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Small intestinal bacterial overgrowth.

Abstract

Despite the current increase in interest in the role of the microbiota in health and disease and the recognition, for over 50 years, that an excess of colonic-type flora in the small intestine could lead to a malabsorption syndrome, small intestinal overgrowth remains poorly defined. This lack of clarity owes much to the difficulties that arise in attempting to arrive at consensus with regard to the diagnosis of this condition: there is currently no gold standard and the commonly available methodologies (the culture of jejunal aspirates and a variety of breath tests) suffer from considerable variations in their performance and interpretation, leading to variations in the prevalence of overgrowth in a variety of clinical contexts. Treatment is similarly supported by a scant evidence base and the most commonly used antibiotic regimens owe more to custom than clinical trials.

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  • Authors+Show Affiliations

    ,

    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. e.quigley@ucc.ie

    Source

    Infectious disease clinics of North America 24:4 2010 Dec pg 943-59, viii-ix

    MeSH

    Anti-Bacterial Agents
    Bacteria
    Bacterial Infections
    Breath Tests
    Colony Count, Microbial
    Humans
    Intestinal Diseases
    Intestine, Small
    Malabsorption Syndromes
    Prevalence

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    20937459

    Citation

    Quigley, Eamonn M M., and Ahmed Abu-Shanab. "Small Intestinal Bacterial Overgrowth." Infectious Disease Clinics of North America, vol. 24, no. 4, 2010, pp. 943-59, viii-ix.
    Quigley EM, Abu-Shanab A. Small intestinal bacterial overgrowth. Infect Dis Clin North Am. 2010;24(4):943-59, viii-ix.
    Quigley, E. M., & Abu-Shanab, A. (2010). Small intestinal bacterial overgrowth. Infectious Disease Clinics of North America, 24(4), pp. 943-59, viii-ix. doi:10.1016/j.idc.2010.07.007.
    Quigley EM, Abu-Shanab A. Small Intestinal Bacterial Overgrowth. Infect Dis Clin North Am. 2010;24(4):943-59, viii-ix. PubMed PMID: 20937459.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Small intestinal bacterial overgrowth. AU - Quigley,Eamonn M M, AU - Abu-Shanab,Ahmed, PY - 2010/10/13/entrez PY - 2010/10/13/pubmed PY - 2011/2/25/medline SP - 943-59, viii-ix JF - Infectious disease clinics of North America JO - Infect. Dis. Clin. North Am. VL - 24 IS - 4 N2 - Despite the current increase in interest in the role of the microbiota in health and disease and the recognition, for over 50 years, that an excess of colonic-type flora in the small intestine could lead to a malabsorption syndrome, small intestinal overgrowth remains poorly defined. This lack of clarity owes much to the difficulties that arise in attempting to arrive at consensus with regard to the diagnosis of this condition: there is currently no gold standard and the commonly available methodologies (the culture of jejunal aspirates and a variety of breath tests) suffer from considerable variations in their performance and interpretation, leading to variations in the prevalence of overgrowth in a variety of clinical contexts. Treatment is similarly supported by a scant evidence base and the most commonly used antibiotic regimens owe more to custom than clinical trials. SN - 1557-9824 UR - https://www.unboundmedicine.com/medline/citation/20937459/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0891-5520(10)00062-0 DB - PRIME DP - Unbound Medicine ER -