TY - JOUR T1 - Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study. AU - González,Carlos A, AU - Travier,Noemie, AU - Luján-Barroso,Leila, AU - Castellsagué,Xavier, AU - Bosch,F Xavier, AU - Roura,Esther, AU - Bueno-de-Mesquita,H Bas, AU - Palli,Domenico, AU - Boeing,Heiner, AU - Pala,Valeria, AU - Sacerdote,Carlotta, AU - Tumino,Rosario, AU - Panico,Salvatore, AU - Manjer,Jonas, AU - Dillner,Joakim, AU - Hallmans,Göran, AU - Kjellberg,Lennart, AU - Sanchez,María-José, AU - Altzibar,Jone M, AU - Barricarte,Aurelio, AU - Navarro,Carmen, AU - Rodriguez,Laudina, AU - Allen,Naomi, AU - Key,Timothy J, AU - Kaaks,Rudolf, AU - Rohrmann,Sabine, AU - Overvad,Kim, AU - Olsen,Anja, AU - Tjønneland,Anne, AU - Munk,Christian, AU - Kjaer,Susanne Krüger, AU - Peeters,Petra H M, AU - van Duijnhoven,Fränzel J B, AU - Clavel-Chapelon,Françoise, AU - Boutron-Ruault,Marie-Christine, AU - Trichopoulou,Antonia, AU - Benetou,Vasiliki, AU - Naska,Androniki, AU - Lund,Eiliv, AU - Engeset,Dagrun, AU - Skeie,Guri, AU - Franceschi,Silvia, AU - Slimani,Nadia, AU - Rinaldi,Sabina, AU - Riboli,Elio, Y1 - 2010/11/18/ PY - 2010/03/03/received PY - 2010/06/10/accepted PY - 2010/9/21/entrez PY - 2010/9/21/pubmed PY - 2011/8/5/medline SP - 449 EP - 59 JF - International journal of cancer JO - Int J Cancer VL - 129 IS - 2 N2 - Some dietary factors could be involved as cofactors in cervical carcinogenesis, but evidence is inconclusive. There are no data about the effect of fruits and vegetables intake (F&V) on cervical cancer from cohort studies. We examined the association between the intake of F&V and selected nutrients and the incidence of carcinoma in situ (CIS) and invasive squamous cervical cancer (ISC) in a prospective study of 299,649 women, participating in the European Prospective Investigation into Cancer and Nutrition study. Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CI). A calibration study was used to control measurement errors in the dietary questionnaire. After a mean of 9 years of follow-up, 253 ISC and 817 CIS cases were diagnosed. In the calibrated model, we observed a statistically significant inverse association of ISC with a daily increase in intake of 100 g of total fruits (HR 0.83; 95% CI 0.72-0.98) and a statistically nonsignificant inverse association with a daily increase in intake of 100 g of total vegetables (HR 0.85: 95% CI 0.65-1.10). Statistically nonsignificant inverse associations were also observed for leafy vegetables, root vegetables, garlic and onions, citrus fruits, vitamin C, vitamin E and retinol for ISC. No association was found regarding beta-carotene, vitamin D and folic acid for ISC. None of the dietary factors examined was associated with CIS. Our study suggests a possible protective role of fruit intake and other dietary factors on ISC that need to be confirmed on a larger number of ISC cases. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/20853322/full_citation L2 - https://doi.org/10.1002/ijc.25679 DB - PRIME DP - Unbound Medicine ER -