of diverticular bleeding during 18 years of follow-up. After adjustment for other risk factors, men with a BMI >or= 30 kg/m(2) had a relative risk (RR) of 1.78 (95% confidence interval [CI], 1.08-2.94) for diverticulitis and 3.19 (95% CI, 1.45-7.00) for diverticular bleeding compared with men with a BMI of <21 kg/m(2). Men in the highest quintile of waist circumference, compared with those in the lowest, had a multivariable RR of 1.56 (95% CI, 1.18-2.07) for diverticulitis and 1.96 (95% CI, 1.30-2.97) for diverticular bleeding. Waist-to-hip ratio was also associated with the risk of diverticular complications when the highest and lowest quintiles were compared, with a multivariable RR of 1.62 (95% CI, 1.23-2.14) for diverticulitis and 1.91 (95% CI, 1.26-2.90) for diverticular bleeding. Adjustment for BMI did not change the associations seen for waist-to-hip ratio. CONCLUSIONS: In this large prospective cohort, BMI, waist circumference, and waist-to-hip ratio significantly increased the risks of diverticulitis and diverticular bleeding. SN - 1528-0012 UR - https://www.unboundmedicine.com/medline/citation/18996378/full_citation DB - PRIME DP - Unbound Medicine ER -