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Adolescent manifestations of metabolic syndrome among children born to women with gestational diabetes in a general-population birth cohort.

Abstract

The association between maternal gestational diabetes (GDM) and manifestations of metabolic syndrome among Caucasian adolescents was studied with data from the population-based Northern Finland 1986 Birth Cohort. This is a longitudinal cohort study from early pregnancy until offspring age 16 years and includes data from a risk group-based GDM screen of pregnant mothers by an oral glucose tolerance test. Metabolic outcomes were compared between the offspring of women with GDM (OGDM; n = 95) and reference group offspring (n = 3,909). The prevalence of overweight was significantly higher in the OGDM group (18.8 vs. 8.4%; P < 0.001) than in the reference group. The median body mass index (20.8 vs. 20.2 kg/m(2), 95% confidence interval (CI) for the percentage difference adjusted for sex: 3.5%, 9.5%), waist circumference (73.3 vs. 71.5 cm, 95% CI: 3.2%, 7.5%), and fasting insulin (10.20 vs. 9.30 milliunits/L, 95% CI: 5.9%, 26.0%) were higher, and homeostatic model assessment-insulin sensitivity (74.7 vs. 82.3, 95% CI: -20.6%, -5.4%) was lower in the OGDM group. These differences were similar after an additional adjustment for birth weight and gestational age. The differences in waist circumference, insulin, and homeostatic model assessment-insulin sensitivity were attenuated but remained statistically significant after additional adjustment for body mass index at 16 years. These findings highlight the importance of prevention strategies among children born to women with GDM.

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  • Authors+Show Affiliations

    ,

    Department of Clinical Sciences/Obstetrics and Gynecology, Oulu University Hospital and University of Oulu, Oulu, Finland.

    , , , , , , ,

    Source

    American journal of epidemiology 169:10 2009 May 15 pg 1209-15

    MeSH

    Adolescent
    Birth Weight
    Cohort Studies
    Confidence Intervals
    Diabetes, Gestational
    Female
    Finland
    Glucose Tolerance Test
    Humans
    Linear Models
    Male
    Metabolic Syndrome
    Multivariate Analysis
    Phenotype
    Pregnancy
    Prospective Studies
    Risk Factors

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19363101

    Citation

    Vääräsmäki, Marja, et al. "Adolescent Manifestations of Metabolic Syndrome Among Children Born to Women With Gestational Diabetes in a General-population Birth Cohort." American Journal of Epidemiology, vol. 169, no. 10, 2009, pp. 1209-15.
    Vääräsmäki M, Pouta A, Elliot P, et al. Adolescent manifestations of metabolic syndrome among children born to women with gestational diabetes in a general-population birth cohort. Am J Epidemiol. 2009;169(10):1209-15.
    Vääräsmäki, M., Pouta, A., Elliot, P., Tapanainen, P., Sovio, U., Ruokonen, A., ... Järvelin, M. R. (2009). Adolescent manifestations of metabolic syndrome among children born to women with gestational diabetes in a general-population birth cohort. American Journal of Epidemiology, 169(10), pp. 1209-15. doi:10.1093/aje/kwp020.
    Vääräsmäki M, et al. Adolescent Manifestations of Metabolic Syndrome Among Children Born to Women With Gestational Diabetes in a General-population Birth Cohort. Am J Epidemiol. 2009 May 15;169(10):1209-15. PubMed PMID: 19363101.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Adolescent manifestations of metabolic syndrome among children born to women with gestational diabetes in a general-population birth cohort. AU - Vääräsmäki,Marja, AU - Pouta,Anneli, AU - Elliot,Paul, AU - Tapanainen,Päivi, AU - Sovio,Ulla, AU - Ruokonen,Aimo, AU - Hartikainen,Anna-Liisa, AU - McCarthy,Mark, AU - Järvelin,Marjo-Riitta, Y1 - 2009/04/10/ PY - 2009/4/14/entrez PY - 2009/4/14/pubmed PY - 2009/6/9/medline SP - 1209 EP - 15 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 169 IS - 10 N2 - The association between maternal gestational diabetes (GDM) and manifestations of metabolic syndrome among Caucasian adolescents was studied with data from the population-based Northern Finland 1986 Birth Cohort. This is a longitudinal cohort study from early pregnancy until offspring age 16 years and includes data from a risk group-based GDM screen of pregnant mothers by an oral glucose tolerance test. Metabolic outcomes were compared between the offspring of women with GDM (OGDM; n = 95) and reference group offspring (n = 3,909). The prevalence of overweight was significantly higher in the OGDM group (18.8 vs. 8.4%; P < 0.001) than in the reference group. The median body mass index (20.8 vs. 20.2 kg/m(2), 95% confidence interval (CI) for the percentage difference adjusted for sex: 3.5%, 9.5%), waist circumference (73.3 vs. 71.5 cm, 95% CI: 3.2%, 7.5%), and fasting insulin (10.20 vs. 9.30 milliunits/L, 95% CI: 5.9%, 26.0%) were higher, and homeostatic model assessment-insulin sensitivity (74.7 vs. 82.3, 95% CI: -20.6%, -5.4%) was lower in the OGDM group. These differences were similar after an additional adjustment for birth weight and gestational age. The differences in waist circumference, insulin, and homeostatic model assessment-insulin sensitivity were attenuated but remained statistically significant after additional adjustment for body mass index at 16 years. These findings highlight the importance of prevention strategies among children born to women with GDM. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/19363101/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwp020 DB - PRIME DP - Unbound Medicine ER -