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Impact of dietary shift to higher-antioxidant foods in COPD: a randomised trial.

Abstract

Chronic obstructive pulmonary disease (COPD) is characterised by increased oxidative stress. Dietary factors, such as ample consumption of foods rich in antioxidants, such as fruit and vegetables, might have beneficial effects in COPD patients. The association between dietary shift to foods rich in antioxidants and lung function in COPD was investigated in a 3-yr prospective study. A total of 120 COPD patients were randomised to follow either a diet based on increased consumption of fresh fruit and vegetables (intervention group (IG)) or a free diet (control group (CG)). The mean consumption of foods containing antioxidants was higher in the IG than in the CG throughout the study period (p<0.05). The relationship between consumption of foods rich in antioxidants and percentage predicted forced expiratory volume in 1 s was assessed using a general linear model for repeated measures; the two groups overall were different in time (p = 0.03), with the IG showing a better outcome. In investigating the effect of several confounders (sex, age, smoking status, comorbid conditions and exacerbation) of group response over time, nonsignificant interactions were found between confounders, group and time. These findings suggest that a dietary shift to higher-antioxidant food intake may be associated with improvement in lung function, and, in this respect, dietary interventions might be considered in COPD management.

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  • Authors+Show Affiliations

    ,

    Dept of Respiratory Medicine, University of Thessaly School of Medicine, Biopolis, 4110 Larissa, Thessaly, Greece.

    , , , , , ,

    Source

    The European respiratory journal 36:4 2010 Oct pg 774-80

    MeSH

    Aged
    Antioxidants
    Diet
    Diet Therapy
    Female
    Fruit
    Humans
    Inflammation
    Male
    Middle Aged
    Prospective Studies
    Pulmonary Disease, Chronic Obstructive
    Spirometry
    Vegetables

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20150206

    Citation

    Keranis, E, et al. "Impact of Dietary Shift to Higher-antioxidant Foods in COPD: a Randomised Trial." The European Respiratory Journal, vol. 36, no. 4, 2010, pp. 774-80.
    Keranis E, Makris D, Rodopoulou P, et al. Impact of dietary shift to higher-antioxidant foods in COPD: a randomised trial. Eur Respir J. 2010;36(4):774-80.
    Keranis, E., Makris, D., Rodopoulou, P., Martinou, H., Papamakarios, G., Daniil, Z., ... Gourgoulianis, K. I. (2010). Impact of dietary shift to higher-antioxidant foods in COPD: a randomised trial. The European Respiratory Journal, 36(4), pp. 774-80. doi:10.1183/09031936.00113809.
    Keranis E, et al. Impact of Dietary Shift to Higher-antioxidant Foods in COPD: a Randomised Trial. Eur Respir J. 2010;36(4):774-80. PubMed PMID: 20150206.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Impact of dietary shift to higher-antioxidant foods in COPD: a randomised trial. AU - Keranis,E, AU - Makris,D, AU - Rodopoulou,P, AU - Martinou,H, AU - Papamakarios,G, AU - Daniil,Z, AU - Zintzaras,E, AU - Gourgoulianis,K I, Y1 - 2010/02/11/ PY - 2010/2/13/entrez PY - 2010/2/13/pubmed PY - 2011/3/11/medline SP - 774 EP - 80 JF - The European respiratory journal JO - Eur. Respir. J. VL - 36 IS - 4 N2 - Chronic obstructive pulmonary disease (COPD) is characterised by increased oxidative stress. Dietary factors, such as ample consumption of foods rich in antioxidants, such as fruit and vegetables, might have beneficial effects in COPD patients. The association between dietary shift to foods rich in antioxidants and lung function in COPD was investigated in a 3-yr prospective study. A total of 120 COPD patients were randomised to follow either a diet based on increased consumption of fresh fruit and vegetables (intervention group (IG)) or a free diet (control group (CG)). The mean consumption of foods containing antioxidants was higher in the IG than in the CG throughout the study period (p<0.05). The relationship between consumption of foods rich in antioxidants and percentage predicted forced expiratory volume in 1 s was assessed using a general linear model for repeated measures; the two groups overall were different in time (p = 0.03), with the IG showing a better outcome. In investigating the effect of several confounders (sex, age, smoking status, comorbid conditions and exacerbation) of group response over time, nonsignificant interactions were found between confounders, group and time. These findings suggest that a dietary shift to higher-antioxidant food intake may be associated with improvement in lung function, and, in this respect, dietary interventions might be considered in COPD management. SN - 1399-3003 UR - https://www.unboundmedicine.com/medline/citation/20150206/full_citation L2 - http://erj.ersjournals.com/cgi/pmidlookup?view=long&amp;pmid=20150206 DB - PRIME DP - Unbound Medicine ER -