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Iron status is associated with carotid atherosclerotic plaques in middle-aged adults.

Abstract

Although the iron-heart disease hypothesis is prevalent, the epidemiological findings are incongruent. The relationship of serum ferritin with early cardiovascular disease (CVD), particularly atherosclerosis, has not been evaluated extensively, particularly with accounting for inflammation. We examined this association in a case-control study of 124 age- and sex-matched pairs embedded in the population-based random sample (MONICA survey) in Southwest France, taking into account inflammation status. Cases had >or=2 carotid atherosclerotic plaques and controls had none. Inflammation was assessed using several markers, including serum alpha-1 acid glycoprotein (AGP) and high sensitivity C-reactive protein. There was an interaction of inflammation with group (case/control) for serum ferritin. In adults without elevated AGP, serum ferritin was significantly greater in atherosclerotic cases than in adults in the control group. In models adjusted for CVD risk factors, the odds of atherosclerosis increased with the increase in serum ferritin in individuals without elevated AGP; for every 10-microg/L increase in serum ferritin, the risk for atherosclerosis increased by 3% (odds ratio [95% CI]: 1.03 [1.01-1.06]). In conclusion, carotid atherosclerosis was positively associated with serum ferritin in individuals free from subclinical inflammation based on AGP. Further prospective and/or experimental studies are needed to corroborate the observed association of iron status with atherosclerosis.

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  • Authors+Show Affiliations

    ,

    INSERM U558, Department of Epidemiology, Faculty of Medicine, CHU-Toulouse, France. naman123@cict.fr

    , , , , ,

    Source

    The Journal of nutrition 140:4 2010 Apr pg 812-6

    MeSH

    Adult
    Biomarkers
    Carotid Artery Diseases
    Case-Control Studies
    Female
    Ferritins
    Humans
    Iron
    Male
    Middle Aged
    Risk Factors
    Ultrasonography

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20181783

    Citation

    Ahluwalia, Namanjeet, et al. "Iron Status Is Associated With Carotid Atherosclerotic Plaques in Middle-aged Adults." The Journal of Nutrition, vol. 140, no. 4, 2010, pp. 812-6.
    Ahluwalia N, Genoux A, Ferrieres J, et al. Iron status is associated with carotid atherosclerotic plaques in middle-aged adults. J Nutr. 2010;140(4):812-6.
    Ahluwalia, N., Genoux, A., Ferrieres, J., Perret, B., Carayol, M., Drouet, L., & Ruidavets, J. B. (2010). Iron status is associated with carotid atherosclerotic plaques in middle-aged adults. The Journal of Nutrition, 140(4), pp. 812-6. doi:10.3945/jn.109.110353.
    Ahluwalia N, et al. Iron Status Is Associated With Carotid Atherosclerotic Plaques in Middle-aged Adults. J Nutr. 2010;140(4):812-6. PubMed PMID: 20181783.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Iron status is associated with carotid atherosclerotic plaques in middle-aged adults. AU - Ahluwalia,Namanjeet, AU - Genoux,Annelise, AU - Ferrieres,Jean, AU - Perret,Bertrand, AU - Carayol,Marion, AU - Drouet,Ludovic, AU - Ruidavets,Jean-Bernard, Y1 - 2010/02/24/ PY - 2010/2/26/entrez PY - 2010/2/26/pubmed PY - 2010/5/1/medline SP - 812 EP - 6 JF - The Journal of nutrition JO - J. Nutr. VL - 140 IS - 4 N2 - Although the iron-heart disease hypothesis is prevalent, the epidemiological findings are incongruent. The relationship of serum ferritin with early cardiovascular disease (CVD), particularly atherosclerosis, has not been evaluated extensively, particularly with accounting for inflammation. We examined this association in a case-control study of 124 age- and sex-matched pairs embedded in the population-based random sample (MONICA survey) in Southwest France, taking into account inflammation status. Cases had >or=2 carotid atherosclerotic plaques and controls had none. Inflammation was assessed using several markers, including serum alpha-1 acid glycoprotein (AGP) and high sensitivity C-reactive protein. There was an interaction of inflammation with group (case/control) for serum ferritin. In adults without elevated AGP, serum ferritin was significantly greater in atherosclerotic cases than in adults in the control group. In models adjusted for CVD risk factors, the odds of atherosclerosis increased with the increase in serum ferritin in individuals without elevated AGP; for every 10-microg/L increase in serum ferritin, the risk for atherosclerosis increased by 3% (odds ratio [95% CI]: 1.03 [1.01-1.06]). In conclusion, carotid atherosclerosis was positively associated with serum ferritin in individuals free from subclinical inflammation based on AGP. Further prospective and/or experimental studies are needed to corroborate the observed association of iron status with atherosclerosis. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/20181783/full_citation L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.109.110353 DB - PRIME DP - Unbound Medicine ER -