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Intake of fruits and vegetables, and risk of endometrial cancer in the NIH-AARP Diet and Health Study.

Abstract

BACKGROUND

Fruits and vegetables contain a wide variety of phytochemicals which may have anti-carcinogenic effects. Although the results of case-control studies have suggested a possible protective effect of fruit and vegetable intake on the risk of endometrial carcinoma, few cohort studies have examined this association.

MATERIALS AND METHODS

We used data from the NIH-AARP Diet and Health Study to assess the association of fruit and vegetable consumption, as well as intake of specific botanical groupings of fruits and vegetables, with endometrial cancer risk among 112,088 women who completed a food-frequency questionnaire at baseline, in 1995-1996. During 8 years of follow-up 1142 incident cases of endometrial cancer were ascertained. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI).

RESULTS

After adjustment for covariates, HRs for the highest compared to the lowest quintile of total fruit and total vegetable intake were 1.30 (95% CI 1.04-1.61, P for trend 0.05) and 1.09 (95% CI 0.90-1.33, P for trend 0.55), respectively. No inverse associations were observed for intake of any of 13 botanical groupings of fruits and vegetables.

CONCLUSIONS

Results from this large prospective study do not support a protective role of a high intake of fruits or vegetables on the risk of endometrial cancer in older women.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. Geoffrey.kabat@einstein.yu.edu

    , , ,

    Source

    Cancer epidemiology 34:5 2010 Oct pg 568-73

    MeSH

    Aged
    Cohort Studies
    Diet
    Endometrial Neoplasms
    Female
    Fruit
    Humans
    Middle Aged
    National Institutes of Health (U.S.)
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires
    United States
    Vegetables

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    20619761

    Citation

    Kabat, Geoffrey C., et al. "Intake of Fruits and Vegetables, and Risk of Endometrial Cancer in the NIH-AARP Diet and Health Study." Cancer Epidemiology, vol. 34, no. 5, 2010, pp. 568-73.
    Kabat GC, Park Y, Hollenbeck AR, et al. Intake of fruits and vegetables, and risk of endometrial cancer in the NIH-AARP Diet and Health Study. Cancer Epidemiol. 2010;34(5):568-73.
    Kabat, G. C., Park, Y., Hollenbeck, A. R., Schatzkin, A., & Rohan, T. E. (2010). Intake of fruits and vegetables, and risk of endometrial cancer in the NIH-AARP Diet and Health Study. Cancer Epidemiology, 34(5), pp. 568-73. doi:10.1016/j.canep.2010.06.005.
    Kabat GC, et al. Intake of Fruits and Vegetables, and Risk of Endometrial Cancer in the NIH-AARP Diet and Health Study. Cancer Epidemiol. 2010;34(5):568-73. PubMed PMID: 20619761.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intake of fruits and vegetables, and risk of endometrial cancer in the NIH-AARP Diet and Health Study. AU - Kabat,Geoffrey C, AU - Park,Yikyung, AU - Hollenbeck,Albert R, AU - Schatzkin,Arthur, AU - Rohan,Thomas E, Y1 - 2010/07/08/ PY - 2010/03/30/received PY - 2010/06/10/revised PY - 2010/06/13/accepted PY - 2010/7/13/entrez PY - 2010/7/14/pubmed PY - 2010/12/14/medline SP - 568 EP - 73 JF - Cancer epidemiology JO - Cancer Epidemiol VL - 34 IS - 5 N2 - BACKGROUND: Fruits and vegetables contain a wide variety of phytochemicals which may have anti-carcinogenic effects. Although the results of case-control studies have suggested a possible protective effect of fruit and vegetable intake on the risk of endometrial carcinoma, few cohort studies have examined this association. MATERIALS AND METHODS: We used data from the NIH-AARP Diet and Health Study to assess the association of fruit and vegetable consumption, as well as intake of specific botanical groupings of fruits and vegetables, with endometrial cancer risk among 112,088 women who completed a food-frequency questionnaire at baseline, in 1995-1996. During 8 years of follow-up 1142 incident cases of endometrial cancer were ascertained. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). RESULTS: After adjustment for covariates, HRs for the highest compared to the lowest quintile of total fruit and total vegetable intake were 1.30 (95% CI 1.04-1.61, P for trend 0.05) and 1.09 (95% CI 0.90-1.33, P for trend 0.55), respectively. No inverse associations were observed for intake of any of 13 botanical groupings of fruits and vegetables. CONCLUSIONS: Results from this large prospective study do not support a protective role of a high intake of fruits or vegetables on the risk of endometrial cancer in older women. SN - 1877-783X UR - https://www.unboundmedicine.com/medline/citation/20619761/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1877-7821(10)00111-6 DB - PRIME DP - Unbound Medicine ER -