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Family history of cancer and the risk of endometrial cancer.

Abstract

To investigate the relationship between family history of cancer in first-degree relatives and the risk of endometrial cancer, we carried out a large multicentre case-control study in Italy between 1992 and 2006, including 454 endometrial cancer cases and 908 controls admitted in hospital for acute, non-neoplastic diseases. Conditional logistic regression was used to estimate odds ratios (ORs) and corresponding 95% confidence intervals (CI). Relative to women with no family history of uterine cancer, the ORs were 2.1 (95% CI: 0.7-6.4) for those reporting a family history of endometrial cancer and 1.8 (95% CI: 1.0-3.2) for a family history of any uterine cancer. A family history of intestinal cancer was directly associated with endometrial cancer risk (OR=1.6; 95% CI: 1.0-2.7). Direct associations were found for a few other cancer sites. In conclusion, a family history of endometrial, uterine or intestinal cancer in first-degree relatives is associated with an increased risk of endometrial cancer.

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  • Authors+Show Affiliations

    ,

    Mario Negri Institute for Pharmacological Research, Via Giuseppe La Masa 19, Milan, Italy. lucenteforte@marionegri.it

    , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Carcinoma
    Case-Control Studies
    Endometrial Neoplasms
    Family Health
    Female
    Humans
    Middle Aged
    Neoplasms
    Risk Factors
    Young Adult

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19337055

    Citation

    Lucenteforte, Ersilia, et al. "Family History of Cancer and the Risk of Endometrial Cancer." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 18, no. 2, 2009, pp. 95-9.
    Lucenteforte E, Talamini R, Montella M, et al. Family history of cancer and the risk of endometrial cancer. Eur J Cancer Prev. 2009;18(2):95-9.
    Lucenteforte, E., Talamini, R., Montella, M., Dal Maso, L., Pelucchi, C., Franceschi, S., ... Negri, E. (2009). Family history of cancer and the risk of endometrial cancer. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 18(2), pp. 95-9. doi:10.1097/CEJ.0b013e328305a0c9.
    Lucenteforte E, et al. Family History of Cancer and the Risk of Endometrial Cancer. Eur J Cancer Prev. 2009;18(2):95-9. PubMed PMID: 19337055.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Family history of cancer and the risk of endometrial cancer. AU - Lucenteforte,Ersilia, AU - Talamini,Renato, AU - Montella,Maurizio, AU - Dal Maso,Luigino, AU - Pelucchi,Claudio, AU - Franceschi,Silvia, AU - La Vecchia,Carlo, AU - Negri,Eva, PY - 2009/4/2/entrez PY - 2009/4/2/pubmed PY - 2009/7/28/medline SP - 95 EP - 9 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 18 IS - 2 N2 - To investigate the relationship between family history of cancer in first-degree relatives and the risk of endometrial cancer, we carried out a large multicentre case-control study in Italy between 1992 and 2006, including 454 endometrial cancer cases and 908 controls admitted in hospital for acute, non-neoplastic diseases. Conditional logistic regression was used to estimate odds ratios (ORs) and corresponding 95% confidence intervals (CI). Relative to women with no family history of uterine cancer, the ORs were 2.1 (95% CI: 0.7-6.4) for those reporting a family history of endometrial cancer and 1.8 (95% CI: 1.0-3.2) for a family history of any uterine cancer. A family history of intestinal cancer was directly associated with endometrial cancer risk (OR=1.6; 95% CI: 1.0-2.7). Direct associations were found for a few other cancer sites. In conclusion, a family history of endometrial, uterine or intestinal cancer in first-degree relatives is associated with an increased risk of endometrial cancer. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/19337055/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=19337055 DB - PRIME DP - Unbound Medicine ER -