Type your tag names separated by a space and hit enter

Human breast milk contains bovine IgG. Relationship to infant colic?

Abstract

Previous studies have suggested that an unidentified cow's milk protein, other than beta-lactoglobulin and casein, might play a pathogenetic role in infant colic. Therefore, a radioimmunoassay was used to analyze human breast milk and infant formula samples for the presence of bovine IgG. Milk samples from 88 of the 97 mothers tested contained greater than 0.1 micrograms/mL of bovine IgG. In a study group of 59 mothers with infants in the colic-prone 2- to 17-week age group, the 29 mothers of colicky infants had higher levels of bovine IgG in their breast milk (median 0.42 micrograms/mL) than the 30 mothers of noncolicky infants (median 0.32 micrograms/mL) (P less than .02). The highest concentrations of bovine IgG observed in human milk were 8.5 and 8.2 micrograms/mL. Most cow's milk-based infant formulas contained 0.6 to 6.4 micrograms/mL of bovine IgG, a concentration comparable with levels found in many human milk samples. The results suggest that appreciable quantities of bovine IgG are commonly present in human milk, that significantly higher levels are present in milk from mothers of colicky infants, and that bovine IgG may possibly be involved in the pathogenesis of infant colic.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Washington University School of Medicine, St Louis, Missouri.

    Source

    Pediatrics 87:4 1991 Apr pg 439-44

    MeSH

    Animals
    Cattle
    Colic
    Humans
    Immunoglobulin G
    Infant
    Infant Food
    Infant, Newborn
    Milk
    Milk, Human

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    2011419

    Citation

    Clyne, P S., and A Kulczycki. "Human Breast Milk Contains Bovine IgG. Relationship to Infant Colic?" Pediatrics, vol. 87, no. 4, 1991, pp. 439-44.
    Clyne PS, Kulczycki A. Human breast milk contains bovine IgG. Relationship to infant colic? Pediatrics. 1991;87(4):439-44.
    Clyne, P. S., & Kulczycki, A. (1991). Human breast milk contains bovine IgG. Relationship to infant colic? Pediatrics, 87(4), pp. 439-44.
    Clyne PS, Kulczycki A. Human Breast Milk Contains Bovine IgG. Relationship to Infant Colic. Pediatrics. 1991;87(4):439-44. PubMed PMID: 2011419.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Human breast milk contains bovine IgG. Relationship to infant colic? AU - Clyne,P S, AU - Kulczycki,A,Jr PY - 1991/4/1/pubmed PY - 2001/3/28/medline PY - 1991/4/1/entrez SP - 439 EP - 44 JF - Pediatrics JO - Pediatrics VL - 87 IS - 4 N2 - Previous studies have suggested that an unidentified cow's milk protein, other than beta-lactoglobulin and casein, might play a pathogenetic role in infant colic. Therefore, a radioimmunoassay was used to analyze human breast milk and infant formula samples for the presence of bovine IgG. Milk samples from 88 of the 97 mothers tested contained greater than 0.1 micrograms/mL of bovine IgG. In a study group of 59 mothers with infants in the colic-prone 2- to 17-week age group, the 29 mothers of colicky infants had higher levels of bovine IgG in their breast milk (median 0.42 micrograms/mL) than the 30 mothers of noncolicky infants (median 0.32 micrograms/mL) (P less than .02). The highest concentrations of bovine IgG observed in human milk were 8.5 and 8.2 micrograms/mL. Most cow's milk-based infant formulas contained 0.6 to 6.4 micrograms/mL of bovine IgG, a concentration comparable with levels found in many human milk samples. The results suggest that appreciable quantities of bovine IgG are commonly present in human milk, that significantly higher levels are present in milk from mothers of colicky infants, and that bovine IgG may possibly be involved in the pathogenesis of infant colic. SN - 0031-4005 UR - https://www.unboundmedicine.com/medline/citation/2011419/full_citation L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=2011419 DB - PRIME DP - Unbound Medicine ER -