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The association of increasing body mass index and kidney stone disease.

Abstract

PURPOSE

Previous epidemiological works have reported that obesity is a risk factor for kidney stone disease. However, the effect of increasing degrees of obesity on stone formation has yet to be defined. To address this question we examined how an increasing body mass index affects the risk of kidney stone disease.

MATERIALS AND METHODS

We evaluated claims from a 5-year period (2002 to 2006) in a national private insurance database to identify subjects diagnosed with or treated for kidney stones. From a data set of 95,598 patients, subjects were identified by ICD-9 or CPT codes specific to kidney stone disease. Descriptive analyses were performed and odds ratios were calculated.

RESULTS

Gender distribution of the 3,257 stone formers was 42.9% male and 57.1% female. Obesity (body mass index greater than 30 kg/m(2)) was associated with a significantly greater likelihood of being diagnosed with a kidney stone. However, when obese patients were stratified by body mass index there were no significant differences in the likelihood of a kidney stone diagnosis, suggesting a stabilization of risk once body mass index increased above 30 kg/m(2). The association of body mass index and a stone removal procedure was significant only for men and women with a body mass index between 30 and 45 kg/m(2) relative to a body mass index less than 25 kg/m(2) (p <0.001).

CONCLUSIONS

An obese body mass index is associated with an increased risk of kidney stone disease. However, the magnitude of this risk appears to be stable in the morbidly obese population. Once body mass index is greater than 30 kg/m(2), further increases do not appear to significantly increase the risk of stone disease.

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  • Authors+Show Affiliations

    ,

    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

    , , , ,

    Source

    The Journal of urology 183:2 2010 Feb pg 571-5

    MeSH

    Body Mass Index
    Female
    Humans
    Kidney Calculi
    Male
    Middle Aged
    Prevalence
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    20018330

    Citation

    Semins, Michelle J., et al. "The Association of Increasing Body Mass Index and Kidney Stone Disease." The Journal of Urology, vol. 183, no. 2, 2010, pp. 571-5.
    Semins MJ, Shore AD, Makary MA, et al. The association of increasing body mass index and kidney stone disease. J Urol. 2010;183(2):571-5.
    Semins, M. J., Shore, A. D., Makary, M. A., Magnuson, T., Johns, R., & Matlaga, B. R. (2010). The association of increasing body mass index and kidney stone disease. The Journal of Urology, 183(2), pp. 571-5. doi:10.1016/j.juro.2009.09.085.
    Semins MJ, et al. The Association of Increasing Body Mass Index and Kidney Stone Disease. J Urol. 2010;183(2):571-5. PubMed PMID: 20018330.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The association of increasing body mass index and kidney stone disease. AU - Semins,Michelle J, AU - Shore,Andrew D, AU - Makary,Martin A, AU - Magnuson,Thomas, AU - Johns,Roger, AU - Matlaga,Brian R, Y1 - 2009/12/16/ PY - 2009/05/29/received PY - 2009/12/19/entrez PY - 2009/12/19/pubmed PY - 2010/2/24/medline SP - 571 EP - 5 JF - The Journal of urology JO - J. Urol. VL - 183 IS - 2 N2 - PURPOSE: Previous epidemiological works have reported that obesity is a risk factor for kidney stone disease. However, the effect of increasing degrees of obesity on stone formation has yet to be defined. To address this question we examined how an increasing body mass index affects the risk of kidney stone disease. MATERIALS AND METHODS: We evaluated claims from a 5-year period (2002 to 2006) in a national private insurance database to identify subjects diagnosed with or treated for kidney stones. From a data set of 95,598 patients, subjects were identified by ICD-9 or CPT codes specific to kidney stone disease. Descriptive analyses were performed and odds ratios were calculated. RESULTS: Gender distribution of the 3,257 stone formers was 42.9% male and 57.1% female. Obesity (body mass index greater than 30 kg/m(2)) was associated with a significantly greater likelihood of being diagnosed with a kidney stone. However, when obese patients were stratified by body mass index there were no significant differences in the likelihood of a kidney stone diagnosis, suggesting a stabilization of risk once body mass index increased above 30 kg/m(2). The association of body mass index and a stone removal procedure was significant only for men and women with a body mass index between 30 and 45 kg/m(2) relative to a body mass index less than 25 kg/m(2) (p <0.001). CONCLUSIONS: An obese body mass index is associated with an increased risk of kidney stone disease. However, the magnitude of this risk appears to be stable in the morbidly obese population. Once body mass index is greater than 30 kg/m(2), further increases do not appear to significantly increase the risk of stone disease. SN - 1527-3792 UR - https://www.unboundmedicine.com/medline/citation/20018330/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-5347(09)02626-3 DB - PRIME DP - Unbound Medicine ER -