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Major eye diseases and risk factors associated with systemic hypertension in an adult Chinese population: the Beijing Eye Study.
Ophthalmology 2009; 116(12):2373-80O

Abstract

PURPOSE

To assess the relationship of hypertension with major eye diseases and other ocular parameters.

DESIGN

Population-based study.

PARTICIPANTS

The Beijing Eye Study is a population-based study that included 4439 Chinese subjects examined at the baseline examination in 2001; there was a follow-up examination in 2006, in which 3251 subjects participated, of whom 3222 had blood pressure measurements.

METHODS

All participants underwent an ophthalmic examination, anthropometric measurements, and blood pressure measurement. Hypertension was defined as a systolic blood pressure >or=140 mmHg and/or diastolic blood pressure >or=90 mmHg, and/or self-reported current treatment for hypertension with antihypertensive medication.

MAIN OUTCOME MEASURES

Blood pressure and ocular parameters, including intraocular pressure and prevalence of major ophthalmic diseases.

RESULTS

Mean age of participants in the present study was 60.4+/-10.0 years. Hypertension was present in 1500 (46.6%) of the 3222 subjects who had their blood pressure measured. In multiple regression analysis, hypertension was associated with higher intraocular pressure (beta = 0.39; 95% confidence interval [CI], 0.12-0.66; P = 0.005), focal arteriolar narrowing (odds ratio [OR], 1.78; 95% CI, 1.34-2.36; P<0.001), arteriovenous nicking (OR, 1.50; 95% CI, 1.11-2.04; P = 0.009), generalized retinal arteriolar narrowing (OR, 1.65; 95% CI, 1.30-2.09; P<0.001), retinal vein occlusions (OR, 2.86; 95% CI, 1.21-6.80; P = 0.02), and diabetic retinopathy (OR, 1.90; 95% CI, 1.08-3.31; P = 0.02). Hypertension was not significantly associated with the prevalence of open-angle glaucoma (P = 0.19), angle-closure glaucoma (P = 0.15), age-related macular degeneration (AMD) (P = 0.73), nuclear cataract (P = 0.88), posterior subcapsular cataract (P = 0.30), cortical cataract (P = 0.10), or area of alpha zone (P = 0.05) or beta zone of parapapillary atrophy (P = 0.95).

CONCLUSIONS

In Chinese persons, while controlling for other systemic parameters, hypertension was associated with increased intraocular pressure, retinal microvascular abnormalities, and prevalence of retinal vein occlusion and diabetic retinopathy. Hypertension was not associated significantly with AMD, age-related cataract, or glaucoma.

Authors+Show Affiliations

Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19815279

Citation

Wang, Shuang, et al. "Major Eye Diseases and Risk Factors Associated With Systemic Hypertension in an Adult Chinese Population: the Beijing Eye Study." Ophthalmology, vol. 116, no. 12, 2009, pp. 2373-80.
Wang S, Xu L, Jonas JB, et al. Major eye diseases and risk factors associated with systemic hypertension in an adult Chinese population: the Beijing Eye Study. Ophthalmology. 2009;116(12):2373-80.
Wang, S., Xu, L., Jonas, J. B., Wong, T. Y., Cui, T., Li, Y., ... Sun, C. (2009). Major eye diseases and risk factors associated with systemic hypertension in an adult Chinese population: the Beijing Eye Study. Ophthalmology, 116(12), pp. 2373-80. doi:10.1016/j.ophtha.2009.05.041.
Wang S, et al. Major Eye Diseases and Risk Factors Associated With Systemic Hypertension in an Adult Chinese Population: the Beijing Eye Study. Ophthalmology. 2009;116(12):2373-80. PubMed PMID: 19815279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Major eye diseases and risk factors associated with systemic hypertension in an adult Chinese population: the Beijing Eye Study. AU - Wang,Shuang, AU - Xu,Liang, AU - Jonas,Jost B, AU - Wong,Tien Y, AU - Cui,Tongtong, AU - Li,Yibin, AU - Wang,Ya Xing, AU - You,Qi Sheng, AU - Yang,Hua, AU - Sun,Cong, Y1 - 2009/10/07/ PY - 2009/02/16/received PY - 2009/04/21/revised PY - 2009/05/29/accepted PY - 2009/10/10/entrez PY - 2009/10/10/pubmed PY - 2009/12/16/medline SP - 2373 EP - 80 JF - Ophthalmology JO - Ophthalmology VL - 116 IS - 12 N2 - PURPOSE: To assess the relationship of hypertension with major eye diseases and other ocular parameters. DESIGN: Population-based study. PARTICIPANTS: The Beijing Eye Study is a population-based study that included 4439 Chinese subjects examined at the baseline examination in 2001; there was a follow-up examination in 2006, in which 3251 subjects participated, of whom 3222 had blood pressure measurements. METHODS: All participants underwent an ophthalmic examination, anthropometric measurements, and blood pressure measurement. Hypertension was defined as a systolic blood pressure >or=140 mmHg and/or diastolic blood pressure >or=90 mmHg, and/or self-reported current treatment for hypertension with antihypertensive medication. MAIN OUTCOME MEASURES: Blood pressure and ocular parameters, including intraocular pressure and prevalence of major ophthalmic diseases. RESULTS: Mean age of participants in the present study was 60.4+/-10.0 years. Hypertension was present in 1500 (46.6%) of the 3222 subjects who had their blood pressure measured. In multiple regression analysis, hypertension was associated with higher intraocular pressure (beta = 0.39; 95% confidence interval [CI], 0.12-0.66; P = 0.005), focal arteriolar narrowing (odds ratio [OR], 1.78; 95% CI, 1.34-2.36; P<0.001), arteriovenous nicking (OR, 1.50; 95% CI, 1.11-2.04; P = 0.009), generalized retinal arteriolar narrowing (OR, 1.65; 95% CI, 1.30-2.09; P<0.001), retinal vein occlusions (OR, 2.86; 95% CI, 1.21-6.80; P = 0.02), and diabetic retinopathy (OR, 1.90; 95% CI, 1.08-3.31; P = 0.02). Hypertension was not significantly associated with the prevalence of open-angle glaucoma (P = 0.19), angle-closure glaucoma (P = 0.15), age-related macular degeneration (AMD) (P = 0.73), nuclear cataract (P = 0.88), posterior subcapsular cataract (P = 0.30), cortical cataract (P = 0.10), or area of alpha zone (P = 0.05) or beta zone of parapapillary atrophy (P = 0.95). CONCLUSIONS: In Chinese persons, while controlling for other systemic parameters, hypertension was associated with increased intraocular pressure, retinal microvascular abnormalities, and prevalence of retinal vein occlusion and diabetic retinopathy. Hypertension was not associated significantly with AMD, age-related cataract, or glaucoma. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/19815279/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(09)00601-0 DB - PRIME DP - Unbound Medicine ER -