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Incidence of and potential risk factors for gallstone disease in a general population sample.
Br J Surg 2009; 96(11):1315-22BJ

Abstract

BACKGROUND

Several epidemiological studies have been published, but there are few reports on relations between gallstone incidence, symptomatology and risk factors.

METHODS

Of 621 randomly selected individuals aged 35-85 years in a general population who had been screened previously with ultrasonography and found to have no gallbladder stones, 503 (81.0 per cent) were re-examined after a minimum interval of 5 years. At baseline and re-examination, heredity for gallstone disease was explored and body mass index, digestive symptoms including abdominal pain, quality of life, alcohol and smoking habits, use of non-steroidal anti-inflammatory drugs and oestrogen, parity and blood lipid levels were recorded.

RESULTS

Forty-two (8.3 per cent) of the 503 subjects developed stones. Subjects were followed for a total of 3025.8 person-years, yielding an incidence for newly developed gallstones of 1.39 per 100 person-years. A positive association for gallstone development was found only for length of follow-up and plasma low-density lipoprotein-cholesterol levels at baseline. Weekly alcohol consumption was inversely related to gallstone development.

CONCLUSION

The incidence of gallstones in this population was 1.39 per 100 person-years. Gallstone development was related to length of follow-up and LDL-cholesterol levels, and inversely related to alcohol consumption.

Authors+Show Affiliations

Department of Surgery, University Hospital of Linköping, Linköping, Sweden. ingvar.halldestam@lio.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

19847878

Citation

Halldestam, I, et al. "Incidence of and Potential Risk Factors for Gallstone Disease in a General Population Sample." The British Journal of Surgery, vol. 96, no. 11, 2009, pp. 1315-22.
Halldestam I, Kullman E, Borch K. Incidence of and potential risk factors for gallstone disease in a general population sample. Br J Surg. 2009;96(11):1315-22.
Halldestam, I., Kullman, E., & Borch, K. (2009). Incidence of and potential risk factors for gallstone disease in a general population sample. The British Journal of Surgery, 96(11), pp. 1315-22. doi:10.1002/bjs.6687.
Halldestam I, Kullman E, Borch K. Incidence of and Potential Risk Factors for Gallstone Disease in a General Population Sample. Br J Surg. 2009;96(11):1315-22. PubMed PMID: 19847878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence of and potential risk factors for gallstone disease in a general population sample. AU - Halldestam,I, AU - Kullman,E, AU - Borch,K, PY - 2009/10/23/entrez PY - 2009/10/23/pubmed PY - 2009/12/16/medline SP - 1315 EP - 22 JF - The British journal of surgery JO - Br J Surg VL - 96 IS - 11 N2 - BACKGROUND: Several epidemiological studies have been published, but there are few reports on relations between gallstone incidence, symptomatology and risk factors. METHODS: Of 621 randomly selected individuals aged 35-85 years in a general population who had been screened previously with ultrasonography and found to have no gallbladder stones, 503 (81.0 per cent) were re-examined after a minimum interval of 5 years. At baseline and re-examination, heredity for gallstone disease was explored and body mass index, digestive symptoms including abdominal pain, quality of life, alcohol and smoking habits, use of non-steroidal anti-inflammatory drugs and oestrogen, parity and blood lipid levels were recorded. RESULTS: Forty-two (8.3 per cent) of the 503 subjects developed stones. Subjects were followed for a total of 3025.8 person-years, yielding an incidence for newly developed gallstones of 1.39 per 100 person-years. A positive association for gallstone development was found only for length of follow-up and plasma low-density lipoprotein-cholesterol levels at baseline. Weekly alcohol consumption was inversely related to gallstone development. CONCLUSION: The incidence of gallstones in this population was 1.39 per 100 person-years. Gallstone development was related to length of follow-up and LDL-cholesterol levels, and inversely related to alcohol consumption. SN - 1365-2168 UR - https://www.unboundmedicine.com/medline/citation/19847878/full_citation L2 - https://doi.org/10.1002/bjs.6687 DB - PRIME DP - Unbound Medicine ER -