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Influence of dietary vitamin K intake on subtherapeutic oral anticoagulant therapy.
Br J Haematol 2010; 149(4):598-605BJ

Abstract

It is unclear what advice should be given to patients using vitamin K antagonists with respect to dietary vitamin K intake. We performed a nested case-control study in patients attending a Dutch anticoagulation clinic, to determine the association between vitamin K intake and subtherapeutic International Normalized Ratio (INR) values and the interaction between usual and recent vitamin K intake. Compared to patients with a normal usual vitamin K intake, those with a high vitamin K intake had a decreased risk of a subtherapeutic INR [Hazard Ratio (HR) 0.80, 95% confidence interval (CI): 0.56-1.16] and patients with a low vitamin K intake an increased risk (HR 1.33, 95% CI: 0.79-2.25). In patients with a low usual vitamin K intake, recent vitamin K intake was twice as high in cases as in controls (164 vs. 85 microg/d). Such a difference was not observed in patients with a normal or high usual vitamin K intake. Our results suggest that a high vitamin K intake reduces the risk of a low INR by lessening the influence of incidental consumption of vitamin K rich food on the INR. These findings support the recommendation for patients on vitamin K antagonists to eat a sufficient amount of vitamin-K containing foods.

Authors+Show Affiliations

Department of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden, The Netherlands.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20151978

Citation

Rombouts, Eva K., et al. "Influence of Dietary Vitamin K Intake On Subtherapeutic Oral Anticoagulant Therapy." British Journal of Haematology, vol. 149, no. 4, 2010, pp. 598-605.
Rombouts EK, Rosendaal FR, van der Meer FJ. Influence of dietary vitamin K intake on subtherapeutic oral anticoagulant therapy. Br J Haematol. 2010;149(4):598-605.
Rombouts, E. K., Rosendaal, F. R., & van der Meer, F. J. (2010). Influence of dietary vitamin K intake on subtherapeutic oral anticoagulant therapy. British Journal of Haematology, 149(4), pp. 598-605. doi:10.1111/j.1365-2141.2010.08108.x.
Rombouts EK, Rosendaal FR, van der Meer FJ. Influence of Dietary Vitamin K Intake On Subtherapeutic Oral Anticoagulant Therapy. Br J Haematol. 2010;149(4):598-605. PubMed PMID: 20151978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of dietary vitamin K intake on subtherapeutic oral anticoagulant therapy. AU - Rombouts,Eva K, AU - Rosendaal,Frits R, AU - van der Meer,Felix J M, Y1 - 2010/02/11/ PY - 2010/2/16/entrez PY - 2010/2/16/pubmed PY - 2010/7/10/medline SP - 598 EP - 605 JF - British journal of haematology JO - Br. J. Haematol. VL - 149 IS - 4 N2 - It is unclear what advice should be given to patients using vitamin K antagonists with respect to dietary vitamin K intake. We performed a nested case-control study in patients attending a Dutch anticoagulation clinic, to determine the association between vitamin K intake and subtherapeutic International Normalized Ratio (INR) values and the interaction between usual and recent vitamin K intake. Compared to patients with a normal usual vitamin K intake, those with a high vitamin K intake had a decreased risk of a subtherapeutic INR [Hazard Ratio (HR) 0.80, 95% confidence interval (CI): 0.56-1.16] and patients with a low vitamin K intake an increased risk (HR 1.33, 95% CI: 0.79-2.25). In patients with a low usual vitamin K intake, recent vitamin K intake was twice as high in cases as in controls (164 vs. 85 microg/d). Such a difference was not observed in patients with a normal or high usual vitamin K intake. Our results suggest that a high vitamin K intake reduces the risk of a low INR by lessening the influence of incidental consumption of vitamin K rich food on the INR. These findings support the recommendation for patients on vitamin K antagonists to eat a sufficient amount of vitamin-K containing foods. SN - 1365-2141 UR - https://www.unboundmedicine.com/medline/citation/20151978/full_citation L2 - https://doi.org/10.1111/j.1365-2141.2010.08108.x DB - PRIME DP - Unbound Medicine ER -