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Consumption of meat and dairy and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition.

Abstract

The consumption of meat and other foods of animal origin is a risk factor for several types of cancer, but the results for lymphomas are inconclusive. Therefore, we examined these associations among 411,097 participants of the European Prospective Investigation into Cancer and Nutrition. During a median follow-up of 8.5 years, 1,334 lymphomas (1,267 non-Hodgkin lymphoma (NHL) and 67 Hodgkin lymphomas) were identified. Consumption of red and processed meat, poultry, milk and dairy products was assessed by dietary questionnaires. Cox proportional hazard regression was used to evaluate the association of the consumption of these food groups with lymphoma risk. Overall, the consumption of foods of animal origin was not associated with an increased risk of NHLS or HL, but the associations with specific subgroups of NHL entities were noted. A high intake of processed meat was associated with an increased risk of B-cell chronic lymphocytic leukemia (BCLL) [relative risk (RR) per 50 g intake = 1.31, 95% confidence interval (CI) 1.06-1.63], but a decreased risk of follicular lymphomas (FL) (RR = 0.58; CI 0.38-0.89). A high intake of poultry was related to an increased risk of B-cell lymphomas (RR = 1.22; CI 1.05-1.42 per 10 g intake), FL (RR = 1.65; CI 1.18-2.32) and BCLL (RR = 1.54; CI 1.18-2.01) in the continuous models. In conclusion, no consistent associations between red and processed meat consumption and lymphoma risk were observed, but we found that the consumption of poultry was related to an increased risk of B-cell lymphomas. Chance is a plausible explanation of the observed associations, which need to be confirmed in further studies.

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  • Authors+Show Affiliations

    ,

    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany. sabine.rohrmann@ifspm.uzh.ch

    , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

    Source

    International journal of cancer 128:3 2011 Feb 01 pg 623-34

    MeSH

    Cheese
    Cohort Studies
    Dairy Products
    Europe
    Female
    Humans
    Lymphoma
    Lymphoma, B-Cell
    Lymphoma, Non-Hodgkin
    Lymphoma, T-Cell
    Male
    Meat
    Risk Assessment
    Waldenstrom Macroglobulinemia
    Yogurt

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20473877

    Citation

    Rohrmann, Sabine, et al. "Consumption of Meat and Dairy and Lymphoma Risk in the European Prospective Investigation Into Cancer and Nutrition." International Journal of Cancer, vol. 128, no. 3, 2011, pp. 623-34.
    Rohrmann S, Linseisen J, Jakobsen MU, et al. Consumption of meat and dairy and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer. 2011;128(3):623-34.
    Rohrmann, S., Linseisen, J., Jakobsen, M. U., Overvad, K., Raaschou-Nielsen, O., Tjonneland, A., ... Vineis, P. (2011). Consumption of meat and dairy and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 128(3), pp. 623-34. doi:10.1002/ijc.25387.
    Rohrmann S, et al. Consumption of Meat and Dairy and Lymphoma Risk in the European Prospective Investigation Into Cancer and Nutrition. Int J Cancer. 2011 Feb 1;128(3):623-34. PubMed PMID: 20473877.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Consumption of meat and dairy and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition. AU - Rohrmann,Sabine, AU - Linseisen,Jakob, AU - Jakobsen,Marianne Uhre, AU - Overvad,Kim, AU - Raaschou-Nielsen,Ole, AU - Tjonneland,Anne, AU - Boutron-Ruault,Marie Christine, AU - Kaaks,Rudolf, AU - Becker,Nikolaus, AU - Bergmann,Manuela, AU - Boeing,Heiner, AU - Khaw,Kay-Tee, AU - Wareham,Nicholas J, AU - Key,Timothy J, AU - Travis,Ruth, AU - Benetou,Vassiliki, AU - Naska,Androniki, AU - Trichopoulou,Antonia, AU - Pala,Valeria, AU - Tumino,Rosario, AU - Masala,Giovanna, AU - Mattiello,Amalia, AU - Brustad,Magritt, AU - Lund,Eiliv, AU - Skeie,Guri, AU - Bueno-de-Mesquita,H Bas, AU - Peeters,Petra H M, AU - Vermeulen,Roel C H, AU - Jakszyn,Paula, AU - Dorronsoro,Miren, AU - Barricarte,Aurelio, AU - Tormo,Maria-Jose, AU - Molina,Esther, AU - Argüelles,Marcial, AU - Melin,Beatrice, AU - Ericson,Ulrika, AU - Manjer,Jonas, AU - Rinaldi,Sabina, AU - Slimani,Nadia, AU - Boffetta,Paolo, AU - Vergnaud,Anne-Claire, AU - Khan,Aneire, AU - Norat,Teresa, AU - Vineis,Paolo, PY - 2010/5/18/entrez PY - 2010/5/18/pubmed PY - 2011/1/15/medline SP - 623 EP - 34 JF - International journal of cancer JO - Int. J. Cancer VL - 128 IS - 3 N2 - The consumption of meat and other foods of animal origin is a risk factor for several types of cancer, but the results for lymphomas are inconclusive. Therefore, we examined these associations among 411,097 participants of the European Prospective Investigation into Cancer and Nutrition. During a median follow-up of 8.5 years, 1,334 lymphomas (1,267 non-Hodgkin lymphoma (NHL) and 67 Hodgkin lymphomas) were identified. Consumption of red and processed meat, poultry, milk and dairy products was assessed by dietary questionnaires. Cox proportional hazard regression was used to evaluate the association of the consumption of these food groups with lymphoma risk. Overall, the consumption of foods of animal origin was not associated with an increased risk of NHLS or HL, but the associations with specific subgroups of NHL entities were noted. A high intake of processed meat was associated with an increased risk of B-cell chronic lymphocytic leukemia (BCLL) [relative risk (RR) per 50 g intake = 1.31, 95% confidence interval (CI) 1.06-1.63], but a decreased risk of follicular lymphomas (FL) (RR = 0.58; CI 0.38-0.89). A high intake of poultry was related to an increased risk of B-cell lymphomas (RR = 1.22; CI 1.05-1.42 per 10 g intake), FL (RR = 1.65; CI 1.18-2.32) and BCLL (RR = 1.54; CI 1.18-2.01) in the continuous models. In conclusion, no consistent associations between red and processed meat consumption and lymphoma risk were observed, but we found that the consumption of poultry was related to an increased risk of B-cell lymphomas. Chance is a plausible explanation of the observed associations, which need to be confirmed in further studies. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/20473877/full_citation L2 - https://doi.org/10.1002/ijc.25387 DB - PRIME DP - Unbound Medicine ER -