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Alcohol and tobacco use in relation to gastric cancer: a prospective study of men in Shanghai, China.

Abstract

BACKGROUND

Epidemiologic findings of tobacco and alcohol use in relation to gastric cancer are inconsistent. Well-designed prospective studies examining their relationship are sparse.

METHODS

The association between cigarette smoking/alcohol intake and gastric cancer risk was examined in a population-based prospective cohort of 18,244 middle-aged and older men in Shanghai, China, who were enrolled in the study during 1986-1989. After up to 20 years of follow-up, 391 incident gastric cancer cases were identified. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and corresponding 95% confidence intervals (95% CI).

RESULTS

Ever smokers experienced a statistically significant increased risk of gastric cancer (HR, 1.59; 95% CI, 1.27-1.99) compared with nonsmokers after adjustment for alcohol intake and other confounders. Among nondrinkers, smokers experienced 80% increased risk of gastric cancer (HR, 1.81; 95% CI,1.36, 2.41). Conversely, heavy drinkers experienced a statistically significant increase in risk of gastric cancer (HR, 1.46; 95% CI, 1.05-2.04) among all subjects and a statistically nonsignificant 80% increased risk among never smokers. Further adjustment for Helicobacter pylori serology, serum levels of beta-carotene and vitamin C, and urinary level of total isothiocyanates in combination with glutathione S-transferase (GST) M1 and GSTT1 genotypes did not materially change the associations between smoking/alcohol consumption and gastric cancer risk.

CONCLUSIONS

These results suggest that cigarette smoking and alcohol consumption may exert independent effects on the development of gastric cancer in this high-risk population.

IMPACT

Modification of these lifestyle choices may reduce the incidence of gastric cancer.

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  • Authors+Show Affiliations

    ,

    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Masonic Cancer Center, Minneapolis, Minnesota 55455, USA. moyx0022@umn.edu

    , , , ,

    Source

    MeSH

    Alcohol Drinking
    Body Mass Index
    China
    Cohort Studies
    Follow-Up Studies
    Humans
    Incidence
    Male
    Middle Aged
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Smoking
    Stomach Neoplasms

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    20699372

    Citation

    Moy, Kristin A., et al. "Alcohol and Tobacco Use in Relation to Gastric Cancer: a Prospective Study of Men in Shanghai, China." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 19, no. 9, 2010, pp. 2287-97.
    Moy KA, Fan Y, Wang R, et al. Alcohol and tobacco use in relation to gastric cancer: a prospective study of men in Shanghai, China. Cancer Epidemiol Biomarkers Prev. 2010;19(9):2287-97.
    Moy, K. A., Fan, Y., Wang, R., Gao, Y. T., Yu, M. C., & Yuan, J. M. (2010). Alcohol and tobacco use in relation to gastric cancer: a prospective study of men in Shanghai, China. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 19(9), pp. 2287-97. doi:10.1158/1055-9965.EPI-10-0362.
    Moy KA, et al. Alcohol and Tobacco Use in Relation to Gastric Cancer: a Prospective Study of Men in Shanghai, China. Cancer Epidemiol Biomarkers Prev. 2010;19(9):2287-97. PubMed PMID: 20699372.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol and tobacco use in relation to gastric cancer: a prospective study of men in Shanghai, China. AU - Moy,Kristin A, AU - Fan,Yunhua, AU - Wang,Renwei, AU - Gao,Yu-Tang, AU - Yu,Mimi C, AU - Yuan,Jian-Min, Y1 - 2010/08/10/ PY - 2010/8/12/entrez PY - 2010/8/12/pubmed PY - 2011/2/9/medline SP - 2287 EP - 97 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 19 IS - 9 N2 - BACKGROUND: Epidemiologic findings of tobacco and alcohol use in relation to gastric cancer are inconsistent. Well-designed prospective studies examining their relationship are sparse. METHODS: The association between cigarette smoking/alcohol intake and gastric cancer risk was examined in a population-based prospective cohort of 18,244 middle-aged and older men in Shanghai, China, who were enrolled in the study during 1986-1989. After up to 20 years of follow-up, 391 incident gastric cancer cases were identified. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and corresponding 95% confidence intervals (95% CI). RESULTS: Ever smokers experienced a statistically significant increased risk of gastric cancer (HR, 1.59; 95% CI, 1.27-1.99) compared with nonsmokers after adjustment for alcohol intake and other confounders. Among nondrinkers, smokers experienced 80% increased risk of gastric cancer (HR, 1.81; 95% CI,1.36, 2.41). Conversely, heavy drinkers experienced a statistically significant increase in risk of gastric cancer (HR, 1.46; 95% CI, 1.05-2.04) among all subjects and a statistically nonsignificant 80% increased risk among never smokers. Further adjustment for Helicobacter pylori serology, serum levels of beta-carotene and vitamin C, and urinary level of total isothiocyanates in combination with glutathione S-transferase (GST) M1 and GSTT1 genotypes did not materially change the associations between smoking/alcohol consumption and gastric cancer risk. CONCLUSIONS: These results suggest that cigarette smoking and alcohol consumption may exert independent effects on the development of gastric cancer in this high-risk population. IMPACT: Modification of these lifestyle choices may reduce the incidence of gastric cancer. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/20699372/full_citation L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=20699372 DB - PRIME DP - Unbound Medicine ER -