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Alcohol consumption as a risk factor for dementia and cognitive decline: meta-analysis of prospective studies.
Am J Geriatr Psychiatry 2009; 17(7):542-55AJ

Abstract

The relationships between alcohol consumption and dementia and cognitive decline were investigated in a systematic review including meta-analyses of 15 prospective studies. Follow-ups ranged from 2 to 8 years. Meta-analyses were conducted on samples including 14,646 participants evaluated for Alzheimer disease (AD), 10,225 participants evaluated for vascular dementia (VaD), and 11,875 followed for any type of dementia (Any dementia). The pooled relative risks (RRs) of AD, VaD, and Any dementia for light to moderate drinkers compared with nondrinkers were 0.72 (95% CI = 0.61-0.86), 0.75 (95% CI = 0.57-0.98), and 0.74 (95% CI = 0.61-0.91), respectively. When the more generally classified "drinkers," were compared with "nondrinkers," they had a reduced risk of AD (RR = 0.66, 95% CI = 0.47-0.94) and Any dementia (RR = 0.53, 95% CI = 0.53-0.82) but not cognitive decline. There were not enough data to examine VaD risk among "drinkers." Those classified as heavy drinkers did not have an increased risk of Any dementia compared with nondrinkers, but this may reflect sampling bias. Our results suggest that alcohol drinkers in late life have reduced risk of dementia. It is unclear whether this reflects selection effects in cohort studies commencing in late life, a protective effect of alcohol consumption throughout adulthood, or a specific benefit of alcohol in late life.

Authors+Show Affiliations

Centre for Mental Health Research, Australian National University, Canberra, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

19546653

Citation

Anstey, Kaarin J., et al. "Alcohol Consumption as a Risk Factor for Dementia and Cognitive Decline: Meta-analysis of Prospective Studies." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, vol. 17, no. 7, 2009, pp. 542-55.
Anstey KJ, Mack HA, Cherbuin N. Alcohol consumption as a risk factor for dementia and cognitive decline: meta-analysis of prospective studies. Am J Geriatr Psychiatry. 2009;17(7):542-55.
Anstey, K. J., Mack, H. A., & Cherbuin, N. (2009). Alcohol consumption as a risk factor for dementia and cognitive decline: meta-analysis of prospective studies. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, 17(7), pp. 542-55. doi:10.1097/JGP.0b013e3181a2fd07.
Anstey KJ, Mack HA, Cherbuin N. Alcohol Consumption as a Risk Factor for Dementia and Cognitive Decline: Meta-analysis of Prospective Studies. Am J Geriatr Psychiatry. 2009;17(7):542-55. PubMed PMID: 19546653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption as a risk factor for dementia and cognitive decline: meta-analysis of prospective studies. AU - Anstey,Kaarin J, AU - Mack,Holly A, AU - Cherbuin,Nicolas, PY - 2009/6/24/entrez PY - 2009/6/24/pubmed PY - 2009/9/24/medline SP - 542 EP - 55 JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry JO - Am J Geriatr Psychiatry VL - 17 IS - 7 N2 - The relationships between alcohol consumption and dementia and cognitive decline were investigated in a systematic review including meta-analyses of 15 prospective studies. Follow-ups ranged from 2 to 8 years. Meta-analyses were conducted on samples including 14,646 participants evaluated for Alzheimer disease (AD), 10,225 participants evaluated for vascular dementia (VaD), and 11,875 followed for any type of dementia (Any dementia). The pooled relative risks (RRs) of AD, VaD, and Any dementia for light to moderate drinkers compared with nondrinkers were 0.72 (95% CI = 0.61-0.86), 0.75 (95% CI = 0.57-0.98), and 0.74 (95% CI = 0.61-0.91), respectively. When the more generally classified "drinkers," were compared with "nondrinkers," they had a reduced risk of AD (RR = 0.66, 95% CI = 0.47-0.94) and Any dementia (RR = 0.53, 95% CI = 0.53-0.82) but not cognitive decline. There were not enough data to examine VaD risk among "drinkers." Those classified as heavy drinkers did not have an increased risk of Any dementia compared with nondrinkers, but this may reflect sampling bias. Our results suggest that alcohol drinkers in late life have reduced risk of dementia. It is unclear whether this reflects selection effects in cohort studies commencing in late life, a protective effect of alcohol consumption throughout adulthood, or a specific benefit of alcohol in late life. SN - 1545-7214 UR - https://www.unboundmedicine.com/medline/citation/19546653/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/00019442-200907000-00003 DB - PRIME DP - Unbound Medicine ER -