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Food allergy.
J Allergy Clin Immunol 2010; 125(2 Suppl 2):S116-25JA

Abstract

Adverse immune responses to foods affect approximately 5% of young children and 3% to 4% of adults in westernized countries and appear to have increased in prevalence. Food-induced allergic reactions are responsible for a variety of symptoms and disorders involving the skin and gastrointestinal and respiratory tracts and can be attributed to IgE-mediated and non-IgE-mediated (cellular) mechanisms. Genetic disposition and environmental factors might abrogate oral tolerance, leading to food allergy. Disease outcomes are influenced by the characteristics of the immune response and of the triggering allergen. Diagnosis is complicated by the observation that detection of food-specific IgE (sensitization) does not necessarily indicate clinical allergy. Therefore diagnosis requires a careful medical history, laboratory studies, and, in many cases, an oral food challenge to confirm a diagnosis. Novel diagnostic methods, including ones that focus on immune responses to specific food proteins or epitopes of specific proteins, are under study. Currently, management of food allergies consists of educating the patient to avoid ingesting the responsible allergen and to initiate therapy (eg, with injected epinephrine for anaphylaxis) in case of an unintended ingestion. Improved therapeutic strategies under study include oral and sublingual immunotherapy, Chinese herbal medicine, anti-IgE antibodies, and modified vaccines.

Authors+Show Affiliations

Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029-6574, USA. scott.sicherer@mssm.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20042231

Citation

Sicherer, Scott H., and Hugh A. Sampson. "Food Allergy." The Journal of Allergy and Clinical Immunology, vol. 125, no. 2 Suppl 2, 2010, pp. S116-25.
Sicherer SH, Sampson HA. Food allergy. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S116-25.
Sicherer, S. H., & Sampson, H. A. (2010). Food allergy. The Journal of Allergy and Clinical Immunology, 125(2 Suppl 2), pp. S116-25. doi:10.1016/j.jaci.2009.08.028.
Sicherer SH, Sampson HA. Food Allergy. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S116-25. PubMed PMID: 20042231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Food allergy. AU - Sicherer,Scott H, AU - Sampson,Hugh A, Y1 - 2009/12/29/ PY - 2009/07/20/received PY - 2009/08/18/revised PY - 2009/08/21/accepted PY - 2010/1/1/entrez PY - 2010/1/1/pubmed PY - 2010/4/10/medline SP - S116 EP - 25 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 125 IS - 2 Suppl 2 N2 - Adverse immune responses to foods affect approximately 5% of young children and 3% to 4% of adults in westernized countries and appear to have increased in prevalence. Food-induced allergic reactions are responsible for a variety of symptoms and disorders involving the skin and gastrointestinal and respiratory tracts and can be attributed to IgE-mediated and non-IgE-mediated (cellular) mechanisms. Genetic disposition and environmental factors might abrogate oral tolerance, leading to food allergy. Disease outcomes are influenced by the characteristics of the immune response and of the triggering allergen. Diagnosis is complicated by the observation that detection of food-specific IgE (sensitization) does not necessarily indicate clinical allergy. Therefore diagnosis requires a careful medical history, laboratory studies, and, in many cases, an oral food challenge to confirm a diagnosis. Novel diagnostic methods, including ones that focus on immune responses to specific food proteins or epitopes of specific proteins, are under study. Currently, management of food allergies consists of educating the patient to avoid ingesting the responsible allergen and to initiate therapy (eg, with injected epinephrine for anaphylaxis) in case of an unintended ingestion. Improved therapeutic strategies under study include oral and sublingual immunotherapy, Chinese herbal medicine, anti-IgE antibodies, and modified vaccines. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/20042231/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(09)01270-6 DB - PRIME DP - Unbound Medicine ER -