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Individual saturated fatty acids are associated with different components of insulin resistance and glucose metabolism: the GOCADAN study.
Int J Circumpolar Health 2010; 69(4):344-51IJ

Abstract

OBJECTIVES

Type 2 diabetes and the consumption of saturated fatty acids (FAs) are on the rise among Alaska Inuits. This analysis, based on a cross-sectional study, explores the possible associations of saturated FA content in red blood cells (RBCs) and parameters of glucose metabolism in a sample of Alaska Natives.

STUDY DESIGN AND METHODS

The sample included 343 women and 282 men aged 35-74. Statistical analyses explored the associations of selected RBC (myristic, palmitic and stearic acids) FAs with fasting glucose (plasma), fasting insulin (plasma), 2h glucose (2-hour glucose tolerance test), 2h insulin and homeostasis model assessment (HOMA) index. The models included sex and glucose metabolism status as fixed factors and age, body mass index (BMI), waist circumference, physical activity (METS) and FA content in RBCs as covariates. Measures of insulin, glucose and HOMA index were used as dependent variables.

RESULTS

Myristic acid was positively associated with fasting insulin (β=0.47, p<0.001), 2h insulin (β=0.53, p=0.02) and HOMA index (β=0.455, p<0.001). Palmitic acid was associated with 2h glucose (β=2.3×10(-2), p<0.001) and 2h insulin (β=5.6×10(-2), p=0.002) and stearic acid was associated with fasting glucose (β=4.8×10(-3), p=0.006).

CONCLUSIONS

These results strongly support the hypothesis that saturated fatty acids are associated with insulin resistance and glucose intolerance and that saturated fatty acids are significant risk factors for type 2 diabetes.

Authors+Show Affiliations

GOCADAN Department, Norton Sound Health Corporation, Nome, Alaska 99762, USA. soebbesson@alaska.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20719107

Citation

Ebbesson, Sven O E., et al. "Individual Saturated Fatty Acids Are Associated With Different Components of Insulin Resistance and Glucose Metabolism: the GOCADAN Study." International Journal of Circumpolar Health, vol. 69, no. 4, 2010, pp. 344-51.
Ebbesson SO, Tejero ME, López-Alvarenga JC, et al. Individual saturated fatty acids are associated with different components of insulin resistance and glucose metabolism: the GOCADAN study. Int J Circumpolar Health. 2010;69(4):344-51.
Ebbesson, S. O., Tejero, M. E., López-Alvarenga, J. C., Harris, W. S., Ebbesson, L. O., Devereux, R. B., ... Comuzzie, A. G. (2010). Individual saturated fatty acids are associated with different components of insulin resistance and glucose metabolism: the GOCADAN study. International Journal of Circumpolar Health, 69(4), pp. 344-51.
Ebbesson SO, et al. Individual Saturated Fatty Acids Are Associated With Different Components of Insulin Resistance and Glucose Metabolism: the GOCADAN Study. Int J Circumpolar Health. 2010;69(4):344-51. PubMed PMID: 20719107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Individual saturated fatty acids are associated with different components of insulin resistance and glucose metabolism: the GOCADAN study. AU - Ebbesson,Sven O E, AU - Tejero,M Elizabeth, AU - López-Alvarenga,Juan Carlos, AU - Harris,William S, AU - Ebbesson,Lars O E, AU - Devereux,Richard B, AU - MacCluer,Jean W, AU - Wenger,Charlotte, AU - Laston,Sandra, AU - Fabsitz,Richard R, AU - Howard,Barbara V, AU - Comuzzie,Anthony G, Y1 - 2010/08/18/ PY - 2010/8/20/entrez PY - 2010/8/20/pubmed PY - 2011/2/2/medline SP - 344 EP - 51 JF - International journal of circumpolar health JO - Int J Circumpolar Health VL - 69 IS - 4 N2 - OBJECTIVES: Type 2 diabetes and the consumption of saturated fatty acids (FAs) are on the rise among Alaska Inuits. This analysis, based on a cross-sectional study, explores the possible associations of saturated FA content in red blood cells (RBCs) and parameters of glucose metabolism in a sample of Alaska Natives. STUDY DESIGN AND METHODS: The sample included 343 women and 282 men aged 35-74. Statistical analyses explored the associations of selected RBC (myristic, palmitic and stearic acids) FAs with fasting glucose (plasma), fasting insulin (plasma), 2h glucose (2-hour glucose tolerance test), 2h insulin and homeostasis model assessment (HOMA) index. The models included sex and glucose metabolism status as fixed factors and age, body mass index (BMI), waist circumference, physical activity (METS) and FA content in RBCs as covariates. Measures of insulin, glucose and HOMA index were used as dependent variables. RESULTS: Myristic acid was positively associated with fasting insulin (β=0.47, p<0.001), 2h insulin (β=0.53, p=0.02) and HOMA index (β=0.455, p<0.001). Palmitic acid was associated with 2h glucose (β=2.3×10(-2), p<0.001) and 2h insulin (β=5.6×10(-2), p=0.002) and stearic acid was associated with fasting glucose (β=4.8×10(-3), p=0.006). CONCLUSIONS: These results strongly support the hypothesis that saturated fatty acids are associated with insulin resistance and glucose intolerance and that saturated fatty acids are significant risk factors for type 2 diabetes. SN - 2242-3982 UR - https://www.unboundmedicine.com/medline/citation/20719107/full_citation L2 - http://www.tandfonline.com/doi/full/10.3402/ijch.v69i4.17669 DB - PRIME DP - Unbound Medicine ER -