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Nutritional factors in the pathogenesis of ear disease in children: a systematic review.
Ann Trop Paediatr 2009; 29(2):85-99AT

Abstract

BACKGROUND

Ear disease is a major health problem in poorly resourced countries. The role of nutritional deficiencies in its pathogenesis and in relation to chronic suppurative otitis media (CSOM) has not been reviewed previously.

METHODS

A systematic review was undertaken using Pubmed, SCOPUS, Cinahl on Ovid, the Cochrane Database and selected medical journals, with no language restriction. Nutritional mechanisms potentially related to ear disease and CSOM risks were reviewed. All studies (observational, case-control, cohort and clinical trials including randomised controlled trials) with nutrition-related information were included. The titles and/or abstracts of all retrieved studies were reviewed and full articles were obtained for relevant studies. Exclusion criteria were multiple publication or studies which did not report nutritional information.

RESULTS

Supplementation studies using single micronutrients and vitamins to determine efficacy in reducing acute or chronic otitis media provided some evidence for an association of middle-ear pathology with deficiencies of zinc or vitamin A. Multi-micronutrient supplementation studies provided further support for a beneficial effect, although the number of studies was small and they were heterogeneous and uncontrolled. No human study was identified which specifically examined the association between copper, selenium or vitamin D status and middle-ear disease or infection.

CONCLUSION

Particularly in developing countries, research on micronutrient status and vitamin deficiency and their influence on middle-ear disease is required to improve knowledge of the pathogenesis of middle-ear infection and to determine the relevance of nutritional interventions in prevention and treatment.

Authors+Show Affiliations

WHO Collaborating Centre on Hearing Impairment, Child & Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

19460262

Citation

Elemraid, M A., et al. "Nutritional Factors in the Pathogenesis of Ear Disease in Children: a Systematic Review." Annals of Tropical Paediatrics, vol. 29, no. 2, 2009, pp. 85-99.
Elemraid MA, Mackenzie IJ, Fraser WD, et al. Nutritional factors in the pathogenesis of ear disease in children: a systematic review. Ann Trop Paediatr. 2009;29(2):85-99.
Elemraid, M. A., Mackenzie, I. J., Fraser, W. D., & Brabin, B. J. (2009). Nutritional factors in the pathogenesis of ear disease in children: a systematic review. Annals of Tropical Paediatrics, 29(2), pp. 85-99. doi:10.1179/146532809X440707.
Elemraid MA, et al. Nutritional Factors in the Pathogenesis of Ear Disease in Children: a Systematic Review. Ann Trop Paediatr. 2009;29(2):85-99. PubMed PMID: 19460262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional factors in the pathogenesis of ear disease in children: a systematic review. AU - Elemraid,M A, AU - Mackenzie,I J, AU - Fraser,W D, AU - Brabin,B J, PY - 2009/5/23/entrez PY - 2009/5/23/pubmed PY - 2009/7/18/medline SP - 85 EP - 99 JF - Annals of tropical paediatrics JO - Ann Trop Paediatr VL - 29 IS - 2 N2 - BACKGROUND: Ear disease is a major health problem in poorly resourced countries. The role of nutritional deficiencies in its pathogenesis and in relation to chronic suppurative otitis media (CSOM) has not been reviewed previously. METHODS: A systematic review was undertaken using Pubmed, SCOPUS, Cinahl on Ovid, the Cochrane Database and selected medical journals, with no language restriction. Nutritional mechanisms potentially related to ear disease and CSOM risks were reviewed. All studies (observational, case-control, cohort and clinical trials including randomised controlled trials) with nutrition-related information were included. The titles and/or abstracts of all retrieved studies were reviewed and full articles were obtained for relevant studies. Exclusion criteria were multiple publication or studies which did not report nutritional information. RESULTS: Supplementation studies using single micronutrients and vitamins to determine efficacy in reducing acute or chronic otitis media provided some evidence for an association of middle-ear pathology with deficiencies of zinc or vitamin A. Multi-micronutrient supplementation studies provided further support for a beneficial effect, although the number of studies was small and they were heterogeneous and uncontrolled. No human study was identified which specifically examined the association between copper, selenium or vitamin D status and middle-ear disease or infection. CONCLUSION: Particularly in developing countries, research on micronutrient status and vitamin deficiency and their influence on middle-ear disease is required to improve knowledge of the pathogenesis of middle-ear infection and to determine the relevance of nutritional interventions in prevention and treatment. SN - 1465-3281 UR - https://www.unboundmedicine.com/medline/citation/19460262/full_citation L2 - https://medlineplus.gov/nutrition.html DB - PRIME DP - Unbound Medicine ER -