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Physical activity decreases diverticular complications.

Abstract

OBJECTIVES

Little is known about the effect of physical activity on diverticular complications. This study prospectively examined the associations between physical activity and diverticular bleeding and diverticulitis.

METHODS

We studied 47,228 US males in the Health Professionals Follow-up Study cohort who were aged 40-75 years and free of diverticular disease, gastrointestinal cancer, and inflammatory bowel disease at baseline in 1986. Men reporting newly diagnosed diverticular disease on biennial follow-up questionnaires were sent supplemental questionnaires outlining details of diagnosis and treatment. Physical activity was assessed every 2 years. Men recorded the average time per week spent in eight recreational activities, and flights of stairs climbed per day. Cox proportional hazards regression was used to calculate relative risks (RRs).

RESULTS

During 18 years of follow-up, 800 cases of diverticulitis and 383 cases of diverticular bleeding were identified. Total cumulative physical activity was associated with a decreased risk of diverticulitis and diverticular bleeding. After adjustment for potential confounders, the RR for men in the highest quintile of total activity (> or = 57.4 metabolic equivalent hours per week (MET-h/week) was 0.75 (95% confidence interval, CI, 0.58-0.95) for diverticulitis and 0.54 (95% CI, 0.38-0.77) for bleeding, as compared with men in the lowest quintile (< or = 8.2 MET-h/week). Vigorous activity was inversely related to diverticulitis in a high vs. low comparison (multivariable RR, 0.66; 95% CI, 0.51-0.86) and bleeding (multivariable RR, 0.61; 95% CI, 0.41-0.90), whereas nonvigorous activity was not. These results were similar for recent (simple updated) and baseline activity.

CONCLUSIONS

Data from this large prospective cohort suggest that physical activity lowers the risk of diverticulitis and diverticular bleeding. Vigorous activity appears to account for this association.

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  • Authors+Show Affiliations

    ,

    Division of Gastroenterology, Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98104, USA. lisas@medicine.washington.edu

    , ,

    Source

    MeSH

    Adult
    Aged
    Cohort Studies
    Diverticulitis, Colonic
    Diverticulum, Colon
    Exercise
    Follow-Up Studies
    Gastrointestinal Hemorrhage
    Humans
    Incidence
    Life Style
    Male
    Middle Aged
    Motor Activity
    Multivariate Analysis
    Physical Fitness
    Proportional Hazards Models
    Reference Values
    Risk Assessment
    Severity of Illness Index

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    19367267

    Citation

    Strate, Lisa L., et al. "Physical Activity Decreases Diverticular Complications." The American Journal of Gastroenterology, vol. 104, no. 5, 2009, pp. 1221-30.
    Strate LL, Liu YL, Aldoori WH, et al. Physical activity decreases diverticular complications. Am J Gastroenterol. 2009;104(5):1221-30.
    Strate, L. L., Liu, Y. L., Aldoori, W. H., & Giovannucci, E. L. (2009). Physical activity decreases diverticular complications. The American Journal of Gastroenterology, 104(5), pp. 1221-30. doi:10.1038/ajg.2009.121.
    Strate LL, et al. Physical Activity Decreases Diverticular Complications. Am J Gastroenterol. 2009;104(5):1221-30. PubMed PMID: 19367267.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Physical activity decreases diverticular complications. AU - Strate,Lisa L, AU - Liu,Yan L, AU - Aldoori,Walid H, AU - Giovannucci,Edward L, Y1 - 2009/04/14/ PY - 2009/4/16/entrez PY - 2009/4/16/pubmed PY - 2009/6/16/medline SP - 1221 EP - 30 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 104 IS - 5 N2 - OBJECTIVES: Little is known about the effect of physical activity on diverticular complications. This study prospectively examined the associations between physical activity and diverticular bleeding and diverticulitis. METHODS: We studied 47,228 US males in the Health Professionals Follow-up Study cohort who were aged 40-75 years and free of diverticular disease, gastrointestinal cancer, and inflammatory bowel disease at baseline in 1986. Men reporting newly diagnosed diverticular disease on biennial follow-up questionnaires were sent supplemental questionnaires outlining details of diagnosis and treatment. Physical activity was assessed every 2 years. Men recorded the average time per week spent in eight recreational activities, and flights of stairs climbed per day. Cox proportional hazards regression was used to calculate relative risks (RRs). RESULTS: During 18 years of follow-up, 800 cases of diverticulitis and 383 cases of diverticular bleeding were identified. Total cumulative physical activity was associated with a decreased risk of diverticulitis and diverticular bleeding. After adjustment for potential confounders, the RR for men in the highest quintile of total activity (> or = 57.4 metabolic equivalent hours per week (MET-h/week) was 0.75 (95% confidence interval, CI, 0.58-0.95) for diverticulitis and 0.54 (95% CI, 0.38-0.77) for bleeding, as compared with men in the lowest quintile (< or = 8.2 MET-h/week). Vigorous activity was inversely related to diverticulitis in a high vs. low comparison (multivariable RR, 0.66; 95% CI, 0.51-0.86) and bleeding (multivariable RR, 0.61; 95% CI, 0.41-0.90), whereas nonvigorous activity was not. These results were similar for recent (simple updated) and baseline activity. CONCLUSIONS: Data from this large prospective cohort suggest that physical activity lowers the risk of diverticulitis and diverticular bleeding. Vigorous activity appears to account for this association. SN - 1572-0241 UR - https://www.unboundmedicine.com/medline/citation/19367267/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=19367267 DB - PRIME DP - Unbound Medicine ER -