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Incidence of and potential risk factors for gallstone disease in a general population sample.

Abstract

BACKGROUND

Several epidemiological studies have been published, but there are few reports on relations between gallstone incidence, symptomatology and risk factors.

METHODS

Of 621 randomly selected individuals aged 35-85 years in a general population who had been screened previously with ultrasonography and found to have no gallbladder stones, 503 (81.0 per cent) were re-examined after a minimum interval of 5 years. At baseline and re-examination, heredity for gallstone disease was explored and body mass index, digestive symptoms including abdominal pain, quality of life, alcohol and smoking habits, use of non-steroidal anti-inflammatory drugs and oestrogen, parity and blood lipid levels were recorded.

RESULTS

Forty-two (8.3 per cent) of the 503 subjects developed stones. Subjects were followed for a total of 3025.8 person-years, yielding an incidence for newly developed gallstones of 1.39 per 100 person-years. A positive association for gallstone development was found only for length of follow-up and plasma low-density lipoprotein-cholesterol levels at baseline. Weekly alcohol consumption was inversely related to gallstone development.

CONCLUSION

The incidence of gallstones in this population was 1.39 per 100 person-years. Gallstone development was related to length of follow-up and LDL-cholesterol levels, and inversely related to alcohol consumption.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Surgery, University Hospital of Linköping, Linköping, Sweden. ingvar.halldestam@lio.se

    ,

    Source

    The British journal of surgery 96:11 2009 Nov pg 1315-22

    MeSH

    Adult
    Age Distribution
    Aged
    Aged, 80 and over
    Body Mass Index
    Female
    Gallstones
    Humans
    Incidence
    Male
    Middle Aged
    Prejudice
    Quality of Life
    Risk Factors
    Rural Health
    Sweden
    Urban Health

    Pub Type(s)

    Journal Article
    Multicenter Study

    Language

    eng

    PubMed ID

    19847878

    Citation

    Halldestam, I, et al. "Incidence of and Potential Risk Factors for Gallstone Disease in a General Population Sample." The British Journal of Surgery, vol. 96, no. 11, 2009, pp. 1315-22.
    Halldestam I, Kullman E, Borch K. Incidence of and potential risk factors for gallstone disease in a general population sample. Br J Surg. 2009;96(11):1315-22.
    Halldestam, I., Kullman, E., & Borch, K. (2009). Incidence of and potential risk factors for gallstone disease in a general population sample. The British Journal of Surgery, 96(11), pp. 1315-22. doi:10.1002/bjs.6687.
    Halldestam I, Kullman E, Borch K. Incidence of and Potential Risk Factors for Gallstone Disease in a General Population Sample. Br J Surg. 2009;96(11):1315-22. PubMed PMID: 19847878.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Incidence of and potential risk factors for gallstone disease in a general population sample. AU - Halldestam,I, AU - Kullman,E, AU - Borch,K, PY - 2009/10/23/entrez PY - 2009/10/23/pubmed PY - 2009/12/16/medline SP - 1315 EP - 22 JF - The British journal of surgery JO - Br J Surg VL - 96 IS - 11 N2 - BACKGROUND: Several epidemiological studies have been published, but there are few reports on relations between gallstone incidence, symptomatology and risk factors. METHODS: Of 621 randomly selected individuals aged 35-85 years in a general population who had been screened previously with ultrasonography and found to have no gallbladder stones, 503 (81.0 per cent) were re-examined after a minimum interval of 5 years. At baseline and re-examination, heredity for gallstone disease was explored and body mass index, digestive symptoms including abdominal pain, quality of life, alcohol and smoking habits, use of non-steroidal anti-inflammatory drugs and oestrogen, parity and blood lipid levels were recorded. RESULTS: Forty-two (8.3 per cent) of the 503 subjects developed stones. Subjects were followed for a total of 3025.8 person-years, yielding an incidence for newly developed gallstones of 1.39 per 100 person-years. A positive association for gallstone development was found only for length of follow-up and plasma low-density lipoprotein-cholesterol levels at baseline. Weekly alcohol consumption was inversely related to gallstone development. CONCLUSION: The incidence of gallstones in this population was 1.39 per 100 person-years. Gallstone development was related to length of follow-up and LDL-cholesterol levels, and inversely related to alcohol consumption. SN - 1365-2168 UR - https://www.unboundmedicine.com/medline/citation/19847878/full_citation L2 - https://doi.org/10.1002/bjs.6687 DB - PRIME DP - Unbound Medicine ER -