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Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial.

Abstract

In a prospective, randomised, controlled trial to determine whether comprehensive lifestyle changes affect coronary atherosclerosis after 1 year, 28 patients were assigned to an experimental group (low-fat vegetarian diet, stopping smoking, stress management training, and moderate exercise) and 20 to a usual-care control group. 195 coronary artery lesions were analysed by quantitative coronary angiography. The average percentage diameter stenosis regressed from 40.0 (SD 16.9)% to 37.8 (16.5)% in the experimental group yet progressed from 42.7 (15.5)% to 46.1 (18.5)% in the control group. When only lesions greater than 50% stenosed were analysed, the average percentage diameter stenosis regressed from 61.1 (8.8)% to 55.8 (11.0)% in the experimental group and progressed from 61.7 (9.5)% to 64.4 (16.3)% in the control group. Overall, 82% of experimental-group patients had an average change towards regression. Comprehensive lifestyle changes may be able to bring about regression of even severe coronary atherosclerosis after only 1 year, without use of lipid-lowering drugs.

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  • Authors+Show Affiliations

    ,

    Pacific Presbyterian Medical Center, Sausalito, California.

    , , , , , , , ,

    Source

    Lancet (London, England) 336:8708 1990 Jul 21 pg 129-33

    MeSH

    Adult
    Aged
    Combined Modality Therapy
    Coronary Angiography
    Coronary Artery Disease
    Diet, Vegetarian
    Dietary Fats
    Exercise
    Female
    Humans
    Life Style
    Lipids
    Male
    Middle Aged
    Patient Compliance
    Prospective Studies
    Randomized Controlled Trials as Topic
    Sex Factors
    Smoking Prevention
    Social Support
    Stress, Physiological
    Time Factors

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    1973470

    Citation

    Ornish, D, et al. "Can Lifestyle Changes Reverse Coronary Heart Disease? the Lifestyle Heart Trial." Lancet (London, England), vol. 336, no. 8708, 1990, pp. 129-33.
    Ornish D, Brown SE, Scherwitz LW, et al. Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial. Lancet. 1990;336(8708):129-33.
    Ornish, D., Brown, S. E., Scherwitz, L. W., Billings, J. H., Armstrong, W. T., Ports, T. A., ... Gould, K. L. (1990). Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial. Lancet (London, England), 336(8708), pp. 129-33.
    Ornish D, et al. Can Lifestyle Changes Reverse Coronary Heart Disease? the Lifestyle Heart Trial. Lancet. 1990 Jul 21;336(8708):129-33. PubMed PMID: 1973470.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial. AU - Ornish,D, AU - Brown,S E, AU - Scherwitz,L W, AU - Billings,J H, AU - Armstrong,W T, AU - Ports,T A, AU - McLanahan,S M, AU - Kirkeeide,R L, AU - Brand,R J, AU - Gould,K L, PY - 1990/7/21/pubmed PY - 1990/7/21/medline PY - 1990/7/21/entrez SP - 129 EP - 33 JF - Lancet (London, England) JO - Lancet VL - 336 IS - 8708 N2 - In a prospective, randomised, controlled trial to determine whether comprehensive lifestyle changes affect coronary atherosclerosis after 1 year, 28 patients were assigned to an experimental group (low-fat vegetarian diet, stopping smoking, stress management training, and moderate exercise) and 20 to a usual-care control group. 195 coronary artery lesions were analysed by quantitative coronary angiography. The average percentage diameter stenosis regressed from 40.0 (SD 16.9)% to 37.8 (16.5)% in the experimental group yet progressed from 42.7 (15.5)% to 46.1 (18.5)% in the control group. When only lesions greater than 50% stenosed were analysed, the average percentage diameter stenosis regressed from 61.1 (8.8)% to 55.8 (11.0)% in the experimental group and progressed from 61.7 (9.5)% to 64.4 (16.3)% in the control group. Overall, 82% of experimental-group patients had an average change towards regression. Comprehensive lifestyle changes may be able to bring about regression of even severe coronary atherosclerosis after only 1 year, without use of lipid-lowering drugs. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/1973470/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/0140-6736(90)91656-U DB - PRIME DP - Unbound Medicine ER -