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Diet, lifestyle, and acute myeloid leukemia in the NIH-AARP cohort.

Abstract

The relation between diet, lifestyle, and acute myeloid leukemia was assessed in a US cohort of 491,163 persons from the NIH-AARP Diet and Health Study (1995-2003). A total of 338 incident cases of acute myeloid leukemia were ascertained. Multivariate Cox models were utilized to estimate hazard ratios and 95% confidence intervals. Compared with those for never smokers, hazard ratios were 1.29 (95% confidence interval: 0.95, 1.75), 1.79 (95% confidence interval: 1.32, 2.42), 2.42 (95% confidence interval: 1.63, 3.57), and 2.29 (85% confidence interval: 1.38, 3.79) for former smokers who smoked < or =1 or >1 pack/day and for current smokers who smoked < or =1 or >1 pack/day, respectively. Higher meat intake was associated with an increased risk of acute myeloid leukemia (hazard ratio = 1.45, 95% confidence interval: 1.02, 2.07 for the fifth vs. first quintile; P for trend = 0.06); however, there were no clear effects of meat-cooking method or doneness level. Individuals who did not drink coffee appeared to have a higher risk of acute myeloid leukemia than those who drank various quantities of coffee. Neither fruit nor vegetable intake was associated with acute myeloid leukemia. This large prospective study identified smoking and meat intake as risk factors for acute myeloid leukemia.

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  • Authors+Show Affiliations

    ,

    Division of Chronic Disease Epidemiology, Yale University School of Public Health, New Haven, Connecticut, USA. xiaomei.ma@yale.edu

    , , , , , ,

    Source

    American journal of epidemiology 171:3 2010 Feb 01 pg 312-22

    MeSH

    Alcohol Drinking
    Beverages
    Coffee
    Cohort Studies
    Cooking
    Demography
    Diet
    Drinking
    Female
    Humans
    Leukemia, Myeloid, Acute
    Life Style
    Male
    Meat
    Middle Aged
    National Institutes of Health (U.S.)
    Retirement
    Risk Factors
    Smoking
    Surveys and Questionnaires
    Tea
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    20042434

    Citation

    Ma, Xiaomei, et al. "Diet, Lifestyle, and Acute Myeloid Leukemia in the NIH-AARP Cohort." American Journal of Epidemiology, vol. 171, no. 3, 2010, pp. 312-22.
    Ma X, Park Y, Mayne ST, et al. Diet, lifestyle, and acute myeloid leukemia in the NIH-AARP cohort. Am J Epidemiol. 2010;171(3):312-22.
    Ma, X., Park, Y., Mayne, S. T., Wang, R., Sinha, R., Hollenbeck, A. R., ... Cross, A. J. (2010). Diet, lifestyle, and acute myeloid leukemia in the NIH-AARP cohort. American Journal of Epidemiology, 171(3), pp. 312-22. doi:10.1093/aje/kwp371.
    Ma X, et al. Diet, Lifestyle, and Acute Myeloid Leukemia in the NIH-AARP Cohort. Am J Epidemiol. 2010 Feb 1;171(3):312-22. PubMed PMID: 20042434.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Diet, lifestyle, and acute myeloid leukemia in the NIH-AARP cohort. AU - Ma,Xiaomei, AU - Park,Yikyung, AU - Mayne,Susan T, AU - Wang,Rong, AU - Sinha,Rashmi, AU - Hollenbeck,Albert R, AU - Schatzkin,Arthur, AU - Cross,Amanda J, Y1 - 2009/12/30/ PY - 2010/1/1/entrez PY - 2010/1/1/pubmed PY - 2010/1/30/medline SP - 312 EP - 22 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 171 IS - 3 N2 - The relation between diet, lifestyle, and acute myeloid leukemia was assessed in a US cohort of 491,163 persons from the NIH-AARP Diet and Health Study (1995-2003). A total of 338 incident cases of acute myeloid leukemia were ascertained. Multivariate Cox models were utilized to estimate hazard ratios and 95% confidence intervals. Compared with those for never smokers, hazard ratios were 1.29 (95% confidence interval: 0.95, 1.75), 1.79 (95% confidence interval: 1.32, 2.42), 2.42 (95% confidence interval: 1.63, 3.57), and 2.29 (85% confidence interval: 1.38, 3.79) for former smokers who smoked < or =1 or >1 pack/day and for current smokers who smoked < or =1 or >1 pack/day, respectively. Higher meat intake was associated with an increased risk of acute myeloid leukemia (hazard ratio = 1.45, 95% confidence interval: 1.02, 2.07 for the fifth vs. first quintile; P for trend = 0.06); however, there were no clear effects of meat-cooking method or doneness level. Individuals who did not drink coffee appeared to have a higher risk of acute myeloid leukemia than those who drank various quantities of coffee. Neither fruit nor vegetable intake was associated with acute myeloid leukemia. This large prospective study identified smoking and meat intake as risk factors for acute myeloid leukemia. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/20042434/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwp371 DB - PRIME DP - Unbound Medicine ER -