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Serum folate and homocysteine and depressive symptoms among Japanese men and women.
Eur J Clin Nutr. 2010 Mar; 64(3):289-96.EJ

Abstract

BACKGROUND/OBJECTIVES

Folate and homocysteine have been implicated to have a role in depression. However, results of epidemiologic studies on this issue have been inconsistent. The objective of this study was to clarify the association between serum folate and homocysteine concentrations and depressive symptoms in Japanese adults.

SUBJECTS/METHODS

We analyzed cross-sectional data for 530 municipal employees (313 men and 217 women), aged 21-67 years, who participated in a health survey at the time of periodic checkup. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Logistic regression analysis was used to estimate odds ratios of depressive symptoms (CES-D scale scores of >or=16) with adjustment for potential confounding variables.

RESULTS

In total, 113 men (36.1%) and 79 women (36.4%) had depressive symptoms. A higher serum folate was associated with a decreased prevalence of depressive symptoms in men. The multivariate-adjusted odds ratios (95% confidence interval) of depressive symptoms for the lowest to highest quartiles of serum folate were 1.00 (reference), 0.53 (0.27-1.03), 0.33 (0.16-0.68) and 0.51 (0.25-1.03), respectively (trend P=0.03). Furthermore, the data suggested a positive association between serum homocysteine and depressive symptoms in men (trend P=0.06). In women, neither folate nor homocysteine was associated with depressive symptoms.

CONCLUSIONS

Low serum folate may be related to an increased prevalence of depressive symptoms in Japanese men.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Nanri A
Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Tokyo, Japan. nanri@ri.imcj.go.jp
Mizoue T
No affiliation info available
Matsushita Y
No affiliation info available
Sasaki S
No affiliation info available
Ohta M
No affiliation info available
Sato M
No affiliation info available
Mishima N
No affiliation info available

MeSH

AdultAgedCross-Sectional StudiesDepressionFemaleFolic AcidHealth StatusHealth SurveysHomocysteineHumansJapanLogistic ModelsMaleMiddle AgedMultivariate AnalysisNutritional StatusOdds RatioPrevalenceSex FactorsYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20087384

Citation

Nanri, A, et al. "Serum Folate and Homocysteine and Depressive Symptoms Among Japanese Men and Women." European Journal of Clinical Nutrition, vol. 64, no. 3, 2010, pp. 289-96.
Nanri A, Mizoue T, Matsushita Y, et al. Serum folate and homocysteine and depressive symptoms among Japanese men and women. Eur J Clin Nutr. 2010;64(3):289-96.
Nanri, A., Mizoue, T., Matsushita, Y., Sasaki, S., Ohta, M., Sato, M., & Mishima, N. (2010). Serum folate and homocysteine and depressive symptoms among Japanese men and women. European Journal of Clinical Nutrition, 64(3), 289-96. https://doi.org/10.1038/ejcn.2009.143
Nanri A, et al. Serum Folate and Homocysteine and Depressive Symptoms Among Japanese Men and Women. Eur J Clin Nutr. 2010;64(3):289-96. PubMed PMID: 20087384.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum folate and homocysteine and depressive symptoms among Japanese men and women. AU - Nanri,A, AU - Mizoue,T, AU - Matsushita,Y, AU - Sasaki,S, AU - Ohta,M, AU - Sato,M, AU - Mishima,N, Y1 - 2010/01/20/ PY - 2010/1/21/entrez PY - 2010/1/21/pubmed PY - 2010/5/15/medline SP - 289 EP - 96 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 64 IS - 3 N2 - BACKGROUND/OBJECTIVES: Folate and homocysteine have been implicated to have a role in depression. However, results of epidemiologic studies on this issue have been inconsistent. The objective of this study was to clarify the association between serum folate and homocysteine concentrations and depressive symptoms in Japanese adults. SUBJECTS/METHODS: We analyzed cross-sectional data for 530 municipal employees (313 men and 217 women), aged 21-67 years, who participated in a health survey at the time of periodic checkup. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Logistic regression analysis was used to estimate odds ratios of depressive symptoms (CES-D scale scores of >or=16) with adjustment for potential confounding variables. RESULTS: In total, 113 men (36.1%) and 79 women (36.4%) had depressive symptoms. A higher serum folate was associated with a decreased prevalence of depressive symptoms in men. The multivariate-adjusted odds ratios (95% confidence interval) of depressive symptoms for the lowest to highest quartiles of serum folate were 1.00 (reference), 0.53 (0.27-1.03), 0.33 (0.16-0.68) and 0.51 (0.25-1.03), respectively (trend P=0.03). Furthermore, the data suggested a positive association between serum homocysteine and depressive symptoms in men (trend P=0.06). In women, neither folate nor homocysteine was associated with depressive symptoms. CONCLUSIONS: Low serum folate may be related to an increased prevalence of depressive symptoms in Japanese men. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/20087384/full_citation DB - PRIME DP - Unbound Medicine ER -
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