Tags

Type your tag names separated by a space and hit enter

Dietary factors and risk of chronic lymphocytic leukemia and small lymphocytic lymphoma: a pooled analysis of two prospective studies.

Abstract

BACKGROUND

Other than male sex, family history, advanced age, and race, risk factors for chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) are unknown. Very few studies have investigated diet in relation to these leukemias, and no consistent associations are known.

METHODS

Using two large prospective population-based studies, we evaluated the relationship between diet and CLL/SLL risk. Among 525,982 men and women free of cancer at enrollment, we identified 1,129 incident CLL/SLL cases during 11.2 years of follow-up.

RESULTS

We found no associations between total fat, saturated fat, fiber, red meat, processed meat, fruit, or vegetable intake and risk of CLL/SLL. We noted a suggestive positive association between body mass index and CLL/SLL (hazard ratio, 1.30; 95% confidence interval, 0.99-1.36).

CONCLUSION

We did not find any associations between food or nutrient intake and CLL/SLL.

IMPACT

Our large prospective study indicates that diet may not play a role in CLL/SLL development.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892, USA.

    , , , ,

    Source

    MeSH

    Aged
    Aged, 80 and over
    Cohort Studies
    Diet
    Female
    Humans
    Leukemia, Lymphocytic, Chronic, B-Cell
    Male
    Middle Aged
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    20929883

    Citation

    Tsai, Huei-Ting, et al. "Dietary Factors and Risk of Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: a Pooled Analysis of Two Prospective Studies." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 19, no. 10, 2010, pp. 2680-4.
    Tsai HT, Cross AJ, Graubard BI, et al. Dietary factors and risk of chronic lymphocytic leukemia and small lymphocytic lymphoma: a pooled analysis of two prospective studies. Cancer Epidemiol Biomarkers Prev. 2010;19(10):2680-4.
    Tsai, H. T., Cross, A. J., Graubard, B. I., Oken, M., Schatzkin, A., & Caporaso, N. E. (2010). Dietary factors and risk of chronic lymphocytic leukemia and small lymphocytic lymphoma: a pooled analysis of two prospective studies. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 19(10), pp. 2680-4. doi:10.1158/1055-9965.EPI-10-0585.
    Tsai HT, et al. Dietary Factors and Risk of Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: a Pooled Analysis of Two Prospective Studies. Cancer Epidemiol Biomarkers Prev. 2010;19(10):2680-4. PubMed PMID: 20929883.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary factors and risk of chronic lymphocytic leukemia and small lymphocytic lymphoma: a pooled analysis of two prospective studies. AU - Tsai,Huei-Ting, AU - Cross,Amanda J, AU - Graubard,Barry I, AU - Oken,Martin, AU - Schatzkin,Arthur, AU - Caporaso,Neil E, PY - 2010/10/9/entrez PY - 2010/10/12/pubmed PY - 2011/2/23/medline SP - 2680 EP - 4 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 19 IS - 10 N2 - BACKGROUND: Other than male sex, family history, advanced age, and race, risk factors for chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) are unknown. Very few studies have investigated diet in relation to these leukemias, and no consistent associations are known. METHODS: Using two large prospective population-based studies, we evaluated the relationship between diet and CLL/SLL risk. Among 525,982 men and women free of cancer at enrollment, we identified 1,129 incident CLL/SLL cases during 11.2 years of follow-up. RESULTS: We found no associations between total fat, saturated fat, fiber, red meat, processed meat, fruit, or vegetable intake and risk of CLL/SLL. We noted a suggestive positive association between body mass index and CLL/SLL (hazard ratio, 1.30; 95% confidence interval, 0.99-1.36). CONCLUSION: We did not find any associations between food or nutrient intake and CLL/SLL. IMPACT: Our large prospective study indicates that diet may not play a role in CLL/SLL development. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/20929883/full_citation L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=20929883 DB - PRIME DP - Unbound Medicine ER -