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Abnormal pain modulation in patients with spatially distributed chronic pain: fibromyalgia.

Abstract

Many chronic pain syndromes are associated with hypersensitivity to painful stimuli and with reduced endogenous pain inhibition. These findings suggest that modulation of pain-related information may be linked to the onset or maintenance of chronic pain. The combination of heightened pain sensitivity and reduced pain inhibition seems to predispose individuals to greater risk for increased acute clinical pain. It is unknown whether such pain processing abnormalities may also place individuals at increased risk for chronic pain. Psychophysical methods can be used for the evaluation of pain sensitivity and pain inhibition. Long-term prospective studies that could yield insight into the role of heightened pain sensitivity and pain disinhibition for the development of chronic pain disorders like fibromyalgia in the general population are lacking, however.

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  • Authors+Show Affiliations

    Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610-0221, USA. staudr@ufl.edu

    Source

    MeSH

    Animals
    Chronic Disease
    Fibromyalgia
    Humans
    Pain
    Pain Threshold

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    19647141

    Citation

    Staud, Roland. "Abnormal Pain Modulation in Patients With Spatially Distributed Chronic Pain: Fibromyalgia." Rheumatic Diseases Clinics of North America, vol. 35, no. 2, 2009, pp. 263-74.
    Staud R. Abnormal pain modulation in patients with spatially distributed chronic pain: fibromyalgia. Rheum Dis Clin North Am. 2009;35(2):263-74.
    Staud, R. (2009). Abnormal pain modulation in patients with spatially distributed chronic pain: fibromyalgia. Rheumatic Diseases Clinics of North America, 35(2), pp. 263-74. doi:10.1016/j.rdc.2009.05.006.
    Staud R. Abnormal Pain Modulation in Patients With Spatially Distributed Chronic Pain: Fibromyalgia. Rheum Dis Clin North Am. 2009;35(2):263-74. PubMed PMID: 19647141.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Abnormal pain modulation in patients with spatially distributed chronic pain: fibromyalgia. A1 - Staud,Roland, PY - 2009/8/4/entrez PY - 2009/8/4/pubmed PY - 2009/10/22/medline SP - 263 EP - 74 JF - Rheumatic diseases clinics of North America JO - Rheum. Dis. Clin. North Am. VL - 35 IS - 2 N2 - Many chronic pain syndromes are associated with hypersensitivity to painful stimuli and with reduced endogenous pain inhibition. These findings suggest that modulation of pain-related information may be linked to the onset or maintenance of chronic pain. The combination of heightened pain sensitivity and reduced pain inhibition seems to predispose individuals to greater risk for increased acute clinical pain. It is unknown whether such pain processing abnormalities may also place individuals at increased risk for chronic pain. Psychophysical methods can be used for the evaluation of pain sensitivity and pain inhibition. Long-term prospective studies that could yield insight into the role of heightened pain sensitivity and pain disinhibition for the development of chronic pain disorders like fibromyalgia in the general population are lacking, however. SN - 1558-3163 UR - https://www.unboundmedicine.com/medline/citation/19647141/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-857X(09)00024-6 DB - PRIME DP - Unbound Medicine ER -