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Oxidative stress in acne vulgaris.
J Eur Acad Dermatol Venereol. 2010 Jul; 24(7):763-7.JE

Abstract

BACKGROUND

Acne vulgaris is one of the common dermatological diseases and its pathogenesis is multifactorial. In this study, we aimed to determine the effects of oxidative stress in acne vulgaris.

MATERIALS AND METHODS

The study involved 32 patients with acne vulgaris in the patient group and 34 healthy adults in the control group. The parameters of oxidative stress such as catalase (CAT), superoxide dismutase (SOD), xanthine oxidase (XO), nitric oxide (NO) and malondialdehyde (MDA) in the venous blood of patients were measured spectrophotometrically. The values were compared with those of the control group.

RESULTS

The serum levels of MDA and XO activity in the patients with acne vulgaris were significantly higher than those of the controls. A significantly lower SOD and CAT activity was found in the patient group than in the control group. Although the patient group had higher serum levels of NO than the control group, the difference was not statistically significant.

CONCLUSION

These results suggest that oxidative damage may play a role in the pathogenesis of acne; therefore, significant alterations may occur in the antioxidant defence system.

Authors+Show Affiliations

Department of Dermatology, Zonguldak Karaelmas University, Zonguldak, Turkey. gulbensarici@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19943837

Citation

Sarici, G, et al. "Oxidative Stress in Acne Vulgaris." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 24, no. 7, 2010, pp. 763-7.
Sarici G, Cinar S, Armutcu F, et al. Oxidative stress in acne vulgaris. J Eur Acad Dermatol Venereol. 2010;24(7):763-7.
Sarici, G., Cinar, S., Armutcu, F., Altinyazar, C., Koca, R., & Tekin, N. S. (2010). Oxidative stress in acne vulgaris. Journal of the European Academy of Dermatology and Venereology : JEADV, 24(7), 763-7. https://doi.org/10.1111/j.1468-3083.2009.03505.x
Sarici G, et al. Oxidative Stress in Acne Vulgaris. J Eur Acad Dermatol Venereol. 2010;24(7):763-7. PubMed PMID: 19943837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress in acne vulgaris. AU - Sarici,G, AU - Cinar,S, AU - Armutcu,F, AU - Altinyazar,C, AU - Koca,R, AU - Tekin,N S, Y1 - 2009/11/23/ PY - 2009/12/1/entrez PY - 2009/12/1/pubmed PY - 2010/11/9/medline SP - 763 EP - 7 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 24 IS - 7 N2 - BACKGROUND: Acne vulgaris is one of the common dermatological diseases and its pathogenesis is multifactorial. In this study, we aimed to determine the effects of oxidative stress in acne vulgaris. MATERIALS AND METHODS: The study involved 32 patients with acne vulgaris in the patient group and 34 healthy adults in the control group. The parameters of oxidative stress such as catalase (CAT), superoxide dismutase (SOD), xanthine oxidase (XO), nitric oxide (NO) and malondialdehyde (MDA) in the venous blood of patients were measured spectrophotometrically. The values were compared with those of the control group. RESULTS: The serum levels of MDA and XO activity in the patients with acne vulgaris were significantly higher than those of the controls. A significantly lower SOD and CAT activity was found in the patient group than in the control group. Although the patient group had higher serum levels of NO than the control group, the difference was not statistically significant. CONCLUSION: These results suggest that oxidative damage may play a role in the pathogenesis of acne; therefore, significant alterations may occur in the antioxidant defence system. SN - 1468-3083 UR - https://www.unboundmedicine.com/medline/citation/19943837/Oxidative_stress_in_acne_vulgaris_ L2 - https://doi.org/10.1111/j.1468-3083.2009.03505.x DB - PRIME DP - Unbound Medicine ER -