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Conditions and drugs interfering with thyroxine absorption.

Abstract

Food, dietary fibre and espresso coffee interfere with the absorption of levothyroxine. Malabsorptive disorders reported to affect the absorption of levothyroxine include coeliac disease, inflammatory bowel disease, lactose intolerance as well as Helicobacter pylori (H. pylori) infection and atrophic gastritis. Many commonly used drugs, such as bile acid sequestrants, ferrous sulphate, sucralfate, calcium carbonate, aluminium-containing antacids, phosphate binders, raloxifene and proton-pump inhibitors, have also been shown to interfere with the absorption of levothyroxine.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Endocrinology, VA Greater Los Angeles Healthcare System, Endocrinology 111D, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA. liwanpol@cshs.org

    Source

    MeSH

    Aluminum Hydroxide
    Animals
    Antacids
    Biological Availability
    Calcium Carbonate
    Celiac Disease
    Coffee
    Dietary Fiber
    Drug Interactions
    Female
    Food
    Gastritis, Atrophic
    Helicobacter Infections
    Humans
    Intestinal Absorption
    Lactose Intolerance
    Malabsorption Syndromes
    Thyroxine

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    19942153

    Citation

    TY - JOUR T1 - Conditions and drugs interfering with thyroxine absorption. AU - Liwanpo,Llanyee, AU - Hershman,Jerome M, PY - 2009/11/28/entrez PY - 2009/11/28/pubmed PY - 2010/2/13/medline SP - 781 EP - 92 JF - Best practice & research. Clinical endocrinology & metabolism JO - Best Pract. Res. Clin. Endocrinol. Metab. VL - 23 IS - 6 N2 - Food, dietary fibre and espresso coffee interfere with the absorption of levothyroxine. Malabsorptive disorders reported to affect the absorption of levothyroxine include coeliac disease, inflammatory bowel disease, lactose intolerance as well as Helicobacter pylori (H. pylori) infection and atrophic gastritis. Many commonly used drugs, such as bile acid sequestrants, ferrous sulphate, sucralfate, calcium carbonate, aluminium-containing antacids, phosphate binders, raloxifene and proton-pump inhibitors, have also been shown to interfere with the absorption of levothyroxine. SN - 1878-1594 UR - https://www.unboundmedicine.com/medline/citation/19942153/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-690X(09)00076-1 ER -