Tags

Type your tag names separated by a space and hit enter

Cured meat, vegetables, and bean-curd foods in relation to childhood acute leukemia risk: a population based case-control study.

Abstract

BACKGROUND

Consumption of cured/smoked meat and fish leads to the formation of carcinogenic N-nitroso compounds in the acidic stomach. This study investigated whether consumed cured/smoked meat and fish, the major dietary resource for exposure to nitrites and nitrosamines, is associated with childhood acute leukemia.

METHODS

A population-based case-control study of Han Chinese between 2 and 20 years old was conducted in southern Taiwan. 145 acute leukemia cases and 370 age- and sex-matched controls were recruited between 1997 and 2005. Dietary data were obtained from a questionnaire. Multiple logistic regression models were used in data analyses.

RESULTS

Consumption of cured/smoked meat and fish more than once a week was associated with an increased risk of acute leukemia (OR = 1.74; 95% CI: 1.15-2.64). Conversely, higher intake of vegetables (OR = 0.55; 95% CI: 0.37-0.83) and bean-curd (OR = 0.55; 95% CI: 0.34-0.89) was associated with a reduced risk. No statistically significant association was observed between leukemia risk and the consumption of pickled vegetables, fruits, and tea.

CONCLUSION

Dietary exposure to cured/smoked meat and fish may be associated with leukemia risk through their contents of nitrites and nitrosamines among children and adolescents, and intake of vegetables and soy-bean curd may be protective.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. cliu@hsph.harvard.edu

    , , , , , , , ,

    Source

    BMC cancer 9: 2009 Jan 13 pg 15

    MeSH

    Adolescent
    Adult
    Case-Control Studies
    Child
    Child, Preschool
    China
    Diet
    Humans
    Meat
    Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Risk Factors
    Soy Foods
    Vegetables
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    19144145

    Citation

    Liu, Chen-Yu, et al. "Cured Meat, Vegetables, and Bean-curd Foods in Relation to Childhood Acute Leukemia Risk: a Population Based Case-control Study." BMC Cancer, vol. 9, 2009, p. 15.
    Liu CY, Hsu YH, Wu MT, et al. Cured meat, vegetables, and bean-curd foods in relation to childhood acute leukemia risk: a population based case-control study. BMC Cancer. 2009;9:15.
    Liu, C. Y., Hsu, Y. H., Wu, M. T., Pan, P. C., Ho, C. K., Su, L., ... Christiani, D. C. (2009). Cured meat, vegetables, and bean-curd foods in relation to childhood acute leukemia risk: a population based case-control study. BMC Cancer, 9, p. 15. doi:10.1186/1471-2407-9-15.
    Liu CY, et al. Cured Meat, Vegetables, and Bean-curd Foods in Relation to Childhood Acute Leukemia Risk: a Population Based Case-control Study. BMC Cancer. 2009 Jan 13;9:15. PubMed PMID: 19144145.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cured meat, vegetables, and bean-curd foods in relation to childhood acute leukemia risk: a population based case-control study. AU - Liu,Chen-Yu, AU - Hsu,Yi-Hsiang, AU - Wu,Ming-Tsang, AU - Pan,Pi-Chen, AU - Ho,Chi-Kung, AU - Su,Li, AU - Xu,Xin, AU - Li,Yi, AU - Christiani,David C, AU - ,, Y1 - 2009/01/13/ PY - 2008/08/05/received PY - 2009/01/13/accepted PY - 2009/1/16/entrez PY - 2009/1/16/pubmed PY - 2009/5/6/medline SP - 15 EP - 15 JF - BMC cancer JO - BMC Cancer VL - 9 N2 - BACKGROUND: Consumption of cured/smoked meat and fish leads to the formation of carcinogenic N-nitroso compounds in the acidic stomach. This study investigated whether consumed cured/smoked meat and fish, the major dietary resource for exposure to nitrites and nitrosamines, is associated with childhood acute leukemia. METHODS: A population-based case-control study of Han Chinese between 2 and 20 years old was conducted in southern Taiwan. 145 acute leukemia cases and 370 age- and sex-matched controls were recruited between 1997 and 2005. Dietary data were obtained from a questionnaire. Multiple logistic regression models were used in data analyses. RESULTS: Consumption of cured/smoked meat and fish more than once a week was associated with an increased risk of acute leukemia (OR = 1.74; 95% CI: 1.15-2.64). Conversely, higher intake of vegetables (OR = 0.55; 95% CI: 0.37-0.83) and bean-curd (OR = 0.55; 95% CI: 0.34-0.89) was associated with a reduced risk. No statistically significant association was observed between leukemia risk and the consumption of pickled vegetables, fruits, and tea. CONCLUSION: Dietary exposure to cured/smoked meat and fish may be associated with leukemia risk through their contents of nitrites and nitrosamines among children and adolescents, and intake of vegetables and soy-bean curd may be protective. SN - 1471-2407 UR - https://www.unboundmedicine.com/medline/citation/19144145/full_citation L2 - https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-9-15 DB - PRIME DP - Unbound Medicine ER -