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A prospective study of dairy intake and risk of uterine leiomyomata.
Am J Epidemiol 2010; 171(2):221-32AJ

Abstract

Rates of uterine leiomyomata are 2-3 times higher among black women than white women. Dietary factors that differ in prevalence between these populations that could contribute to the disparity include dairy intake. During 1997-2007, the authors followed 22,120 premenopausal US Black Women's Health Study participants to assess dairy intake in relation to uterine leiomyomata risk. Because soy may be substituted for dairy, the effect of soy intake was also evaluated. Diet was estimated by using food frequency questionnaires in 1995 and 2001. Incidence rate ratios and 95% confidence intervals were estimated with Cox regression. There were 5,871 incident cases of uterine leiomyomata diagnosed by ultrasound (n = 3,964) or surgery (n = 1,907). Multivariable incidence rate ratios comparing 1, 2, 3, and > or =4 servings/day with <1 serving/day of total dairy were 0.94 (95% confidence interval (CI): 0.88, 1.00), 0.87 (95% CI: 0.78, 0.98), 0.84 (95% CI: 0.70, 1.01), and 0.70 (95% CI: 0.58, 0.86), respectively (P-trend <0.001). Incidence rate ratios comparing the highest (> or =2 servings/day) with the lowest (<1 serving/week) intake categories were 0.81 (95% CI: 0.66, 0.99) for high-fat dairy, 0.80 (95% CI: 0.70, 0.91) for low-fat dairy, and 0.78 (95% CI: 0.68, 0.89) for milk. Soy intake was unrelated to uterine leiomyomata risk. This large prospective study of black women provides the first epidemiologic evidence of reduced uterine leiomyomata risk associated with dairy consumption.

Authors+Show Affiliations

Slone Epidemiology Center, 1010 Commonwealth Avenue, Boston, MA 02215, USA. lwise@bu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19955473

Citation

Wise, Lauren A., et al. "A Prospective Study of Dairy Intake and Risk of Uterine Leiomyomata." American Journal of Epidemiology, vol. 171, no. 2, 2010, pp. 221-32.
Wise LA, Radin RG, Palmer JR, et al. A prospective study of dairy intake and risk of uterine leiomyomata. Am J Epidemiol. 2010;171(2):221-32.
Wise, L. A., Radin, R. G., Palmer, J. R., Kumanyika, S. K., & Rosenberg, L. (2010). A prospective study of dairy intake and risk of uterine leiomyomata. American Journal of Epidemiology, 171(2), pp. 221-32. doi:10.1093/aje/kwp355.
Wise LA, et al. A Prospective Study of Dairy Intake and Risk of Uterine Leiomyomata. Am J Epidemiol. 2010 Jan 15;171(2):221-32. PubMed PMID: 19955473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of dairy intake and risk of uterine leiomyomata. AU - Wise,Lauren A, AU - Radin,Rose G, AU - Palmer,Julie R, AU - Kumanyika,Shiriki K, AU - Rosenberg,Lynn, Y1 - 2009/12/02/ PY - 2009/12/4/entrez PY - 2009/12/4/pubmed PY - 2010/2/17/medline SP - 221 EP - 32 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 171 IS - 2 N2 - Rates of uterine leiomyomata are 2-3 times higher among black women than white women. Dietary factors that differ in prevalence between these populations that could contribute to the disparity include dairy intake. During 1997-2007, the authors followed 22,120 premenopausal US Black Women's Health Study participants to assess dairy intake in relation to uterine leiomyomata risk. Because soy may be substituted for dairy, the effect of soy intake was also evaluated. Diet was estimated by using food frequency questionnaires in 1995 and 2001. Incidence rate ratios and 95% confidence intervals were estimated with Cox regression. There were 5,871 incident cases of uterine leiomyomata diagnosed by ultrasound (n = 3,964) or surgery (n = 1,907). Multivariable incidence rate ratios comparing 1, 2, 3, and > or =4 servings/day with <1 serving/day of total dairy were 0.94 (95% confidence interval (CI): 0.88, 1.00), 0.87 (95% CI: 0.78, 0.98), 0.84 (95% CI: 0.70, 1.01), and 0.70 (95% CI: 0.58, 0.86), respectively (P-trend <0.001). Incidence rate ratios comparing the highest (> or =2 servings/day) with the lowest (<1 serving/week) intake categories were 0.81 (95% CI: 0.66, 0.99) for high-fat dairy, 0.80 (95% CI: 0.70, 0.91) for low-fat dairy, and 0.78 (95% CI: 0.68, 0.89) for milk. Soy intake was unrelated to uterine leiomyomata risk. This large prospective study of black women provides the first epidemiologic evidence of reduced uterine leiomyomata risk associated with dairy consumption. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/19955473/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwp355 DB - PRIME DP - Unbound Medicine ER -