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Cured meat, vegetables, and bean-curd foods in relation to childhood acute leukemia risk: a population based case-control study.
BMC Cancer 2009; 9:15BC

Abstract

BACKGROUND

Consumption of cured/smoked meat and fish leads to the formation of carcinogenic N-nitroso compounds in the acidic stomach. This study investigated whether consumed cured/smoked meat and fish, the major dietary resource for exposure to nitrites and nitrosamines, is associated with childhood acute leukemia.

METHODS

A population-based case-control study of Han Chinese between 2 and 20 years old was conducted in southern Taiwan. 145 acute leukemia cases and 370 age- and sex-matched controls were recruited between 1997 and 2005. Dietary data were obtained from a questionnaire. Multiple logistic regression models were used in data analyses.

RESULTS

Consumption of cured/smoked meat and fish more than once a week was associated with an increased risk of acute leukemia (OR = 1.74; 95% CI: 1.15-2.64). Conversely, higher intake of vegetables (OR = 0.55; 95% CI: 0.37-0.83) and bean-curd (OR = 0.55; 95% CI: 0.34-0.89) was associated with a reduced risk. No statistically significant association was observed between leukemia risk and the consumption of pickled vegetables, fruits, and tea.

CONCLUSION

Dietary exposure to cured/smoked meat and fish may be associated with leukemia risk through their contents of nitrites and nitrosamines among children and adolescents, and intake of vegetables and soy-bean curd may be protective.

Authors+Show Affiliations

Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. cliu@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19144145

Citation

Liu, Chen-Yu, et al. "Cured Meat, Vegetables, and Bean-curd Foods in Relation to Childhood Acute Leukemia Risk: a Population Based Case-control Study." BMC Cancer, vol. 9, 2009, p. 15.
Liu CY, Hsu YH, Wu MT, et al. Cured meat, vegetables, and bean-curd foods in relation to childhood acute leukemia risk: a population based case-control study. BMC Cancer. 2009;9:15.
Liu, C. Y., Hsu, Y. H., Wu, M. T., Pan, P. C., Ho, C. K., Su, L., ... Christiani, D. C. (2009). Cured meat, vegetables, and bean-curd foods in relation to childhood acute leukemia risk: a population based case-control study. BMC Cancer, 9, p. 15. doi:10.1186/1471-2407-9-15.
Liu CY, et al. Cured Meat, Vegetables, and Bean-curd Foods in Relation to Childhood Acute Leukemia Risk: a Population Based Case-control Study. BMC Cancer. 2009 Jan 13;9:15. PubMed PMID: 19144145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cured meat, vegetables, and bean-curd foods in relation to childhood acute leukemia risk: a population based case-control study. AU - Liu,Chen-Yu, AU - Hsu,Yi-Hsiang, AU - Wu,Ming-Tsang, AU - Pan,Pi-Chen, AU - Ho,Chi-Kung, AU - Su,Li, AU - Xu,Xin, AU - Li,Yi, AU - Christiani,David C, AU - ,, Y1 - 2009/01/13/ PY - 2008/08/05/received PY - 2009/01/13/accepted PY - 2009/1/16/entrez PY - 2009/1/16/pubmed PY - 2009/5/6/medline SP - 15 EP - 15 JF - BMC cancer JO - BMC Cancer VL - 9 N2 - BACKGROUND: Consumption of cured/smoked meat and fish leads to the formation of carcinogenic N-nitroso compounds in the acidic stomach. This study investigated whether consumed cured/smoked meat and fish, the major dietary resource for exposure to nitrites and nitrosamines, is associated with childhood acute leukemia. METHODS: A population-based case-control study of Han Chinese between 2 and 20 years old was conducted in southern Taiwan. 145 acute leukemia cases and 370 age- and sex-matched controls were recruited between 1997 and 2005. Dietary data were obtained from a questionnaire. Multiple logistic regression models were used in data analyses. RESULTS: Consumption of cured/smoked meat and fish more than once a week was associated with an increased risk of acute leukemia (OR = 1.74; 95% CI: 1.15-2.64). Conversely, higher intake of vegetables (OR = 0.55; 95% CI: 0.37-0.83) and bean-curd (OR = 0.55; 95% CI: 0.34-0.89) was associated with a reduced risk. No statistically significant association was observed between leukemia risk and the consumption of pickled vegetables, fruits, and tea. CONCLUSION: Dietary exposure to cured/smoked meat and fish may be associated with leukemia risk through their contents of nitrites and nitrosamines among children and adolescents, and intake of vegetables and soy-bean curd may be protective. SN - 1471-2407 UR - https://www.unboundmedicine.com/medline/citation/19144145/full_citation L2 - https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-9-15 DB - PRIME DP - Unbound Medicine ER -