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Diet, lifestyle, and acute myeloid leukemia in the NIH-AARP cohort.
Am J Epidemiol 2010; 171(3):312-22AJ

Abstract

The relation between diet, lifestyle, and acute myeloid leukemia was assessed in a US cohort of 491,163 persons from the NIH-AARP Diet and Health Study (1995-2003). A total of 338 incident cases of acute myeloid leukemia were ascertained. Multivariate Cox models were utilized to estimate hazard ratios and 95% confidence intervals. Compared with those for never smokers, hazard ratios were 1.29 (95% confidence interval: 0.95, 1.75), 1.79 (95% confidence interval: 1.32, 2.42), 2.42 (95% confidence interval: 1.63, 3.57), and 2.29 (85% confidence interval: 1.38, 3.79) for former smokers who smoked < or =1 or >1 pack/day and for current smokers who smoked < or =1 or >1 pack/day, respectively. Higher meat intake was associated with an increased risk of acute myeloid leukemia (hazard ratio = 1.45, 95% confidence interval: 1.02, 2.07 for the fifth vs. first quintile; P for trend = 0.06); however, there were no clear effects of meat-cooking method or doneness level. Individuals who did not drink coffee appeared to have a higher risk of acute myeloid leukemia than those who drank various quantities of coffee. Neither fruit nor vegetable intake was associated with acute myeloid leukemia. This large prospective study identified smoking and meat intake as risk factors for acute myeloid leukemia.

Authors+Show Affiliations

Division of Chronic Disease Epidemiology, Yale University School of Public Health, New Haven, Connecticut, USA. xiaomei.ma@yale.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

20042434

Citation

Ma, Xiaomei, et al. "Diet, Lifestyle, and Acute Myeloid Leukemia in the NIH-AARP Cohort." American Journal of Epidemiology, vol. 171, no. 3, 2010, pp. 312-22.
Ma X, Park Y, Mayne ST, et al. Diet, lifestyle, and acute myeloid leukemia in the NIH-AARP cohort. Am J Epidemiol. 2010;171(3):312-22.
Ma, X., Park, Y., Mayne, S. T., Wang, R., Sinha, R., Hollenbeck, A. R., ... Cross, A. J. (2010). Diet, lifestyle, and acute myeloid leukemia in the NIH-AARP cohort. American Journal of Epidemiology, 171(3), pp. 312-22. doi:10.1093/aje/kwp371.
Ma X, et al. Diet, Lifestyle, and Acute Myeloid Leukemia in the NIH-AARP Cohort. Am J Epidemiol. 2010 Feb 1;171(3):312-22. PubMed PMID: 20042434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet, lifestyle, and acute myeloid leukemia in the NIH-AARP cohort. AU - Ma,Xiaomei, AU - Park,Yikyung, AU - Mayne,Susan T, AU - Wang,Rong, AU - Sinha,Rashmi, AU - Hollenbeck,Albert R, AU - Schatzkin,Arthur, AU - Cross,Amanda J, Y1 - 2009/12/30/ PY - 2010/1/1/entrez PY - 2010/1/1/pubmed PY - 2010/1/30/medline SP - 312 EP - 22 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 171 IS - 3 N2 - The relation between diet, lifestyle, and acute myeloid leukemia was assessed in a US cohort of 491,163 persons from the NIH-AARP Diet and Health Study (1995-2003). A total of 338 incident cases of acute myeloid leukemia were ascertained. Multivariate Cox models were utilized to estimate hazard ratios and 95% confidence intervals. Compared with those for never smokers, hazard ratios were 1.29 (95% confidence interval: 0.95, 1.75), 1.79 (95% confidence interval: 1.32, 2.42), 2.42 (95% confidence interval: 1.63, 3.57), and 2.29 (85% confidence interval: 1.38, 3.79) for former smokers who smoked < or =1 or >1 pack/day and for current smokers who smoked < or =1 or >1 pack/day, respectively. Higher meat intake was associated with an increased risk of acute myeloid leukemia (hazard ratio = 1.45, 95% confidence interval: 1.02, 2.07 for the fifth vs. first quintile; P for trend = 0.06); however, there were no clear effects of meat-cooking method or doneness level. Individuals who did not drink coffee appeared to have a higher risk of acute myeloid leukemia than those who drank various quantities of coffee. Neither fruit nor vegetable intake was associated with acute myeloid leukemia. This large prospective study identified smoking and meat intake as risk factors for acute myeloid leukemia. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/20042434/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwp371 DB - PRIME DP - Unbound Medicine ER -