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The association between birthweight 4000 g or greater and perinatal outcomes in patients with and without gestational diabetes mellitus.
Am J Obstet Gynecol. 2009 Jun; 200(6):672.e1-4.AJ

Abstract

OBJECTIVE

The objective of the study was to examine the association between birthweight of 4000 g or greater and perinatal outcomes in women with and without gestational diabetes mellitus (GDM).

STUDY DESIGN

This was a retrospective cohort study of 36,241 singleton pregnancies stratified by the diagnosis of GDM, with presence or absence of birthweight of 4000 g or greater. Outcomes examined included neonatal hyperbilirubinemia, hypoglycemia, respiratory distress syndrome (RDS), shoulder dystocia, and Erb's palsy. chi(2) tests and multivariable logistic regression analyses were used to control for confounders.

RESULTS

In women with GDM, neonates with a birthweight of 4000 g or greater, compared with those with a birthweight of less than 4000 g, had higher frequencies of hypoglycemia (5.3% vs 2.6%; P = .04), RDS (4.0% vs 1.5%; P = .03), shoulder dystocia (10.5% vs 1.6%; P < .001), and Erb's palsy (2.6% vs 0.2%; P < .001). Even without GDM, these outcomes occurred more frequently in infants with birthweight of 4000 g or greater. GDM increases the odds of adverse outcomes associated with birthweight of 4000 g or greater, particularly shoulder dystocia (adjusted odds ratios [aORs], 16.4 [GDM] vs 9.6 [non-GDM] and Erb's palsy (aORs, 41.9 [GDM] vs 6.7 [non-GDM]).

CONCLUSION

Birthweight of 4000 g or greater is associated with a higher incidence of adverse perinatal outcomes such that neonatal providers should be alerted.

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Authors+Show Affiliations

Esakoff TF
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, School of Medicine, San Francisco, CA, USA.
Cheng YW
No affiliation info available
Sparks TN
No affiliation info available
Caughey AB
No affiliation info available

MeSH

Birth WeightCohort StudiesDiabetes, GestationalFemaleFetal MacrosomiaHumansPregnancyPregnancy OutcomeRetrospective Studies

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19376489

Citation

Esakoff, Tania F., et al. "The Association Between Birthweight 4000 G or Greater and Perinatal Outcomes in Patients With and Without Gestational Diabetes Mellitus." American Journal of Obstetrics and Gynecology, vol. 200, no. 6, 2009, pp. 672.e1-4.
Esakoff TF, Cheng YW, Sparks TN, et al. The association between birthweight 4000 g or greater and perinatal outcomes in patients with and without gestational diabetes mellitus. Am J Obstet Gynecol. 2009;200(6):672.e1-4.
Esakoff, T. F., Cheng, Y. W., Sparks, T. N., & Caughey, A. B. (2009). The association between birthweight 4000 g or greater and perinatal outcomes in patients with and without gestational diabetes mellitus. American Journal of Obstetrics and Gynecology, 200(6), e1-4. https://doi.org/10.1016/j.ajog.2009.02.035
Esakoff TF, et al. The Association Between Birthweight 4000 G or Greater and Perinatal Outcomes in Patients With and Without Gestational Diabetes Mellitus. Am J Obstet Gynecol. 2009;200(6):672.e1-4. PubMed PMID: 19376489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between birthweight 4000 g or greater and perinatal outcomes in patients with and without gestational diabetes mellitus. AU - Esakoff,Tania F, AU - Cheng,Yvonne W, AU - Sparks,Teresa N, AU - Caughey,Aaron B, Y1 - 2009/04/18/ PY - 2008/09/15/received PY - 2008/12/12/revised PY - 2009/02/26/accepted PY - 2009/4/21/entrez PY - 2009/4/21/pubmed PY - 2009/7/2/medline SP - 672.e1 EP - 4 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 200 IS - 6 N2 - OBJECTIVE: The objective of the study was to examine the association between birthweight of 4000 g or greater and perinatal outcomes in women with and without gestational diabetes mellitus (GDM). STUDY DESIGN: This was a retrospective cohort study of 36,241 singleton pregnancies stratified by the diagnosis of GDM, with presence or absence of birthweight of 4000 g or greater. Outcomes examined included neonatal hyperbilirubinemia, hypoglycemia, respiratory distress syndrome (RDS), shoulder dystocia, and Erb's palsy. chi(2) tests and multivariable logistic regression analyses were used to control for confounders. RESULTS: In women with GDM, neonates with a birthweight of 4000 g or greater, compared with those with a birthweight of less than 4000 g, had higher frequencies of hypoglycemia (5.3% vs 2.6%; P = .04), RDS (4.0% vs 1.5%; P = .03), shoulder dystocia (10.5% vs 1.6%; P < .001), and Erb's palsy (2.6% vs 0.2%; P < .001). Even without GDM, these outcomes occurred more frequently in infants with birthweight of 4000 g or greater. GDM increases the odds of adverse outcomes associated with birthweight of 4000 g or greater, particularly shoulder dystocia (adjusted odds ratios [aORs], 16.4 [GDM] vs 9.6 [non-GDM] and Erb's palsy (aORs, 41.9 [GDM] vs 6.7 [non-GDM]). CONCLUSION: Birthweight of 4000 g or greater is associated with a higher incidence of adverse perinatal outcomes such that neonatal providers should be alerted. SN - 1097-6868 UR - https://www.unboundmedicine.com/medline/citation/19376489/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9378(09)00226-9 DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓75]

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