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Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial.
Lancet. 1990 Jul 21; 336(8708):129-33.Lct

Abstract

In a prospective, randomised, controlled trial to determine whether comprehensive lifestyle changes affect coronary atherosclerosis after 1 year, 28 patients were assigned to an experimental group (low-fat vegetarian diet, stopping smoking, stress management training, and moderate exercise) and 20 to a usual-care control group. 195 coronary artery lesions were analysed by quantitative coronary angiography. The average percentage diameter stenosis regressed from 40.0 (SD 16.9)% to 37.8 (16.5)% in the experimental group yet progressed from 42.7 (15.5)% to 46.1 (18.5)% in the control group. When only lesions greater than 50% stenosed were analysed, the average percentage diameter stenosis regressed from 61.1 (8.8)% to 55.8 (11.0)% in the experimental group and progressed from 61.7 (9.5)% to 64.4 (16.3)% in the control group. Overall, 82% of experimental-group patients had an average change towards regression. Comprehensive lifestyle changes may be able to bring about regression of even severe coronary atherosclerosis after only 1 year, without use of lipid-lowering drugs.

Authors+Show Affiliations

Ornish D
Pacific Presbyterian Medical Center, Sausalito, California.
Brown SE
No affiliation info available
Scherwitz LW
No affiliation info available
Billings JH
No affiliation info available
Armstrong WT
No affiliation info available
Ports TA
No affiliation info available
McLanahan SM
No affiliation info available
Kirkeeide RL
No affiliation info available
Brand RJ
No affiliation info available
Gould KL
No affiliation info available

MeSH

AdultAgedCombined Modality TherapyCoronary AngiographyCoronary Artery DiseaseDiet, VegetarianDietary FatsExerciseFemaleHumansLife StyleLipidsMaleMiddle AgedPatient ComplianceProspective StudiesRandomized Controlled Trials as TopicSex FactorsSmoking PreventionSocial SupportStress, PhysiologicalTime Factors

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1973470

Clinical Trial Links

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Magnetic Resonance Imaging-Portfolio Diet Study #7
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Lifestyle Heart Trial

Citation

Ornish, D, et al. "Can Lifestyle Changes Reverse Coronary Heart Disease? the Lifestyle Heart Trial." Lancet (London, England), vol. 336, no. 8708, 1990, pp. 129-33.
Ornish D, Brown SE, Scherwitz LW, et al. Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial. Lancet. 1990;336(8708):129-33.
Ornish, D., Brown, S. E., Scherwitz, L. W., Billings, J. H., Armstrong, W. T., Ports, T. A., McLanahan, S. M., Kirkeeide, R. L., Brand, R. J., & Gould, K. L. (1990). Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial. Lancet (London, England), 336(8708), 129-33.
Ornish D, et al. Can Lifestyle Changes Reverse Coronary Heart Disease? the Lifestyle Heart Trial. Lancet. 1990 Jul 21;336(8708):129-33. PubMed PMID: 1973470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial. AU - Ornish,D, AU - Brown,S E, AU - Scherwitz,L W, AU - Billings,J H, AU - Armstrong,W T, AU - Ports,T A, AU - McLanahan,S M, AU - Kirkeeide,R L, AU - Brand,R J, AU - Gould,K L, PY - 1990/7/21/pubmed PY - 1990/7/21/medline PY - 1990/7/21/entrez SP - 129 EP - 33 JF - Lancet (London, England) JO - Lancet VL - 336 IS - 8708 N2 - In a prospective, randomised, controlled trial to determine whether comprehensive lifestyle changes affect coronary atherosclerosis after 1 year, 28 patients were assigned to an experimental group (low-fat vegetarian diet, stopping smoking, stress management training, and moderate exercise) and 20 to a usual-care control group. 195 coronary artery lesions were analysed by quantitative coronary angiography. The average percentage diameter stenosis regressed from 40.0 (SD 16.9)% to 37.8 (16.5)% in the experimental group yet progressed from 42.7 (15.5)% to 46.1 (18.5)% in the control group. When only lesions greater than 50% stenosed were analysed, the average percentage diameter stenosis regressed from 61.1 (8.8)% to 55.8 (11.0)% in the experimental group and progressed from 61.7 (9.5)% to 64.4 (16.3)% in the control group. Overall, 82% of experimental-group patients had an average change towards regression. Comprehensive lifestyle changes may be able to bring about regression of even severe coronary atherosclerosis after only 1 year, without use of lipid-lowering drugs. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/1973470/full_citation DB - PRIME DP - Unbound Medicine ER -