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Associations of diet with albuminuria and kidney function decline.
Clin J Am Soc Nephrol. 2010 May; 5(5):836-43.CJ

Abstract

BACKGROUND AND OBJECTIVES

Sparse longitudinal data exist on how diet influences microalbuminuria and estimated GFR (eGFR) decline in people with well-preserved kidney function.

DESIGN, SETTINGS, PARTICIPANTS, & MEASUREMENTS

Of the 3348 women participating in the Nurses' Health Study who had data on urinary albumin to creatinine ratio in 2000, 3296 also had data on eGFR change between 1989 and 2000. Cumulative average intake of nutrients over 14 years was derived from semiquantitative food frequency questionnaires answered in 1984, 1986, 1990, 1994, and 1998. Microalbuminuria presence and eGFR decline > or = 30% were the outcomes of interest.

RESULTS

Compared with the lowest quartile, the highest quartile of animal fat (odds ratio (OR): 1.72; 95% confidence interval (CI): 1.12 to 2.64) and two or more servings of red meat per week (OR: 1.51; 95% CI: 1.01 to 2.26) were directly associated with microalbuminuria. After adjustment for other nutrients individually associated with eGFR decline > or = 30%, only the highest quartile of sodium intake remained directly associated (OR: 1.52; 95% CI: 1.10 to 2.09), whereas beta-carotene appeared protective (OR: 0.62, 95% CI: 0.43 to 0.89). Results did not vary by diabetes status for microalbuminuria and eGFR outcomes or in those without hypertension at baseline for eGFR decline. No significant associations were seen for other types of protein, fat, vitamins, folate, fructose, or potassium.

CONCLUSIONS

Higher dietary intake of animal fat and two or more servings per week of red meat may increase risk for microalbuminuria. Lower sodium and higher beta-carotene intake may reduce risk for eGFR decline.

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Authors+Show Affiliations

Lin J
Renal Division, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. jlin11@partners.org
Hu FB
No affiliation info available
Curhan GC
No affiliation info available

MeSH

AdultAlbuminuriaChi-Square DistributionDietDiet, Sodium-RestrictedDietary FatsDietary ProteinsDisease ProgressionFeeding BehaviorFemaleGlomerular Filtration RateHealth SurveysHumansKidneyLogistic ModelsMeatMiddle AgedNursesOdds RatioRisk AssessmentRisk FactorsSodium Chloride, DietarySurveys and QuestionnairesTime Factorsbeta Carotene

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20299364

Citation

Lin, Julie, et al. "Associations of Diet With Albuminuria and Kidney Function Decline." Clinical Journal of the American Society of Nephrology : CJASN, vol. 5, no. 5, 2010, pp. 836-43.
Lin J, Hu FB, Curhan GC. Associations of diet with albuminuria and kidney function decline. Clin J Am Soc Nephrol. 2010;5(5):836-43.
Lin, J., Hu, F. B., & Curhan, G. C. (2010). Associations of diet with albuminuria and kidney function decline. Clinical Journal of the American Society of Nephrology : CJASN, 5(5), 836-43. https://doi.org/10.2215/CJN.08001109
Lin J, Hu FB, Curhan GC. Associations of Diet With Albuminuria and Kidney Function Decline. Clin J Am Soc Nephrol. 2010;5(5):836-43. PubMed PMID: 20299364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of diet with albuminuria and kidney function decline. AU - Lin,Julie, AU - Hu,Frank B, AU - Curhan,Gary C, Y1 - 2010/03/18/ PY - 2010/3/20/entrez PY - 2010/3/20/pubmed PY - 2010/8/13/medline SP - 836 EP - 43 JF - Clinical journal of the American Society of Nephrology : CJASN JO - Clin J Am Soc Nephrol VL - 5 IS - 5 N2 - BACKGROUND AND OBJECTIVES: Sparse longitudinal data exist on how diet influences microalbuminuria and estimated GFR (eGFR) decline in people with well-preserved kidney function. DESIGN, SETTINGS, PARTICIPANTS, & MEASUREMENTS: Of the 3348 women participating in the Nurses' Health Study who had data on urinary albumin to creatinine ratio in 2000, 3296 also had data on eGFR change between 1989 and 2000. Cumulative average intake of nutrients over 14 years was derived from semiquantitative food frequency questionnaires answered in 1984, 1986, 1990, 1994, and 1998. Microalbuminuria presence and eGFR decline > or = 30% were the outcomes of interest. RESULTS: Compared with the lowest quartile, the highest quartile of animal fat (odds ratio (OR): 1.72; 95% confidence interval (CI): 1.12 to 2.64) and two or more servings of red meat per week (OR: 1.51; 95% CI: 1.01 to 2.26) were directly associated with microalbuminuria. After adjustment for other nutrients individually associated with eGFR decline > or = 30%, only the highest quartile of sodium intake remained directly associated (OR: 1.52; 95% CI: 1.10 to 2.09), whereas beta-carotene appeared protective (OR: 0.62, 95% CI: 0.43 to 0.89). Results did not vary by diabetes status for microalbuminuria and eGFR outcomes or in those without hypertension at baseline for eGFR decline. No significant associations were seen for other types of protein, fat, vitamins, folate, fructose, or potassium. CONCLUSIONS: Higher dietary intake of animal fat and two or more servings per week of red meat may increase risk for microalbuminuria. Lower sodium and higher beta-carotene intake may reduce risk for eGFR decline. SN - 1555-905X UR - https://www.unboundmedicine.com/medline/citation/20299364/full_citation L2 - https://cjasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=20299364 DB - PRIME DP - Unbound Medicine ER -