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Anti-inflammatory nutrition as a pharmacological approach to treat obesity.

Abstract

Obesity is a multifactorial condition resulting from improper balances of hormones and gene expression induced by the diet. Obesity also has a strong inflammatory component that can be driven by diet-induced increases in arachidonic acid. The purpose of this paper is to discuss the molecular targets that can be addressed by anti-inflammatory nutrition. These molecular targets range from reduction of proinflammatory eicosanoids to the modulation of features of the innate immune system, such as toll-like receptors and gene transcription factors. From knowledge of the impact of these dietary nutrients on these various molecular targets, it becomes possible to develop a general outline of an anti-inflammatory diet that can offer a unique synergism with more traditional pharmacological approaches in treating obesity and its associated comorbidities.

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  • Authors+Show Affiliations

    ,

    Inflammation Research Foundation, Marblehead, MA 01945, USA.

    Source

    Journal of obesity 2011: 2011 pg

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    20953366

    Citation

    Sears, Barry, and Camillo Ricordi. "Anti-inflammatory Nutrition as a Pharmacological Approach to Treat Obesity." Journal of Obesity, vol. 2011, 2011.
    Sears B, Ricordi C. Anti-inflammatory nutrition as a pharmacological approach to treat obesity. J Obes. 2011;2011.
    Sears, B., & Ricordi, C. (2011). Anti-inflammatory nutrition as a pharmacological approach to treat obesity. Journal of Obesity, 2011, doi:10.1155/2011/431985.
    Sears B, Ricordi C. Anti-inflammatory Nutrition as a Pharmacological Approach to Treat Obesity. J Obes. 2011;2011 PubMed PMID: 20953366.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Anti-inflammatory nutrition as a pharmacological approach to treat obesity. AU - Sears,Barry, AU - Ricordi,Camillo, Y1 - 2010/09/30/ PY - 2010/05/05/received PY - 2010/08/17/accepted PY - 2010/10/19/entrez PY - 2010/10/19/pubmed PY - 2010/10/19/medline JF - Journal of obesity JO - J Obes VL - 2011 N2 - Obesity is a multifactorial condition resulting from improper balances of hormones and gene expression induced by the diet. Obesity also has a strong inflammatory component that can be driven by diet-induced increases in arachidonic acid. The purpose of this paper is to discuss the molecular targets that can be addressed by anti-inflammatory nutrition. These molecular targets range from reduction of proinflammatory eicosanoids to the modulation of features of the innate immune system, such as toll-like receptors and gene transcription factors. From knowledge of the impact of these dietary nutrients on these various molecular targets, it becomes possible to develop a general outline of an anti-inflammatory diet that can offer a unique synergism with more traditional pharmacological approaches in treating obesity and its associated comorbidities. SN - 2090-0716 UR - https://www.unboundmedicine.com/medline/citation/20953366/full_citation L2 - https://dx.doi.org/10.1155/2011/431985 DB - PRIME DP - Unbound Medicine ER -