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Family history of cancer and the risk of endometrial cancer.
Eur J Cancer Prev 2009; 18(2):95-9EJ

Abstract

To investigate the relationship between family history of cancer in first-degree relatives and the risk of endometrial cancer, we carried out a large multicentre case-control study in Italy between 1992 and 2006, including 454 endometrial cancer cases and 908 controls admitted in hospital for acute, non-neoplastic diseases. Conditional logistic regression was used to estimate odds ratios (ORs) and corresponding 95% confidence intervals (CI). Relative to women with no family history of uterine cancer, the ORs were 2.1 (95% CI: 0.7-6.4) for those reporting a family history of endometrial cancer and 1.8 (95% CI: 1.0-3.2) for a family history of any uterine cancer. A family history of intestinal cancer was directly associated with endometrial cancer risk (OR=1.6; 95% CI: 1.0-2.7). Direct associations were found for a few other cancer sites. In conclusion, a family history of endometrial, uterine or intestinal cancer in first-degree relatives is associated with an increased risk of endometrial cancer.

Authors+Show Affiliations

Mario Negri Institute for Pharmacological Research, Via Giuseppe La Masa 19, Milan, Italy. lucenteforte@marionegri.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19337055

Citation

Lucenteforte, Ersilia, et al. "Family History of Cancer and the Risk of Endometrial Cancer." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 18, no. 2, 2009, pp. 95-9.
Lucenteforte E, Talamini R, Montella M, et al. Family history of cancer and the risk of endometrial cancer. Eur J Cancer Prev. 2009;18(2):95-9.
Lucenteforte, E., Talamini, R., Montella, M., Dal Maso, L., Pelucchi, C., Franceschi, S., ... Negri, E. (2009). Family history of cancer and the risk of endometrial cancer. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 18(2), pp. 95-9. doi:10.1097/CEJ.0b013e328305a0c9.
Lucenteforte E, et al. Family History of Cancer and the Risk of Endometrial Cancer. Eur J Cancer Prev. 2009;18(2):95-9. PubMed PMID: 19337055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Family history of cancer and the risk of endometrial cancer. AU - Lucenteforte,Ersilia, AU - Talamini,Renato, AU - Montella,Maurizio, AU - Dal Maso,Luigino, AU - Pelucchi,Claudio, AU - Franceschi,Silvia, AU - La Vecchia,Carlo, AU - Negri,Eva, PY - 2009/4/2/entrez PY - 2009/4/2/pubmed PY - 2009/7/28/medline SP - 95 EP - 9 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 18 IS - 2 N2 - To investigate the relationship between family history of cancer in first-degree relatives and the risk of endometrial cancer, we carried out a large multicentre case-control study in Italy between 1992 and 2006, including 454 endometrial cancer cases and 908 controls admitted in hospital for acute, non-neoplastic diseases. Conditional logistic regression was used to estimate odds ratios (ORs) and corresponding 95% confidence intervals (CI). Relative to women with no family history of uterine cancer, the ORs were 2.1 (95% CI: 0.7-6.4) for those reporting a family history of endometrial cancer and 1.8 (95% CI: 1.0-3.2) for a family history of any uterine cancer. A family history of intestinal cancer was directly associated with endometrial cancer risk (OR=1.6; 95% CI: 1.0-2.7). Direct associations were found for a few other cancer sites. In conclusion, a family history of endometrial, uterine or intestinal cancer in first-degree relatives is associated with an increased risk of endometrial cancer. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/19337055/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=19337055 DB - PRIME DP - Unbound Medicine ER -